Abstract:
Objective
To investigate the efficacy of Flupentixol and Melitracen tablets(Deanxit)combined with non-steroidal anti-inflammatory drug in young and middle-aged patients with chronic postoperative pain after breast-conserving surgery of breast cancer.
Methods
Totally 120 patients undergoing breast-conserving surgery in our hospital from March 2011 to September 2012 were enrolled and randomly divided into treatment group (n=60) and control group (n=60). All patients had chronic pain to different degree, with the scores of 8-15 by the hospital anxiety and depression(HAD) scale. Control group was treated with nonsteroidal anti-inflammatory drug Ibuprofen sustained release capsules (Fenbid, 0.3 g, bid), while treatment group took Fenbid plus Flupentixol and Melitracen tablets (1 tablet, bid). The treatment lasted for 8 weeks. At 0, 4, 8 weeks after treatment, the postoperative pain, emotional disorder and sleep quality were assessed using visual analogue scale(VAS),HAD scale,and Pittsburgh sleep quality index (PSQI). The t test and repeated analysis of variance were used to compare measurement data, chi-square test was used to compare the rates.
Results
At 4 weeks and 8 weeks after treatment, in treatment group, VAS showed a significant improvement (F=8.337, P=0.002), the effective rate was higher than that in control group (38.33% vs 20.00%, χ2=4.881,P=0.027; 70.00% vs 36.67%, χ2 =13.393,P＜0.001); the indexes of anxiety and depression were significantly reduced (F=16.825, P＜0.001; F=10.026, P＜0.001), and both were lower than those in control group (F=6.074, P=0.033; F=4.221, P=0.172); PSQI was decreased (F=8.681,P=0.001), but the difference was not statistically significant between two groups (F=3.587, P=0.284).
Conclusion
Flupentixol and Melitracen tablets combined with non-steroidal anti-inflammatory drug show a better efficacy than non-steroidal anti-inflammatory drug used alone in the treatment of chronic pain after breastconserving surgery in young and middle-aged patients with breast cancer, accompanied by the improvement of emotion and sleep quality.
Key words:
Breast neoplasms,
Antianxiety agents,
Antidepressive agents,
Pain, postoperative,
Breast-conserving surgery,
Drug therapy
Yu Wang, Zhi-chao Cui, Jie Ma, Jinghua Zhang, Zheng Gu, Shun-li Zhang. Flupentixol and Melitracen plus non-steroidal anti-inflammatory drug to treat chronic postoperative pain after breast-conserving surgery in young and middle-aged patients with breast cancer: a prospective randomized controlled clinical study[J]. Chinese Journal of Breast Disease(Electronic Edition), 2014, 08(02): 99-102.