目的

探讨聚集素（clusterin）、Bax在乳腺浸润性导管癌中的表达及意义。

方法

采用S-P免疫组化方法，检测乳腺浸润性导管癌组织中clusterin和Bax的表达状态。

结果

Clusterin在正常乳腺组织中不表达，在62.79%（27/43）的乳腺浸润性导管癌组织中阳性表达。Clusterin在乳腺浸润性导管癌组织中的表达与年龄、绝经状态无关，而与肿瘤的分化程度（r=0.3799，P=0.0266）、临床分期（r=0.3206，P=0.0356）、肿瘤大小（r=0.3671，P=0.0365）及有无淋巴结转移（r=0.5937，P=0.0005）呈正相关。Clusterin与Bax的表达呈负相关（r=-0.3273，P﹤0.05），与ER、PR的表达状态均呈负相关（r分别为-0.3038、-0.3451，P分别为0.0125、0.0236），与HER-2表达无相关性（r=0.2644，P=0.1719）。

结论

Clusterin的表达状态在乳腺癌的发生、发展中可能起着重要的作用。

Objective

To investigate the expression and significance of clusterin（a newly discovered antipoptosis protein，which is overexpressed in many cancers and plays an important role in the development of cancer）in infiltrating ductal carcinoma of the breast.

Methods

The expressions of clusterin and Bax in infiltrating ductal carcinoma of the breast were examined by immunohistochemical S-P method.

Results

The expression of clusterin was negative in normal breast tissues.The overexpression rate of clusterin in infiltrating ductal carcinoma of the breast was 62.79%（27/43）.The expression level of clusterin in infiltrating ductal carcinoma of the breast was not related to age and mentopausal state，but was related positively with pathological differentiation（r=0.3799，P=0.0266），clinical stage（r=0.3206，P=0.0356）and lymph node metastasis（r=0.5937，P=0.0005）.The expression level of clusterin in infitrating ductal carcinoma of the breast had a negative correlation with Bax（r=-0.3273，P﹤0.05），ER（r=-0.3038，P﹤0.05）and PR expression（r=-0.3451，P﹤0.05），and had no correlation with HER-2（r=0.2644，P﹥0.05）.

Conclusion

Clusterin may play an important role in the carcinogenesis and development of infiltrating breast carcinoma.