Abstract:
Objective To explore the expression levels of dual specific phosphatase 14 (DUSP14) and nuclear receptor interacting protein 1 (NRIP1) in triple negative breast cancer (TNBC) and their relationship with patients’ prognosis.
Methods A total of 106 TNBC patients admitted to Fenyang Hospital Affiliated to Shanxi Medical University from May 2018 to March 2020 were selected as the subjects for a retrospective study. Immunohistochemical methods were applied to detect the expression levels of DUSP14 and NRIP1 in TNBC tissues and adjacent normal tissues, and the paired chi-square test was used to analyze the difference. The correlation of DUSP14 and NRIP1 in TNBC tissues was analyzed by the Spearman analysis. The Kaplan-Meier survival analysis and log-rank test were applied to analyze the relationship between the expression of DUSP14 and NRIP1 in TNBC tissues and patients’ prognosis. The COX analysis was applied to find the prognostic factors of TNBC patients.
Results The positive expression rates of DUSP14 and NRIP1 in cancer tissues of TNBC patients were significantly higher than those in adjacent normal tissues (70.75% vs 12.26%; 76.42% vs 33.96%; both P<0.001). Spearman correlation analysis showed a significant positive correlation between DUSP14 expression and NRIP1 expression in TNBC tissues (r=0.278, P<0.001). The survival analysis showed that the 3-year overall survival rate of DUSP14-positive patients was significantly lower than that of DUSP14-negative patients (37.33% vs 87.10%; χ2=18.165, P<0.001); the 3-year overall survival rate of NRIP1-positive patients was significantly lower than that of NRIP1-negative patients (41.98% vs 84.00%; χ2=11.754, P=0.001). The multivariate COX analysis showed that DUSP14, NRIP1 and TNM stage were affecting factors for the prognosis of TNBC patients (HR=7.736, 10.243, 9.875; 95%CI: 3.739-16.007, 4.845-21.657, 3.620-26.938, all P<0.050).
Conclusion High expressions of DUSP14 and NRIP1 in cancer tissues of TNBC patients indicate a poor prognosis, so DUSP14 and NRIP1 maybe serve as potential therapeutic targets for TNBC.
Key words:
Triple negative breast cancer,
Dual specificity phosphatase 14,
Nuclear receptor interacting protein 1,
Prognosis
Haigang Niu, Wenke Guo. Expressions of dual specific phosphatase 14 and nuclear receptor interacting protein 1 in triple negative breast cancer and their prognostic value[J]. Chinese Journal of Breast Disease(Electronic Edition), 2024, 18(04): 199-205.