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Chinese Journal of Breast Disease(Electronic Edition) ›› 2024, Vol. 18 ›› Issue (05): 257-263. doi: 10.3877/cma.j.issn.1674-0807.2024.05.001

• Forum of Specialists •     Next Articles

Application of multi-gene panel testing in adjuvant therapy for early breast cancer

Rui Ge1,(), Fei Chen2, Jie Li3, Juanjuan Li4, Han Chen5   

  1. 1.Department of General Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China
    2.Department of General Surgery, Putuo People’s Hospital Affiliated to Tongji University, Shanghai 200060, China
    3.Department of Breast and Thyroid Surgery,Guangzhou Women and Children’s Medical Center, Guangzhou 510623, China
    4.Breast and Thyroid Center,People’s Hospital of Wuhan University, Wuhan 430060, China
    5.Department of General Surgery,PLA Navy 905 Hospital, Shanghai 200052, China
  • Received:2024-09-24 Online:2024-10-01 Published:2024-11-14
  • Contact: Rui Ge

Abstract:

Multi-gene panel testing has provided new strategies and approaches for adjuvant therapy in early breast cancer. With continuous development and application of genomic technologies, multi-gene panel testing plays an increasingly important role in prognosis evaluation, efficacy prediction, and treatment decisionmaking in early breast cancer. Currently, multi-gene panel testing has shown a significant value in chemotherapy decision-making, extended endocrine therapy, and adjuvant radiotherapy decision-making for hormonal receptor positive and HER-2 negative (HR+/HER-2-) breast cancer, and potentials in neoadjuvant therapy for triple negative breast cancer. Some explorative studies are conducted in HER-2-positive breast cancer, but its value still needs further confirmation. This article reviewed the application of multi-gene panel testing tools clinically used in individualized adjuvant therapy for early breast cancer, providing a reference for clinical practice.

Key words: Multigene testing, Breast neoplasms, Adjuvant therapy, Prognosis

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