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Chinese Journal of Breast Disease(Electronic Edition) ›› 2023, Vol. 17 ›› Issue (03): 129-135. doi: 10.3877/cma.j.issn.1674-0807.2023.03.001

• Forum of Specialists •     Next Articles

Landscape of antibody-drug conjugates for breast cancer treatment

Xiaowei Qi, Songqing Ye()   

  1. Department of Breast and Thyroid Surgery, First Affiliated Hospital of Army Medical University, Chongqing 400038, China
    Department of Oncology, Fujian Provincial Hospital, Fuzhou 350001, China
  • Received:2023-02-20 Online:2023-06-01 Published:2023-08-04
  • Contact: Songqing Ye

Abstract:

In recent years, antibody-drug conjugate (ADC) has developed rapidly and attracted much attention. As an effective drug for targeted therapy of tumors, ADC has both the powerful lethality of chemotherapy and the high targeting ability of monoclonal antibody drugs, showing better efficacy and fewer side effects. In the field of breast cancer, three ADC products have been approved for marketing in China, which are gradually changing the landscape of breast cancer treatment. This article summarizes the development process of ADC, the therapeutic pattern reshaping of breast cancer, and future prospect of ADC application, so as to provide new insights for clinical application and research of ADC.

Key words: Breast neoplasms, Human epidermal growth factor receptor-2, Antibody-drug conjugates

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