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Chinese Journal of Breast Disease(Electronic Edition) ›› 2025, Vol. 19 ›› Issue (04): 193-197. doi: 10.3877/cma.j.issn.1674-0807.2025.04.001

• Guidelines and Consensus •    

Expert consensus on neoadjuvant immunotherapy for breast cancer (2025 edition)

Expert group for expert consensus on neoadjuvant immunotherapy for breast cancer   

  • Received:2025-05-07 Online:2025-08-01 Published:2025-09-16

Abstract:

With the significant potential of immune checkpoint inhibitors in neoadjuvant treatment for breast cancer,a multidisciplinary expert group was formed to develop this consensus based on the existing evidence-based medical evidences and clinical practice through in-depth discussions. The consensus suggests that pre-positioning of immunotherapy can increase the pathological complete response rate of breast cancer and has the potential for long-term survival benefits. Triple negative breast cancer and hormonal receptor-positive/HER-2-negative breast cancer are the preferred groups for neoadjuvant immunotherapy. Corresponding strategies for drug combinations and subsequent treatment plans are provided. Meanwhile,the expert group confirms that the expression of tumor infiltrating lymphocytes can indicate the efficacy of neoadjuvant immunotherapy. The combination of neoadjuvant immunotherapy and targeted therapy is promising in the treatment of triple negative breast cancer and HER-2 positive breast cancer,but further verification is needed.

Key words: Breast neoplasms, Immunotherapy, Neoadjuvant therapy, Consensus

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