Radiotherapy following breast reconstruction using a pedicled omental flap combined with a silicone implant in dogs

doi:10.3877/cma.j.issn.1674-0807.2023.02.006

Abstract

Abstract:

Objective

To investigate the effect of radiotherapy on breast reconstruction using the pedicled omental flap combined with a silicone implant in experimental dogs.

Methods

Twenty healthy local dogs were used for the experiment. Each experimental dog underwent 2 types of breast reconstruction in anterior ventral breasts. They underwent breast reconstruction using a pedicled omental flap and a silicone implant in the left breast (the omental flap group), and prosthetic breast reconstruction only with a silicone implant in the right breast (the implant group). Four weeks after surgery, radiotherapy of the same dose was given for both breasts. Eight months after radiotherapy, the omental flap, implants and capsules were removed from the dogs. The rate of capsular contracture was compared between groups by paired χ² test (McNemar test). The thickness of capsule and microvascular density were compared between groups by paired-samples t test.

Results

The capsular contracture rate in the implant group and the omental flap group was 25.0% (5/20) and 5.0% (1/20), respectively, indicating no significant difference (χ²=2.670, P=0.219). Thickness of the capsule in the implant group was significantly higher than that in the omental flap group [ (1.4±0.2) mm vs (0.8±0.1) mm, t=4.173, P=0.001]. Microvascular density in the omental flap group was significantly higher than that in the implant group (vessels in each high power field: 44.3±5.1 vs 28.4±2.8, t=5.202, P<0.001).

Conclusion

Radiotherapy shows little effect on breast reconstruction with a pedicled omental flap and a silicone implant in experimental dogs and the omentum has a protective effect on the silicone implant.

Key words: Breast neoplasms, Omentum, Prostheses and implants, Dogs, Radiotherapy

Lingli Lu, Hao Liu, Ying Hu, Xiao He, Hongwu Deng, Ying He, Yi Zhang, Yong Wang, Nengbin Wan. Radiotherapy following breast reconstruction using a pedicled omental flap combined with a silicone implant in dogs[J]. Chinese Journal of Breast Disease(Electronic Edition), 2023, 17(02): 97-101.

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