Abstract:

Objective

To explore the expressions of serum interlueukin-8(IL-8)and cyclooxygenase-2(COX-2)in triple negative breast cancer patients before and after surgery and their clinical significance.

Methods

Specimens from 72 triple negative breast cancer patients(the breast cancer group)and 54 patients with benign breast mass (the control group)before and after operation were selected.The expressions of IL-8 and COX-2 in both groups before and after surgery were assessed using enzyme linked immunosorbent assay-sandwich technique(ELISA).Student's t test was used for the comparison of the expressions of IL-8 and COX-2 between the two groups,and paired t test was used for the comparison between pre-operation and post-operation.

Results

Before surgery the expression levels of IL-8 and COX-2 in the breast cancer group was markedly higher than in the control group(both P=0.000),but after operation there was no statistical difference between the two groups(both P＞0.050).The expression levels of IL-8 and COX-2 before operation were higher than after operation in the breast cancer group(both P=0.000).Among the 72 breast cancer patients,postoperative recurrence occurred in 4,and their IL-8 and COX-2 expression levels were higher than those of the nonrecurrence patients(both P＞0.050).

Conclusions

The changes of the expressions of IL-8 and COX-2 in triple negative breast cancer patients before and after operation are obvious and may be helpful to judge therapeutic effect.

Key words: Breast neoplasms, IL-8, COX-2, Enzyme linked immunosorbent assay