Expressions of B7 homolog 1 and interleukin-2 in breast cancer and their clinical significance

doi:10.3877/cma. j. issn.1674-0807.2015.04.005

Abstract

Abstract:

Objective

To explore the expressions of B7 homolog 1 and interleukin-2 in breast cancer and their clinical significance.

Methods

The clinical data of 75 patients with breast disease in Department of Breast Surgery, the First Affiliated Hospital of China Medical University from June 2012 to September 2014 were retrospectively analyzed, including 44 patients with breast cancer and 31 with benign disease. The paraffin embedded breast tissue samples were collected, and the immunohistochemical method was used to detect the expressions of B7-H1 and IL-2 in different tissues. The positive rate of B7-H1 and IL-2 was compared by χ² test, and χ² test and Fisher exact test were used to analyze the relationship between the expressions of B7-H1,IL-2 and the clinicopathological characteristic of breast cancer.

Results

The positive rate of B7-H1 in breast cancer were significantly higher than that in breast benign lesion [79.6%(35/44) vs 22.6% (7/31),χ² =23.951, P=0.001]. The positive rate of IL-2 in breast cancer were significantly lower than that in breast benign lesion [31.8%(14/44) vs 71.0%(22/31),χ² =11.168, P=0.001]. In 44 patients with breast cancer, the expression of B7-H1 was higher in the specimens with tumor diameter ＞2 cm, higher histological grade, lymph nodes metastasis, HER-2 positive and in TNM stage Ⅲ_A- Ⅳ(χ² =4.589, 7.717, 4.475,15.725,22.211; P=0.032,0.014,0.034,0.000, 0.000), while the expression of IL-2 was lower in the specimens with tumor diameter ＞2 cm, lymph nodes metastasis and in TNM stage Ⅲ_A- Ⅳ(χ² =12.049,14.850,6.147;P=0.001,0.000,0.013).

Conclusion

B7-H1 and IL-2 expressions are correlated with the severity of breast cancer, therefore, the two may serve as the combined indicators for the guidance of comprehensive treatment of breast cancer.

Key words: Apoptosis, B7 homolog 1, Interleukin-2, Breast neoplasms

Xiaopan Zou, Xinyu Zheng. Expressions of B7 homolog 1 and interleukin-2 in breast cancer and their clinical significance[J]. Chinese Journal of Breast Disease(Electronic Edition), 2015, 09(04): 247-251.

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References 9

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临床病理因素	例数	B7-H1表达(例)		χ²值	P值	IL-2表达(例)		χ²值	P值
临床病理因素	例数	阴性	阳性	χ²值	P值	阴性	阳性	χ²值	P值
肿瘤直径
≤2 cm	18	7	11	4.589	0.032^a	7	11	12.049	0.001
＞2 cm	26	2	24	4.589	0.032^a	23	3	12.049	0.001
组织学分级
1级	10	5	5	7.717	0.014^b	6	4	2.383	0.304
2级	14	3	11			8	6	2.383	0.304
3级	20	1	19			16	4
淋巴结转移
无	14	6	8	4.475	0.034^a	4	10	14.850	0.000
有	30	3	27	4.475	0.034^a	26	4	14.850	0.000
ER
阴性	24	2	22		0.057^b	14	10	2.361	0.124
阳性	20	7	13		0.057^b	16	4	2.361	0.124
PR
阴性	29	3	26	3.676	0.055^a	20	9	0.000	1.000^a
阳性	15	6	9	3.676	0.055^a	10	5	0.000	1.000^a
HER-2
阴性	13	8	5	15.725	0.000^a	12	1	3.498	0.061^a
阳性	31	1	30	15.725	0.000^a	18	13	3.498	0.061^a
TNM分期
Ⅰ～Ⅱ_B期	8	7	1	22.211	0.000^a	2	6	6.147	0.013^a
Ⅲ_A～Ⅳ期	36	2	34	22.211	0.000^a	28	8	6.147	0.013^a

临床病理因素	例数	B7-H1表达(例)		χ²值	P值	IL-2表达(例)		χ²值	P值
临床病理因素	例数	阴性	阳性	χ²值	P值	阴性	阳性	χ²值	P值
肿瘤直径
≤2 cm	18	7	11	4.589	0.032^a	7	11	12.049	0.001
＞2 cm	26	2	24	4.589	0.032^a	23	3	12.049	0.001
组织学分级
1级	10	5	5	7.717	0.014^b	6	4	2.383	0.304
2级	14	3	11			8	6	2.383	0.304
3级	20	1	19			16	4
淋巴结转移
无	14	6	8	4.475	0.034^a	4	10	14.850	0.000
有	30	3	27	4.475	0.034^a	26	4	14.850	0.000
ER
阴性	24	2	22		0.057^b	14	10	2.361	0.124
阳性	20	7	13		0.057^b	16	4	2.361	0.124
PR
阴性	29	3	26	3.676	0.055^a	20	9	0.000	1.000^a
阳性	15	6	9	3.676	0.055^a	10	5	0.000	1.000^a
HER-2
阴性	13	8	5	15.725	0.000^a	12	1	3.498	0.061^a
阳性	31	1	30	15.725	0.000^a	18	13	3.498	0.061^a
TNM分期
Ⅰ～Ⅱ_B期	8	7	1	22.211	0.000^a	2	6	6.147	0.013^a
Ⅲ_A～Ⅳ期	36	2	34	22.211	0.000^a	28	8	6.147	0.013^a

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