切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2011, Vol. 05 ›› Issue (01) : 48 -51. doi: 10.3877/cma.j.issn.1674-0807.2011.01.015

综述

表皮生长因子受体Ⅲ型突变体靶向治疗乳腺肿瘤的研究进展
李雨弥1, 徐卫云2,()   
  1. 1.646000 四川泸州,泸州医学院附属医院普外科
    2.621000,四川绵阳,绵阳市中心医院乳腺外科
  • 收稿日期:2009-11-22 出版日期:2011-02-01
  • 通信作者: 徐卫云

Progresses in study of epidermal growth factor receptor Ⅲ targeted therapy of breast tumors

Yu-mi LI, Wei-yun XU()   

  • Received:2009-11-22 Published:2011-02-01
  • Corresponding author: Wei-yun XU
引用本文:

李雨弥, 徐卫云. 表皮生长因子受体Ⅲ型突变体靶向治疗乳腺肿瘤的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2011, 05(01): 48-51.

Yu-mi LI, Wei-yun XU. Progresses in study of epidermal growth factor receptor Ⅲ targeted therapy of breast tumors[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2011, 05(01): 48-51.

[1]
Silva HA,Raimundo D,Dias MF,et al.Molecular detection of EGFRvⅢ-positive cells in the peripheral blood of breast cancer patients[J].Eur J Cancer,2006,42(15):2617-2622.
[2]
Yu H,Gong X,Luo X,et al.Co-expression of EGFRvⅢ with ErbB-2 enhances tumorigenesis:EGFRvⅢ mediated constitutively activated and sustained signaling pathways,whereas EGF-induced a transient effect on EGFR-mediated signaling pathways[J].Cancer Biol Ther,2008,7(11):1818-1829.
[3]
Friedman HS,Bigner DD.Glioblastoma multiforme and the epidermal growth factor receptor[J].N End J Med,2005,353(19):1997-1999.
[4]
Patel D,Lahiji A,Patel S,et al.Monoclonal antibody cetuximab binds to and down-regulates constitutively activated epidermal growth factor receptor vⅢ on the cell surface[J].Anticancer Res,2007,27(5):3355-3366.
[5]
Li G,Wong AJ.EGF receptor variant Ⅲ as a target antigen for tumor immunotherapy[J].Expert Rev Vaccines,2008,7(7):977-985.
[6]
Stutz MA,Shattuck DL,Laederich MB,et al.LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRv Ⅲ[J].Oncogene,2008,27(43):5741-5752.
[7]
Li B,Yuan M,Kim IA,et al.Mutant epidermal growth factor receptor displays increased signaling through the phospha-tidylinostol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin[J].Oncogene,2004,23(26):4594-4602.
[8]
Theys J,Jutten B,Dubois L,et al.The deletion mutant EGFRvⅢsignificantly contributes to stress resistance typical for the tumor microenvironment[J].Radiother Oncol,2009,92(3):399-404.
[9]
Zhang Y,Su H,Rahimi M,et al.EGFRv Ⅲ-induced estrogenindependence,tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer[J].Int J Cancer,2009,125(9):2021-2028.
[10]
Luo X,Gong X,Tang K.Suppression of EGFRv Ⅲ-mediated proliferation and tumor genesis of breast cancer cells by ribozyme[J].Int J Cancer,2003,104(6):716-721.
[11]
Allen LF,Lenehan PF,Eiseman IA,et al.Potential benefits of the irreversible pan-erbB inhibitor,CI-1033,in the treatment of breast cancer[J].Seminars in oncology,2002,29(3):11-21.
[12]
Han W,Zhang T,Yu H,et al.Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvⅢ[J].Cancer biol ther,2006,5(10):1361-1368.
[13]
Gong J,Nikrui N,Chen D,et al.Fusions of human ovarian carcinoma cells with autologous or allogeneic dendritic cells induce antitumor immunity[J].Immunology,2000,165(3):1705-1711.
[14]
Wu AH,Xiao J,Anker L,et al.Identification of EGFRvⅢ-derived CTL epitopes restricted by HLA A0201 for dendritic cell based immunotherapy of gliomas[J].J Neurooncol,2006,76(1):23-30.
[15]
Heimberger AB,Crotty LE,Archer GE,et al.Epidermal growth factor receptor V Ⅲ peptide vaccination is efficacious against established intracerebral tumors[J].Clin Cancer Res,2003,9(11):4247-4254.
[16]
Schmittling RJ,Archer GE,Mitchell DA,et al.Detection of humoral response in patients with glioblastoma receiving EGFRvⅢ-KLH vaccines[J].J Immunol Methods,2008,339(1):74-81.
[17]
Wikstrand CJ,Cole VR,Crotty LE,et al.Generation of antiidiotypic reagents in the EGFRv Ⅲtumor-associated antigen system[J].Cancer Immunol Immunother,2002,50(12):639-652.
[18]
Wang X,Ko EC,Peng L,et al.Human high molecular weight melanoma-associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23:enhancement of immunogenicity of anti-idiotypic monoclonal antibody MK2-23 by fusion with interleukin 2[J].Cancer Res,2005,65(15):6976-6983.
[19]
Modjtahedi H,Moscatello DK,Box G,et al.Targeting of cells expressing wild-type EGFR and type-Ⅲ mutant EGFR(EGFRvⅢ)by anti-EGFR MAb ICR62:a two-pronged attack for tumor therapy[J].IntJ Cancer,2003,105(2):273-280.
[20]
Modjtahedi H,Moscatello DK,Box G,et al.Targeting of cells expressing wild-type EGFR and type-Ⅲmutant EGFR(EGFRvⅢ)by anti-EGFR MAb ICR62:a two-pronged attack for tumor therapy[J].Int J Cancer,2003,105(2):273-280.
[21]
Perera RM,Narita Y,Furnari FB,et al.Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity[J].Clin Cancer Res,2005,11(17):6390-6399.
[22]
Patel D,Lahiji A,Patel S,et al.Monoclonal antibody cetuximab binds to and down-regulates constitutively activated epidermal growth factor receptor vⅢ on the cell surface[J].Anticancer Res,2007,27(5):3355-3366.
[23]
Denholt CL,Hansen PR,Pedersen N,et al.Identification of novel peptide ligands for the cancer-specific receptor mutation EGFRvⅢusing a mixture-based synthetic combinatorial library[J].Biopolymers,2009,91(3):201-206.
[24]
Balyasnikova Ⅳ,Franco Gou R,Mathis JM,et al.Genetic modification of mesenchymal stem cells to express a single-chain antibody against EGFRvⅢ on the cell surface[J].J Tissue Eng Regen Med,2010,4(4):247-258.
[25]
Scott AM,Lee FT,Tebbutt N,et al.A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors[J].Proc NatlAcad Sci USA,2007,104(10):4071-4076.
[26]
Fury MG,Lipton A,Smith KM,et al.A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocytecolony stimulating factor in patients with advanced solid tumors[J].Cancer Immunol Immunother,2008,57(2):155-163.
[27]
Ou C,Wu FX,Luo Y,et al.Expression and significance of epidermal growth factor receptor variant type Ⅲ in hepatocellular carcinoma[J].Ai Zheng,2005,24(2):166-169.
[28]
Bonner JA,Harari PM,Giralt J,et al.Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck[J].N EnglJ Med,2006,354(6):567-578.
[29]
Van Cutsem E,Peeters M,Siena S,et al.Open-label phase Ⅲ trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer[J].J Clin Oncol,2007,25(13):1658-1664.
[30]
Food KA,Yang XD,Weiner LM,et al.Preclinical and clinical evaluations of ABX-EGF,a fully human anti-epidermal growth factor receptor antibody[J].Int J Radiat Oncol Biol Phys,2004,58(3):984-990.
[31]
RochaLima CM,Soares HP,Raez LE,et al.EGFR targeting of solid tumors[J].Cancer Control,2007,14(3):295-304.
[32]
Overman MJ,Hoff PM.EGFR-targeting therapies in colorectal cancer[J].Dis Colon Rectum,2007,50(8):1259-1270.
[33]
Gupta P,Han SY,Hoqado Madruqa M,et al.Development of an EGFRvⅢ specific recombinant antibody[J].BMC Biotecthnol,2010,10:72.
[1] 李洋, 蔡金玉, 党晓智, 常婉英, 巨艳, 高毅, 宋宏萍. 基于深度学习的乳腺超声应变弹性图像生成模型的应用研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 563-570.
[2] 河北省抗癌协会乳腺癌专业委员会护理协作组. 乳腺癌中心静脉通路护理管理专家共识[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 321-329.
[3] 刘晨鹭, 刘洁, 张帆, 严彩英, 陈倩, 陈双庆. 增强MRI 影像组学特征生境分析在预测乳腺癌HER-2 表达状态中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 339-345.
[4] 张晓宇, 殷雨来, 张银旭. 阿帕替尼联合新辅助化疗对三阴性乳腺癌的疗效及预后分析[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 346-352.
[5] 邱琳, 刘锦辉, 组木热提·吐尔洪, 马悦心, 冷晓玲. 超声影像组学对致密型乳腺背景中非肿块型乳腺癌的诊断价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 353-360.
[6] 程燕妮, 樊菁, 肖瑶, 舒瑞, 明昊, 党晓智, 宋宏萍. 乳腺组织定位标记夹的应用与进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 361-365.
[7] 涂盛楠, 胡芬, 张娟, 蔡海峰, 杨俊泉. 天然植物提取物在乳腺癌治疗中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 366-370.
[8] 朱文婷, 顾鹏, 孙星. 非酒精性脂肪性肝病对乳腺癌发生发展及治疗的影响[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 371-375.
[9] 周荷妹, 金杰, 叶建东, 夏之一, 王进进, 丁宁. 罕见成人肋骨郎格汉斯细胞组织细胞增生症被误诊为乳腺癌术后骨转移一例[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 380-383.
[10] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[11] 韩萌萌, 冯雪园, 马宁. 乳腺癌改良根治术后桡神经损伤1例[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 117-118.
[12] 张志兆, 王睿, 郜苹苹, 王成方, 王成, 齐晓伟. DNMT3B与乳腺癌预后的关系及其生物学机制[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 624-629.
[13] 王玲艳, 高春晖, 冯雪园, 崔鑫淼, 刘欢, 赵文明, 张金库. 循环肿瘤细胞在乳腺癌新辅助及术后辅助治疗中的应用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 630-633.
[14] 刘先勇, 秦东梅, 张若梅, 李俊娇, 孟春芹, 邬明歆, 王玉红, 赵新鲜, 徐瑞联, 洪文文, 马玲, 仇玮, 周宇. Her2/Hes1在肠型胃癌Correa级联反应3个病理阶段中的表达及意义[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 321-327.
[15] 陈伟杰, 何小东. 胆囊癌免疫靶向治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 763-768.
阅读次数
全文


摘要