Abstract:

Objective

To compare the pathological indicators and biological markers between ductal carcinoma in situ(DCIS) and DCIS with microinvasion(DCIS-MI)for investigating the possible pathological and biological alterations during the progression of DCIS to DCIS-MI.

Methods

Forty patients with DCIS and 30 patients with DCIS-MI were retrospectively analyzed. Pearson χ² test was applied for comparison of the pathological indicators of the intraductal components between DCIS and DCIS-MI. Wilcoxon rank sum test was used for comparison of the differences of biological markers as estrogen receptor (ER),progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), P53 and Ki67 between DCIS and DCIS-MI.

Results

For the pathological type, comedo and noncomedo types were 25.0%(10/40)and 75.0%(30/40)in the DICS group, and 63.3%(19/30) and 36. 7%(11/30) in the DCIS-MI group, respectively; and there was statistically significant difference between the two groups(χ²=10. 38,P=0. 001). The proportions of high nuclear grade and necrosis were significantly higher in the DCIS-MI group than in the DICS group(χ²=9.52,P=0.009;χ²=8.572,P=0.003). There were no differences in the expressions of ER, PR, HER-2 and P53 between the DCIS and the DCIS-MI groups (P＞0.050).But Ki67 index was significantly higher in the DCIS-MI group than in the DICS group(40.0% vs 17.5%,Z=-2. 351,P=0. 019).

Conclusion

Cell proliferation capacity and expression of Ki67 may have a role to predict the progression of DCIS to DCIS-MI.

Key words: breast neoplasms, ductal carcinoma in situ, microinvasive carcinoma, P53, Ki67