To explore the clinical efficacy of minimally invasive lavage and oral administration of traditional Chinese medicine (TCM) in the treatment of plasma cell mastitis.

Based on the inclusion and exclusion criteria, a retrospective study was conducted on clinical data of 100 patients with plasma cell mastitis in the People’s Hospital of Ningxia Hui Autonomous Region from November 2018 to September 2019. Among them, 50 patients were treated with minimally invasive lavage and oral administration of TCM (combined therapy group), and 50 patients were treated with oral administration of TCM only (oral therapy group). The clinical efficacy, score in TCM syndrome scale, score in the Hospital Anxiety and Depression Scale and treatment time were compared between two groups. TCM syndrome score were skewed distributed data, expressed as M(P₂₅-P₇₅). The clinical efficacy was compared by χ² test between two groups, the anxiety and depression scores and treatment time by independent-samples t test, TCM syndrome score by non-parametric test. The anxiety and depression scores of the same group were compared by paired-samples t test before and after treatment, TCM syndrome score by Wilcoxon signed rank test.

The total effective rate in combined therapy group was 96% (48/50), significantly higher than 56% (28/50) in oral therapy group (χ²=21.930, P<0.001). The TCM syndrome score was decreased from 19.0 (18.0-24.3) to 1.0 (1.0-7.0) in combined therapy group (Z=-6.179, P<0.001), from 18.0 (16.0-23.2) to 12.0 (9.7-21.2) in oral therapy group (Z=-6.103, P<0.001). After treatment, the TCM syndrome score in combined therapy group was significantly lower than that in oral therapy group (Z=-5.704, P<0.001). The anxiety score was decreased from 14.4±2.2 to 5.4±2.4 (t=23.862, P<0.001) in combined therapy group, from 13.5± 2.5 to 8.2±3.5 (t=15.499, P<0.001) in oral therapy group. The depression score was decreased from 12.7±2.2 to 4.9±2.4 (t=28.055, P<0.001) in combined therapy group, from 12.5±1.7 to 7.5±2.6 (t=16.390, P<0.001) in oral therapy group. The anxiety and depression scores in combined therapy group were significantly lower than those in oral therapy group (t=4.110, P<0.001; t=4.850, P<0.001). The treatment time in combined therapy group was (14.2±2.3) d, significantly shorter than (22.6±3.0) d in oral therapy group (t=8.420, P<0.001).

Compared with oral administration of TCM, minimally invasive lavage combined with oral administration of TCM has a better efficacy in the treatment of plasma cell mastitis, and it can effectively relieve the anxiety and depression of patients, shorten the treatment time and relieve the pain.