Computer-assisted 3-dimensional printing technology for immediate breast reconstruction after breast-conserving surgery

doi:10.3877/cma.j.issn.1674-0807.2018.01.003

Abstract

Abstract:

Objective

To explore the application of 3-dimensional (3D) printed biodegradable implants in immediate breast reconstruction after breast-conserving surgery in breast cancer patients.

Methods

One patient with left invasive breast cancer (4.0 cm×3.0 cm), who was admitted in Xijing Hospital, Medical University of Air Force on March 6, 2016, underwent breast-conserving surgery and immediate breast reconstruction. The bio-implant produced by computer-assisted 3D printing technology was used for reconstruction. Imaging data of the breast were collected by breast MRI (plain scanning and enhancement scanning) before operation. The computer simulation was performed to calculate the tissue defect and design the implants meticulously. After data input, the bio-implant was printed by the 3D printer system developed by Xian Jiaotong University, using porous biodegradable material-polycaprolactone. Following sufficient sterilization, the bio-implant was inserted into the defective cavity after tumor resection. Safety indicators (implant-related infection and immunological rejection), cosmetic outcome, autologous compatibility and prognosis were evaluated every month after surgery.

Results

After breast reconstruction, no major complications including infection and hematoma occurred and the wound healed smoothly. Nine months after operation, the breast showed excellent cosmetic outcome and MRI demonstrated good compatibility of implant with autologous tissue. The functional imaging showed that with rich blood supply around, bio-implant was surrounded by soft tissue and some granulation tissue gradually grew into the implant. Until December 2017, no local recurrence and metastasis were reported.

Conclusion

The 3D-printed biodegradable soft tissue material may provide a new way for breast reconstruction after breast-conserving surgery, and is worthy of clinical application.

Key words: Breast neoplasms, Mammaplasty, Three-dimensional printing

Juliang Zhang, Qing Yao, Meiling Huang, Mingkun Zhang, Huimin Meng, Lan Hou, Rui Ling. Computer-assisted 3-dimensional printing technology for immediate breast reconstruction after breast-conserving surgery[J]. Chinese Journal of Breast Disease(Electronic Edition), 2018, 12(01): 12-16.

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