Abstract:

Objective

To evaluate the accuracy of bioelectrical impedance spectroscopy (BIS) in rapidly distinguishing malignant breast mass from benign mass.

Methods

We selected the specimens from 237 breast masses in 189 patients from January 2015 to June 2016 in the Third People's Hospital of Chengdu(the Affiliated Hospital of Southwest Jiaotong University) for clinical trials. Each specimen was detected sequentially by Breast Tissue Bioimpedance Analyser (MScan1.0B) and pathological examination of paraffin sections. With pathological results as gold standard, the specificity and sensitivity of MScan1.0B detection were evaluated. McNemar χ² test was used to analyze the difference between MScan1.0B and pathological examination. Kappa test was used to check the consistency of the two methods.

Results

The sensitivity of BIS was 93.75%(45/48), the specificity 96.30%(182/189), false positive rate 3.70%(7/189), false negative rate 6.25% (3/48), positive likelihood ratio 25.31 and negative likelihood ratio 0.06. There was no significant difference in detection efficacy between the two methods (P=0.344). BIS technique had high consistence with pathologic examination (Kappa=0.87,P＜0.001).

Conclusion

BIS can identify the benign and malignant breast masses with advantages of high accuracy, low cost, high efficiency and simple operation,which overcomes the shortcomings of intraoperative frozen section biopsy and has potential as a supplementary method of pathological examination for clinical identification.

Key words: Breast neoplasms, Diagnosis, Monitoring,intraoperative, Electric impedance