Effect of myofascial release in breast cancer patients after radical mastectomy： a randomized controlled study

doi:10.3877/cma.j.issn.1674-0807.2025.02.007

Abstract

Abstract:

Objective

To investigate the effects of myofascial release technique on shoulder joint function and quality of life in patients after radical mastectomy for breast cancer.

Methods

A prospective analysis was conducted on 82 breast cancer patients who underwent radical mastectomy in the Xindu District Hospital of Traditional Chinese Medicine， Chengdu， from October 2021 to February 2023. Patients were randomly divided into a control group and an observation group （41 cases each） using a random number table method. The control group received manual lymphatic drainage postoperatively， while the observation group received myofascial release therapy. Shoulder joint flexion， extension， internal rotation， and external rotation angles， as well as Visual Analogue Scale （VAS） scores， were measured before treatment， immediately after treatment， and one month after treatment. Repeated measures ANOVA was used for intergroup comparisons.The Patient Health Questionnaire-9 （PHQ-9）， Disabilities of the Arm， Shoulder and Hand （DASH） scale，and Functional Assessment of Cancer Therapy-Breast （FACT-B） scores were assessed before treatment， after treatment， and one month after treatment， with intergroup comparisons performed using t-tests.

Results

The observation group showed significantly lower VAS scores than the control group （between-group： F=17.869，P＜0.001； time effect： F=105.517，P＜0.001；interaction： F=32.303，P＜0.001）. Shoulder joint mobility（flexion， extension， internal rotation， and external rotation angles） was significantly better in the observation group （flexion： between-group： F=5.636， P=0.020； time effect： F=33.024， P＜0.001； interaction： F=7.635， P=0.007； extension angle： between-group： F=8.829， P=0.004； time effect： F=197.515， P＜0.001； interaction F=23.266， P＜0.001； internal rotation angle： between-group： F=5.409， P=0.023； time effect： F=73.649， P＜0.001； interaction effect： F=24.294， P＜0.001； external rotation angle： betweengroup： F=7.970， P=0.006； time effect： F=84.163，P＜0.001； interaction： F=14.369，P＜0.001）. The scores of the PHQ-9 and the DASH in the observation group were significantly lower than those in the control group （t=5.937，P＜ 0.001；t=3.034，P=0.003）， and the score of the FACT-B scale was significantly higher than that of the control group （t=3.166，P=0.002）.

Conclusion

Myofascial release therapy improves overall shoulder mobility， reduces pain and depressive symptoms， and enhances quality of life in post-mastectomy patients， demonstrating promising clinical efficacy and application potential.

Key words: Myofascial release, Radical mastectomy for breast cancer, Quality of life

Jian Zhang, Xiaojun Chen, Jian Yang, Xinjie Chen. Effect of myofascial release in breast cancer patients after radical mastectomy： a randomized controlled study[J]. Chinese Journal of Breast Disease(Electronic Edition), 2025, 19(02): 103-107.

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URL: https://zhrxbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0807.2025.02.007

https://zhrxbzz.cma-cmc.com.cn/EN/Y2025/V19/I02/103

Figures/Tables 4

临床病理因素	对照组（41 例）	观察组（41 例）	检验值	P值
年龄（岁， $\overset{ˉ}{x}$ ± s ）	52. 4±10. 7	52. 7±10. 9	t=0. 113	0. 910
肿瘤直径（cm， $\overset{ˉ}{x}$ ± s ）	1. 0±0. 4	0. 92±0. 43	t=0. 545	0. 587
肿瘤部位［例（%）］
左侧乳房	17（41. 5）	15（36. 6）	χ ²=0. 205	0. 651
右侧乳房	24（58. 5）	26（63. 4）
TNM 分期［例（%）］
Ⅰ期	18（43. 9）	17（41. 5）	χ ²=0. 050	0. 823
Ⅱ期	23（56. 1）	24（58. 5）

临床病理因素	对照组（41 例）	观察组（41 例）	检验值	P值
年龄（岁， $\overset{ˉ}{x}$ ± s ）	52. 4±10. 7	52. 7±10. 9	t=0. 113	0. 910
肿瘤直径（cm， $\overset{ˉ}{x}$ ± s ）	1. 0±0. 4	0. 92±0. 43	t=0. 545	0. 587
肿瘤部位［例（%）］
左侧乳房	17（41. 5）	15（36. 6）	χ ²=0. 205	0. 651
右侧乳房	24（58. 5）	26（63. 4）
TNM 分期［例（%）］
Ⅰ期	18（43. 9）	17（41. 5）	χ ²=0. 050	0. 823
Ⅱ期	23（56. 1）	24（58. 5）

组别	例数	VAS 评分
组别	例数	治疗前	治疗结束时	治疗后1 个月
对照组	41	5. 9±2. 3	4. 7±1. 9^a	4. 9±2. 2^a
观察组	41	6. 0±2. 5	2. 8±1. 5^a	2. 3±1. 1^a
t 值		0. 188	5. 026	6. 768
P值		0. 851	＜0. 001	＜0. 001

组别	例数	屈曲角度			伸展角度			内旋角度			外旋角度
组别	例数	治疗前	治疗结束时	治疗后1 个月	治疗前	治疗结束时	治疗后1 个月	治疗前	治疗结束时	治疗后1 个月	治疗前	治疗结束时	治疗后1 个月
对照组	41	153. 9±14. 0	156. 1±15. 9	158. 2±14. 7^a	35. 0±10. 0	40. 4±9. 0^a	45. 2±9. 6^a	70. 5±10. 7	74. 4±7. 1^a	73. 8±8. 9^a	61. 0±10. 5	63. 1±10. 7	66. 3±6. 1^a
观察组	41	155. 2±13. 9	165. 0±12. 1^a	167. 4±15. 0^a	34. 3±11. 2	47. 1±10. 3^a	55. 3±9. 7^a	69. 9±11. 1	78. 5±6. 6^a	85. 2±9. 4^a	60. 3±9. 9	71. 2±8. 8^a	73. 1±7. 6^a
t 值		0. 437	2. 865	2. 852	0. 299	3. 136	4. 739	0. 261	2. 708	5. 639	0. 311	3. 744	4. 468
P值		0. 663	0. 005	0. 006	0. 766	0. 002	＜0. 001	0. 795	0. 008	＜0. 001	0. 757	＜0. 001	＜0. 001

组别	例数	PHQ-9 评分		DASH 评分		FACT-B 评分
组别	例数	治疗前	治疗后1 个月	治疗前	治疗后1 个月	治疗前	治疗后1 个月
对照组	41	20. 8±4. 9	17. 4±4. 3^a	65. 3±13. 3	57. 7±15. 8^a	77. 5±15. 1	84. 2±13. 0^a
观察组	41	20. 7±4. 8	12. 2±3. 6^a	66. 0±14. 4	48. 3±12. 0^a	76. 0±14. 9	92. 4±10. 3^a
t 值		0. 093	5. 937	0. 229	3. 034	0. 453	3. 166
P值		0. 926	＜0. 001	0. 820	0. 003	0. 652	0. 002

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