Research of the expressions of cyclooxygenase-2 and vascular endothelial grow th factor and their effects on tumor angiogenesis in human

doi:10.3877/cma.j.issn.1674-0807.2008.06.008

Abstract

Abstract:

Objective

To study the expressions of cyclooxygenase-2（COX-2）and vascular endothelial growth factor（VEGF）and their effects on tumor angiogenesis in human breast carcinoma.

Methods

The expressions of COX-2 and VEGF were detected in 30 cases of primary breast carcinoma and 20 samples of normal breast tissue by immunohistochemical method.The tumor micrangium was also examined using CD34 staining.

Results

The expression rate of COX-2 and VEGF in breast carcinoma tissue was 70.0%（21／30）and 56.7%（17／30）respectively，with significant difference compared with the nomal breast tissue.A significant correlation was found between COX-2 and VEGF expressions.Both COX-2 and VEGF were significantly correlated with tumor angiogenesis.

Conclusion

Both COX-2 and VEGF are related to tumor angiogenesis in breast cancer.

Key words: Breast carcinoma, Cyclooxygenase-2, Vascular endothelial growth factor

Hui HAN, Shunguo LIN, Chun-sen XU, Wen-xin ZHAO, Da-liang CHEN, Yu-hui ZHENG, Ying-hong YANG. Research of the expressions of cyclooxygenase-2 and vascular endothelial grow th factor and their effects on tumor angiogenesis in human[J]. Chinese Journal of Breast Disease(Electronic Edition), 2008, 02(06): 670-676.

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Figures/Tables 5

References 20

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组织学类型	例数	ＣＯＸ-２阳性表达	ＶＥＧＦ-Ｃ阳性表达
正常组织	２０	２（１０.０）	３（１５.０）
乳腺癌组织	３０	２１（７０.０）^ａ	１７（５６.７）^ｂ

组织学类型	例数	ＣＯＸ-２阳性表达	ＶＥＧＦ-Ｃ阳性表达
正常组织	２０	２（１０.０）	３（１５.０）
乳腺癌组织	３０	２１（７０.０）^ａ	１７（５６.７）^ｂ

ＣＯＸ-２表达	ｎ	ＶＥＧＦ表达（例）		微血管形成
ＣＯＸ-２表达	ｎ	阳性例数（％）	Ｐ值	阳性例数（％）	Ｐ值
阳性	２１	１５（７１.４）	０.０２０	１８（８５.７）	０.００２
阴性	９	２（２２.２）		２（２２.２）

ＣＯＸ-２表达	ｎ	ＶＥＧＦ表达（例）		微血管形成
ＣＯＸ-２表达	ｎ	阳性例数（％）	Ｐ值	阳性例数（％）	Ｐ值
阳性	２１	１５（７１.４）	０.０２０	１８（８５.７）	０.００２
阴性	９	２（２２.２）		２（２２.２）

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