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中华乳腺病杂志(电子版) ›› 2015, Vol. 09 ›› Issue (01) : 50 -53. doi: 10.3877/cma. j. issn.1674-0807.2015.01.011

综述

增殖细胞核抗原Ki67 与乳腺癌新辅助化疗疗效的关系
桑蝶1, 王佳玉1, 徐兵河1,()   
  1. 1.100021 中国医学科学院北京协和医学院肿瘤医院内科
  • 收稿日期:2014-04-22 出版日期:2015-02-01
  • 通信作者: 徐兵河

Correlation between Ki67 and efficacy of neoadjuvant chemotherapy in breast cancer

Die Sang, Jiayu Wang, Binghe Xu()   

  • Received:2014-04-22 Published:2015-02-01
  • Corresponding author: Binghe Xu
引用本文:

桑蝶, 王佳玉, 徐兵河. 增殖细胞核抗原Ki67 与乳腺癌新辅助化疗疗效的关系[J/OL]. 中华乳腺病杂志(电子版), 2015, 09(01): 50-53.

Die Sang, Jiayu Wang, Binghe Xu. Correlation between Ki67 and efficacy of neoadjuvant chemotherapy in breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2015, 09(01): 50-53.

表1 有关增殖细胞核抗原Ki67 的主要研究
[1]
Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CA Cance J Clin,2011,61(2): 69-90.
[2]
郑莹,吴春晓,吴凡. 中国女性乳腺癌死亡现状和发展趋势[J].中华预防医学杂志,2011,45(2): 150-154.
[3]
Yerushalmi R,Woods R,Ravdin PM,et al. Ki67 in breast cancer: prognostic and predictive potential[J]. Lancet Oncol,2010,11(2): 174-183.
[4]
Gerdes J,Schwab U,Lemke H,et al. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation [J]. Int J Cancer,1983,31(1): 13-20.
[5]
Gerdes J,Lemke H,Baisch H,et al.Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki67[J]. J Immunol,1984,133 (4): 1710-1715.
[6]
MacCallum DE,Hall PA. The location of pKi67 in the outer dense fibrillary compartment of the nucleolus points to a role in ribosome biogenesis during the cell division cycle[J].J Pathol,2000,190(5): 537-544.
[7]
Cheang MC,Chia SK,Voduc D,et al. Ki67 index,HER2 status,and prognosis of patients with luminal B breast cancer[J].J Natl Cancer Inst,2009,101(10): 736-750.
[8]
曹丹霞,何建蓉,沈坤炜,等.激素受体和HER-2 及Ki-67 预测乳腺癌新辅助化疗疗效价值的分析[J].中华肿瘤防治杂志,2012,19(13): 1000-1003.
[9]
Bear HD,Anderson S,Brown A,et al. The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27[J]. J Clin Oncol,2003,21(22): 4165-4174.
[10]
黄朝光,辛付莹.乳腺癌P53、Ki-67 表达与新辅助化疗疗效的相关性研究[J]. 中国社区医师(医学专业),2011,13(271): 260.
[11]
黄宇,胡晓桦,刘志辉.Ki-67 表达与鼻咽癌、乳腺癌化疗疗效及预后的临床分析[J/CD].中华临床医师杂志: 电子版,2013,7(2): 641-645.
[12]
张云好,陈天文,王开昕,等.Ki67 表达在乳腺癌新辅助化疗中的临床意义[J].实用医院临床杂志2012,9(4): 60-62.
[13]
Nishimura R,Osako,Okumura Y,et al. Clinical significance of Ki67 in neoadjuvant chemotherapy for primary breast cancer as a predictor for chemosensitivity and for prognosis [J]. Breast Cancer,2010,17 (4): 269-275.
[14]
Goldhirsch A, Wood WC, Coates AS, et al. Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St.gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011 [J]. Ann Oncol,2011,22(8): 1736-1747.
[15]
de Azambuja E,Cardoso F,de Castro G Jr,et al. Ki67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12 155 patients [J]. Br J Cancer,2007,96(10): 1504-1513.
[16]
Von minckwitz G,Schmitt WD,Loibl S,et al. Ki67 measured after neoadjuvant chemotherapy for primary breast cancer [J].Clin Cancer Res,2013,19(16): 4521-4531.
[17]
Ohno S, Chow LW, Sato N, et al. Randomized trial of preoperative docetaxel with or without capecitabine after 4 cycles of 5-fluorouracil-epirubicin-cyclophosphamide(FEC) in early-stage breast cancer: exploratory analyses identify Ki67 as a predictive biomarker for response to neoadjuvant chemotherapy[J].Breast Cancer Res Treat,2013,142(1): 69-80.
[18]
Yoshioka T, Hosoda M, Yamamoto M, et al. Prognostic significance of pathologic complete response and Ki67 expression after neoadjuvant chemotherapy in breast cancer[J].Breast Cancer,2015,22(2): 185-191.
[19]
程岩,徐玲,刘倩,等.乳腺癌新辅助治疗疗效相关因素分析[J].中国实用外科杂志,2012,32(11): 950-952.
[20]
Denkert C,Loibl S,Müller BM,et al. Ki67 levels as predictive and prognostic parameters in pretherapeutic breast cancer core biopsies: a translational investigation in the neoadjuvant GeparTrio trial[J].Ann Oncol,2013,24(11): 2786-2793.
[21]
Sueta A,Yamamoto Y,Hayashi M,et al.Clinical significance of pretherapeutic Ki67 as a predictive parameter for response to neoadjuvant chemotherapy in breast cancer: is it equally useful across tumor subtypes? [J].Surgery,2014,155(5): 927-935.
[22]
马祥君,何湘萍,汪洁,等. 乳腺癌新辅助化疗后不同时间Ki-67 变化规律研究[J]. 中华肿瘤防治杂志,2010,17(13): 976-978.
[23]
Citron ML,Berry DA,Cirrincione C,et al. Randomized trial of dose-dense versus Conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trail 9741[J].J Clin Oncol,2003,21(8): 1431-1439.
[24]
Dent R,Trudeau M,Pritchard KI,et al. Triple-negative breast cancer: clinical features and patterns of recurrence[J]. Clin Cancer Res,2007,13(15 pt 1): 4429-4434.
[25]
Liedtke C,Mazouni C,Hess KR,et al.Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer [J].J Clin Oncol,2008,26(8): 1275-1281.
[26]
Colleoni M,Viale G,Zahrieh D,et al. Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment[J]. Clin Cancer Res,2004,10(19): 6622-6628.
[27]
Silver DP, Richardson AL, Eklund AC, et al. Efficacy of neoadjuvant cisplatin in triple-negative breast cancer [J]. J Clin Oncol,2010,28(7): 1145-1153.
[28]
叶国麟,杨劼,古卫权,等.Ki-67 表达对“三阴性”乳腺癌新辅助化疗疗效影响[J].河北医学,2013,19(6): 832-834.
[29]
戴文斌,黄平,任占平,等. MCM7 和Ki-67 在乳腺癌中的表达及其与新辅助化疗关系的研究[J].实用肿瘤杂志,2010,25(1): 20-23.
[30]
朱伟良,谈炎,王旭芬,等. Ki-67 在乳腺癌各亚型中的表达及意义[J].中国癌症杂志,2012,22(5): 347-351.
[31]
王永南,王颀,张安泰,等. Ki-67 与分子亚型预测乳腺癌新辅助化疗敏感性的研究[J]. 中华肿瘤防治杂志,2012,19(23): 1805-1809.
[32]
von Minckwitz G,Sinn HP,Raab G,et al.Clinical response after two cycles compared to HER2, Ki-67, p53, and bcl-2 in independently predicting a pathological complete response after preoperative chemotherapy in patients with operable carcinoma of the breast [J].Breast Cancer Res,2008,10(2): R30.
[33]
Wang J,Xu B,Yuan P,et al. TOP2A amplification in breast cancer is a predictive marker of anthracycline-based neoadjuvant chemotherapy efficacy [J]. Breast Cancer Res Treat,2012,135(2): 531-537.
[34]
Jones RL,Salter J,A’Hern R,et al.The prognostic significance of Ki67 before and after neoadjuvant chemotherapy in breast cancer[J].Breast Cancer Res Treat,2009,116(1): 53-68.
[35]
Jacquemier J,Charafe-Jauffret E,Monville F,et al. Association of GATA3,P53,Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer [J]. Breast Cancer Res,2009,11(2): R23.
[36]
Ahlin C, Fernö M,Amini RM,et al. Ki67 and cyclin Aprognostic factors in breast cancer. Time to introduce proliferation markers in clinical routine [J]. Lakartidningen,2010,107(10): 672-675.
[37]
Werynska B,Pula B,Muszczynska-Bernhard B,et al.Correlation between expression of metallothionein and expression of Ki67 and MCM-2 proliferation markers in non-small cell lung cancer[J].Anticancer Res,2011,31(9): 2833-2839.
[38]
Sole CV, Calvo FA. Research opportunities for vascular endothelial growth factor receptor and Ki67 relative percentage co-reduction in patients with locally advanced rectal cancer treated with neoadjuvant therapy [J]. Clin Oncol, 2014,26(2): 122-123.
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