目的

探讨三阴性乳腺癌的临床病理特点。

方法

对2004 年6 月至2007 年12 月间本院收治的35 例三阴性(TN)乳腺癌患者的临床资料包括发病年龄、月经状态、临床表现、病理类型、组织学分级、淋巴结转移情况、P53 表达及病死率进行回顾性分析,并与同期非三阴性(NTN)乳腺癌进行比较。

结果

与NTN 组相比,TN 组的患者中位年龄较NTN 组年轻(35 岁比44 岁,P =0.010)且绝经前患者较多(88.5%比67.3%,P =0.010);TN 组浸润性导管癌较NTN组多见(91.4%比70.2%,P =0.008),且组织学分级Ⅲ级者较多(43.8%比22.5%, P =0.000);TN 组淋巴结转移阳性者较NTN 组少(31.8%比64.4%,P =0.000);TN 组P53 阳性表达率高于NTN 组(51.4%比20.7%,P =0.000)。 中位随访24 个月,两组死亡率差别无统计学意义(P =0.377)。

结论

三阴性乳腺癌多见于年轻的绝经前妇女,主要病理类型为非特殊类型的高分级浸润性导管癌,淋巴结转移少见,P53 阳性表达率较高。

Objective

To explore the clinical and pathological characteristics of triple-negative breast cancer.

Method

The data of 35 patients with triple-negative breast cancer (TN) including age, the state of menstruation, symptom, pathological type,histological grade,metastasis of lymph node,the expression of P53 and follow-up were analyzed retrospectively and compared with those of non triple-negative breast cancer (NTN) patients.

Results

The patients with TN were younger than those with NTN(35 vs 44,P=0.010), and most of the patients with TN were premenopausal at diagnosis(88.5% vs 67.3%,P=0.010). The frequency of invasive ductal carcinoma was higher in patients with TN than with NTN (91.4% vs 70.2%, P=0.008. Generally patients with TN had higher grade tumors (grade Ⅲ)than patients with NTN (43.8% vs 22.5%, P=0.000). Lower rate of lymph node metastasis and higher rate of positive expression of P53 were observed in patients with TN than with NTN(31.8% vs 64.4%, P=0.000 and 51.4% vs 20.7%, P =0.000). Median follow-up time was 24 months. There was no difference in mortality between the two groups (P=0.377).

Conclusions

Triple-negative breast cancer is common in young premenopausal Chinese women. Its main pathological style is non-special type of invasive ductal carcinoma with high grade, with low rate lymph node metastasis and high rate of positive expression of P53 and poor outcome. The short time of follow-up in our series showed no increased mortahty.