Short-term efficacy and adverse effect of hypofractionated radiotherapy after modified radical mastectomy for breast cancer

doi:10.3877/cma.j.issn.1674-0807.2019.01.010

Chinese Journal of Breast Disease(Electronic Edition) ›› 2019, Vol. 13 ›› Issue (01): 58-59. doi: 10.3877/cma.j.issn.1674-0807.2019.01.010

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Short-term efficacy and adverse effect of hypofractionated radiotherapy after modified radical mastectomy for breast cancer

Jianyong Sun¹(), Yaohong Zhang¹, Senming Chen¹

Received:2017-05-05 Online:2019-02-01 Published:2019-02-01
Contact: Jianyong Sun

Abstract

Jianyong Sun, Yaohong Zhang, Senming Chen. Short-term efficacy and adverse effect of hypofractionated radiotherapy after modified radical mastectomy for breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2019, 13(01): 58-59.

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References 9

[1]	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015 [J]. CA Cancer J Clin，2016，66(2):115-32.
[2]	EBCTCG (Early Breast Cancer Trialists’ Collaborative Group), McGale P, Taylor C, et al. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials [J]. Lancet，2014，383(9935):2127-2135.
[3]	Owen JR, Ashton A, Bliss JM，et al.Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial [J]．Lancet Oncol，2006，7(6):467-471.
[4]	START Trialists’ Group, Bentzen SM, Agrawal RK, et al.The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial [J]．Lancet Oncol，2008，9(4):331-341.
[5]	National Cancer Institute, National Institutes of Health, U．S. Department of Health and Human Services. Common terminology criteria for adverse events (CTCAE) version 4.0[EB/OL]．[2017-04-13]. URL
[6]	Whelan T, MaeKenzie R, Julian J，et al.Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer [J]．J Natl Cancer lnst，2002，94(15):1143-1150.
[7]	Smith BD, Bentzen SM, Correa CR，et al. Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline [J]. Int J Radiat Oncol Biol Phys，2011，81(1):59-68.
[8]	Eldeeb H, Awad I, Elhanafy O. Hypofractionation in post-mastectomy breast cancer patients：seven-year follow-up[J]. Med Oncol，2012，29(4):2570-2576.
[9]	王淑莲，李晔雄，宋永文，等．乳腺癌改良根治术后大分割放疗Ⅰ～Ⅱ期临床试验的近期结果[J]．中华放射肿瘤学杂志，2009，18(3):197-199.

临床特征		例数
临床分期		?
?	Ⅱ期	11
?	Ⅲ期	20
乳腺肿瘤部位		?
?	左侧	17
?	右侧	14
病理类型		?
?	浸润性导管癌	30
?	黏液癌	1
脉管癌栓		?
?	有	6
?	无	25
分子分型		?
?	luminal A型	6
?	luminal B(HER-2阳性)型	4
?	luminal B(HER-2阴性)型	10
?	HER-2过表达型	7
?	三阴型	4
术后腋窝淋巴结转移		?
?	0枚	4
?	1～3枚	13
?	4～9枚	10
?	≥10枚	4

临床特征		例数
临床分期		?
?	Ⅱ期	11
?	Ⅲ期	20
乳腺肿瘤部位		?
?	左侧	17
?	右侧	14
病理类型		?
?	浸润性导管癌	30
?	黏液癌	1
脉管癌栓		?
?	有	6
?	无	25
分子分型		?
?	luminal A型	6
?	luminal B(HER-2阳性)型	4
?	luminal B(HER-2阴性)型	10
?	HER-2过表达型	7
?	三阴型	4
术后腋窝淋巴结转移		?
?	0枚	4
?	1～3枚	13
?	4～9枚	10
?	≥10枚	4

急性反应		例数	发生率(%)
放射性皮炎		?	?
?	Ⅰ度	26	83.9
?	Ⅱ度	5	16.1
放射性肺炎		?	?
?	Ⅰ级	22	71.0
?	Ⅱ级	2	6.5
血液学不良反应		?	?
?	Ⅰ级白细胞计数下降	10	32.3
?	Ⅱ级白细胞计数下降	3	9.7
胸壁疼痛		0	0
疲乏感		3	9.7

急性反应		例数	发生率(%)
放射性皮炎		?	?
?	Ⅰ度	26	83.9
?	Ⅱ度	5	16.1
放射性肺炎		?	?
?	Ⅰ级	22	71.0
?	Ⅱ级	2	6.5
血液学不良反应		?	?
?	Ⅰ级白细胞计数下降	10	32.3
?	Ⅱ级白细胞计数下降	3	9.7
胸壁疼痛		0	0
疲乏感		3	9.7

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