Expression of Kiss-1 gene in breast tumor tissues and its clinical significance

doi:10.3877/cma.j.issn.1674-0807.2012.01.005

Abstract

Abstract:

Objective

To evaluate the expression of Kiss-1 mRNA in normal breast tissues and breast tumor tissues and its clinical significance.

Methods

The expression of Kiss-1 mRNA was detected by reverse transcription- polymerase chain reaction (RT-PCR) in normal breast tissues and breast tumor tissues of 70 patients with breast cancer and 40 patients with fibroadenoma.

Results

The expression of Kiss-1 mRNA in breast cancer tissues (0.952±0.576) and fibroadenoma tissues (0.587±0.496) were higher than that in adjacent normal tissues(t=7.917,P=0.00;t=2.656,P=0.011). The expression of Kiss-1 mRNA in breast cancer tissues was higher than that in fibroadenoma tissues (t=3.365,P=0.001). The expression of Kiss-1 mRNA in breast cancer patients with lymph node metastasis (0.662±0.530), was lower than that in patients without lymph node metastasis(1.124±0.537) (t=3.495, P=0.001).

Conclusion

With the relatively high expression in breast tumor tissues, Kiss-1 mRNA may serve as a new marker of breast tumor. The low expression of Kiss-1 mRNA may be related to lymph node metastasis of breast cancer.

Key words: Kiss-1 gene, breast neoplasms, metastasis

Fei XIE, Bo Zhou, De-qi YANG. Expression of Kiss-1 gene in breast tumor tissues and its clinical significance[J]. Chinese Journal of Breast Disease(Electronic Edition), 2012, 06(01): 31-37.

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Figures/Tables 7

References 12

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组织类型	例数	Kiss-1 mRNA相对表达水平	t值	P值
乳腺癌	70	0.952±0.576	7.917	0.000
癌旁正常腺体	70	0.503±0.275

组织类型	例数	Kiss-1 mRNA相对表达水平	t值	P值
乳腺癌	70	0.952±0.576	7.917	0.000
癌旁正常腺体	70	0.503±0.275

组织类型	例数	Kiss-1 mRNA相对表达水平	t值	P值
乳腺纤维腺瘤	40	0.587±0.496	2.656	0.011
瘤旁正常腺体	40	0.423±0.237

组织类型	例数	Kiss-1 mRNA相对表达水平	t值	P值
乳腺纤维腺瘤	40	0.587±0.496	2.656	0.011
瘤旁正常腺体	40	0.423±0.237

组织类型	例数	Kiss-1 mRNA相对表达水平	t值	P值
癌旁正常腺体	70	0.503±0.275	1.528	0.129
瘤旁正常腺体	40	0.423±0.237

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