To investigate the clinical symptoms and psychological status of female breast cancer patients infected by the Omicron variants of corona virus disease 2019 (COVID-19), and provide a reference for clinical diagnosis, treatment, prevention and control of this disease.

This study was a multicenter cross-sectional study that included 1 150 female breast cancer patients from the breast disease centers of 10 hospitals in 5 provinces in China. All patients were within 28 days after Omicron infection. The questionnaire was produced by the First Affiliated Hospital of Xi’an Jiaotong University and sent to the patients by WeChat. The patients filled in the questionnaire by themselves, which was regarded as patient-reported outcome (PRO) measures. The implementation time was from 8 o’clock on December 27, 2022 to 18 o’clock on December 29, 2022. The survey focused on the COVID-19 vaccination, infection symptoms, diagnosis and treatment, and psychological status of patients. The Generalized Anxiety Disorder-7 (GAD-7) scale was used to assess the level of anxiety in breast cancer patients.

In 1 150 female breast cancer infected by COVID-19, 35.39% (407/1 150) had not been vaccinated against COVID-19, 44.87% (516/1 150) had contact history of COVID-19, and 95.39% (1097/1 150) showed mild symptoms. According to the frequency, the top three symptoms were fever (47.30%, 544/1 150), pharyngalgia (21.57%, 248/1 150) and muscular soreness or arthralgia (9.04%, 104/1 150). Furthermore, GAD-7 score was 48 (31, 44) and 34.35% (395/1 150) showed anxiety to some extent, while 65.04% (748/1 150) had panic disorder. The reasons were listed as follow: fear of disease recurrence or metastasis [61.63%(461/748)], concern about health of family members [51.01%(389/748)] and fear of treatment delay [35.70%(267/748)].

Most of female breast cancer patients with COVID-19 show mild symptoms, but the proportion of patients who have not been vaccinated and the proportion of patients with poor psychological status are high. It is necessary to strengthen COVID-19 vaccination, psychological counseling and health education for breast cancer patients.