Abstract:

Objective

To st udy t he accuracy and clinical application val ue of fine needle aspiration cytol ogy(FNAC)in diagnosing breast t u mors.

Methods

FNAC was perf or med on 1193 cases with breast lesions,and 267 of t he m were subjected to histopat hol ogy diagnosis as well.The FNAC and histopathological diagnosis results were co mpared and anal yzed.The correlation bet ween FNAC results and age of patients,original region and size of tu mor was analyzed by chisquare test.

Results

Of the 1193 fine needle aspiration samples,886(74.3%)were diagnosed as grade I,228(19.1%)as Grade II,44(3.6%)as Grade III,and 35(2.9%)as grade IV.FNAC positive proportion(Grade III+Grade IV)didn't correlate with the age of patients,original region and size of tumor.Among them,267 cases were studied with histopathology as well.The sensitivity and the specificity of malignant tumor were 92.9% (79/85)and 100% (182/182),respectively.The positive likelihood ratio was infinite,and the negative likelihood ratio was 0.07,the Youden index was 0.93,the false negative rate were 7.0%(6/85),no false positive diagnosis was found.

Conclusions

FNAC has high accu-racy in diagnosing breast tumors,and is of clinical significance in guiding diagnosis and treatment.

Key words: Breast neoplasmas, Biopsy, Needle aspiration