切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2011, Vol. 05 ›› Issue (03) : 344 -349. doi: 10.3877/cma.j.issn.1674-0807.2011.03.011

综述

PIK3CA基因突变与乳腺癌的关系
李鑫1, 张瑾1,()   
  1. 1.300060 天津,乳腺癌防治教育部重点实验室,天津市“肿瘤防治”重点实验室,天津医科大学附属肿瘤医院
  • 收稿日期:2009-11-06 出版日期:2011-06-01
  • 通信作者: 张瑾

Relationship of PIK3CA gene mutation to breast cancer

Xin LI, Jin Zhang()   

  • Received:2009-11-06 Published:2011-06-01
  • Corresponding author: Jin Zhang
引用本文:

李鑫, 张瑾. PIK3CA基因突变与乳腺癌的关系[J/OL]. 中华乳腺病杂志(电子版), 2011, 05(03): 344-349.

Xin LI, Jin Zhang. Relationship of PIK3CA gene mutation to breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2011, 05(03): 344-349.

[1]
Anderson WF, Jatoi I, Devesa SS. Distinct breast cancer incidence and prognostic patterns in NCI's SEER program:suggesting a possible link between etiology and outcome [J]. Breast Cancer Res Treat, 2005,90(2):127-137.
[2]
Bader AG, Kang S, Zhao L, et al. Oncogenic PI3K deregulates transcription and translation [J]. Nature Rev,2005,5(12):921-929.
[3]
Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism[J]. Nature Rev, 2006,7(8);606-619.
[4]
Sun H, Lesche R, Li DM, et al. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol-3,4,5-trisphosphate and Akt/protein kinase B signaling pathway [J]. Proc Natl Acad Sci USA,1999,96(11):6199-6204.
[5]
Kang S, Bader AG, Vogt PK. Phosphatidylinositol 3 - kinase mutations identified in human cancer are oncogenic [J].Proc Natl Acad Sci USA, 2005,102(3):802-807.
[6]
Isakoff SJ, Engelman JA, Irie HY, et al. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells [J]. Cancer Res,2005,65(23):10992-11000.
[7]
Zhao JJ, Liu Z, Wang L, et al. The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells [J]. Proc Natl Acad Sci USA,2005,102(51):18443-18448.
[8]
Alex T, Merav YL. Akt signaling and cancer: surviving but not moving on. Cancer Res, 2006,66(8):3963-3966.
[9]
Samuels Y, Diaz LA Jr , Schmidt-kittler O, et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells[J]. Cancer Cell ,2005,7(6):561-573.
[10]
Guo XN, RajPut A, Rose R, et al. Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model [J]. Cancer Res,2007,67(12):5851-5858.
[11]
Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers [J]. Science,2004,304(5670):554-554.
[12]
Bachman KE, Argani P, Samuels Y, et al. The PIK3CA gene is mutated with high frequency in human breast cancers [J].Cancer Biol Ther,2004,3(8):772-775.
[13]
Saal LH, Holm K, Maurer M, et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma [J]. Cancer Res 2005,65(7):2554-2559.
[14]
Campbell IG, Russell SE, Choong DY, et al. Mutation of the PIK3CA gene in ovarian and breast cancer [J]. Cancer Res,2004,64(21):7678-7681.
[15]
Buttitta F, Felicioni L, Barassi F, et al. PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma [J]. J Pathol ,2006,208(3):350-355.
[16]
Li SY, Rong M, Grieu F, Iacopetta B. PIK3CA mutations in breast cancer are associated with poor outcome [J]. Breast Cancer Res Treat, 2006;96(1):91-95.
[17]
Maruyama N, Miyoshi Y, Taguchi T, et al. Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women [J]. Clin Cancer Res,2007,13(2 Pt 1):408-414.
[18]
Gustin JP, Cosgrove DP, Park BH. The PIK3CA gene as a mutated target for cancer therapy [J]. Curr Cancer Drug Targets,2008,8(8):733-740.
[19]
Bader AG, Kang S, Zhao L, et al. Oncogenic PI3K deregulates transcription and translation [J]. Nat Rev Cancer, 2005,5(12):921-929.
[20]
Bozhanov SS, Angelova SG, Krasteva ME, et al. Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer [J]. J Cancer Res Clin Oncol,2010,136 (11):1657-1669.
[21]
Martin MB, Franke TF, Stoica GE, et al. A role for AKT inmediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I [J]. Endocrinology ,2000,141(12):4503-4511.
[22]
Perez Tenorio G, Alkhori L, Olsson B, et al. PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer [J]. Clin Cancer Res ,2007,13(12):3577-3584.
[23]
Park BH, Davidson NE. PI3Kinase activation and response to trastuzumab therapy: what's neu with herceptin resistance[J]. Cancer Cell,2007 ,12(4):297-299.
[24]
Berns K, Horlings HM, Hennessy BT, et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer [J]. Cancer Cell,2007,12(4):395-402.
[25]
Kataoka Y, Mukohara T, Shimada H, et al. Association between gain-of-function mutations in PIK3CA and resistance to HER2-targeted agents in HER2-amplified breast cancer cell lines [J]. Ann Oncol,2010,21(2):255-262.
[26]
Barbareschi M, Buttitta F, Felicioni L, et al. Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas [J]. Clin Cancer Res,2007,13(20):6064-6069.
[27]
Liedtke C, Cardone L, Tordai A, et al. PIK3CA-activating mutations and chemotherapy sensitivity in stage II-III breast cancer [J]. Breast Cancer Res,2008,10(2):R27.
[28]
Kalinsky K, Jacks LM, Heguy A, et al. PIK3CA mutation associates with improved outcome in breast cancer [J]. Clin Cancer Res, 2009,15(16):5049-5059.
[29]
Aleskandarany MA, Rakha EA, Ahmed MA, et al. PIK3CA expression in invasive breast cancer: a biomarker of poor prognosis [J]. Breast Cancer Res Treat,2010,122(1):45-53.
[30]
Di Cosimo S, Baselga J. Phosphoinositide 3-kinase mutations in breast cancer: a ‘‘good’’ activating mutation? [J]. Clin Cancer Res,2009,15(16):5017-5019.
[31]
Lerma E, Catasus L, Gallardo A, et al. Exon 20 PIK3CA mutations decreases survival in aggressive (HER-2 positive)breast carcinomas [J]. Virchows Arch,2008,453(2):133-139.
[32]
Ellis MJ, Lin L, Crowder R, et al. Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer [J]. Breast Cancer Res Treat ,2010,119 (2):379-390.
[33]
Benvenuti S, Frattini M, Arena S, et al. PIK3CA cancer mutations display gender and tissue specificity patterns [J]. Hum Mutat,2008,29(2):284-288
[34]
Lai YL, Mau BL, Cheng WH, et al. PIK3CA exon 20 mutation is independently associated with a poor prognosis in breast cancer patients [J]. Ann Surg Oncol,2008,15(4):1064-1069.
[35]
Dressman D, Yan H, Traverso G, et al. Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations [J]. Proc Natl Acad Sci USA ,2003,100(15): 8817-8822.
[36]
Diehl F, Li M, Dressman D, et al. Detection and quantification of mutations in the plasma of patients with colorectal tumors[J]. Proc Natl Acad Sci USA,2005, 102(45): 16368-16373.
[37]
Crowder RJ, Phommaly C, Tao Y, et al . PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer [J]. Cancer Res,2009,69(9):3955 - 3962.
[1] 李洋, 蔡金玉, 党晓智, 常婉英, 巨艳, 高毅, 宋宏萍. 基于深度学习的乳腺超声应变弹性图像生成模型的应用研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 563-570.
[2] 河北省抗癌协会乳腺癌专业委员会护理协作组. 乳腺癌中心静脉通路护理管理专家共识[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 321-329.
[3] 刘晨鹭, 刘洁, 张帆, 严彩英, 陈倩, 陈双庆. 增强MRI 影像组学特征生境分析在预测乳腺癌HER-2 表达状态中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 339-345.
[4] 张晓宇, 殷雨来, 张银旭. 阿帕替尼联合新辅助化疗对三阴性乳腺癌的疗效及预后分析[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 346-352.
[5] 邱琳, 刘锦辉, 组木热提·吐尔洪, 马悦心, 冷晓玲. 超声影像组学对致密型乳腺背景中非肿块型乳腺癌的诊断价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 353-360.
[6] 程燕妮, 樊菁, 肖瑶, 舒瑞, 明昊, 党晓智, 宋宏萍. 乳腺组织定位标记夹的应用与进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 361-365.
[7] 涂盛楠, 胡芬, 张娟, 蔡海峰, 杨俊泉. 天然植物提取物在乳腺癌治疗中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 366-370.
[8] 朱文婷, 顾鹏, 孙星. 非酒精性脂肪性肝病对乳腺癌发生发展及治疗的影响[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 371-375.
[9] 周荷妹, 金杰, 叶建东, 夏之一, 王进进, 丁宁. 罕见成人肋骨郎格汉斯细胞组织细胞增生症被误诊为乳腺癌术后骨转移一例[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 380-383.
[10] 韩萌萌, 冯雪园, 马宁. 乳腺癌改良根治术后桡神经损伤1例[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 117-118.
[11] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[12] 张志兆, 王睿, 郜苹苹, 王成方, 王成, 齐晓伟. DNMT3B与乳腺癌预后的关系及其生物学机制[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 624-629.
[13] 王玲艳, 高春晖, 冯雪园, 崔鑫淼, 刘欢, 赵文明, 张金库. 循环肿瘤细胞在乳腺癌新辅助及术后辅助治疗中的应用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 630-633.
[14] 赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
[15] 刘文竹, 唐窈, 刘付臣. 诱导多潜能干细胞在神经肌肉疾病研究中的应用进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 367-373.
阅读次数
全文


摘要