Effects of breast-associated physiological and pathological factors on female breast cancer

doi:10.3877/cma.j.issn.1674-0807.2008.05.004

Abstract

Abstract:

Objective

To study the effects of breast-associated physiological and pathological risk factors on female breast cancer in order to provide a basis for prevention and treatment of breast cancer.

Methods

A case control study was carried out. From January 1997 to April 2007 200 female patients with breast cancer diagnosed by pathohistological examination and 200 non-breast cancer agematched women were questionnaired. SPSS 10. 0 was used to analyze the data.

Results

Univariate and multivariate logistic regression showed that greater body mass index (BMI) , late menopause, hyperplasia of mammary glands and family history of breast cancer were positively related to breast cancer; long menstrual period was negatively related to breast cancer.

Conclusions

Greater BMI, late menopause, hyperplasia of mammary glands and family history of breast cancer are risk factors for breast cancer; long menstrual period is a protective factor.

Key words: Breast neoplasms, Risk factor, Case-control study

Jianyun NIE, Cong-guo JIN, Yi-yin TANG, Wen-lin CHEN, Mao-hua WANG, Kai ZHENG. Effects of breast-associated physiological and pathological factors on female breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2008, 02(05): 14-17.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhrxbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0807.2008.05.004

https://zhrxbzz.cma-cmc.com.cn/EN/Y2008/V02/I05/14

Figures/Tables 3

References 12

[1]	Zheng W, Xie D, Cerhan J R, et al. Sulfotransferase 1A1 poly-morphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk. Cancer Epidemiol Biomarkers Prev,2003,10:89 -94.
[2]	Chen W Y, Hankinson S E, Schnitt S J, et al. Association of hormone replacement therapy to estrogen and progesterone receptor status in invasive breast carcinoma. Cancer,2003,101:1490 -1500.
[3]	袁宝君,戴月,史祖民,等.妇女乳腺癌危险因素病例对照研究.中国公共卫生,2004,20:1036 -1036.
[4]	韩定芬,马骏,周新,等.武汉地区女性乳腺癌危险因素的病例对照研究.中华流行病学杂志,2004,25:256 -260.
[5]	郑莹,李德像,向泳梅. 上海市区乳腺癌流行现状及趋势分析.外科理论与实践,2001,6:219 -221.
[6]	Feigelson H S, Jonas R, Teras L R, et al. Weight gain, body mass index, hormone replacement therapy, and postmenopausal breast cancer in a large prospective study. Cancer Epidemiol Biomarkers Prev,2004,13:220 -224.
[7]	Daling J R, Malone K E, Doody D R, et al. Association of regimens of hormone replacement therapy to prognostic factors among women diagnosed with breast cancer aged 50 - 64 years. Cancer Epidemiol Biomarkers Prev, 2003, 12:1175 -1181.
[8]	Vachon C M, Sellers T A, Vierkant R A, et al. Case-control study of increased mammographic breast density response to hormone replacement therapy. Cancer Epidemiol Biomarkers Prev,2002,11:1382 -1388.
[9]	Pike M C, Kolonel L N, Henderson B E, et al. Breast cancer in a multiethnic cohort in Hawaii and Los Angeles: risk factor adjusted incidence in Japanese equals and in Hawaiians exceeds that in whites. Cancer Epidemiol Biomarkers Prev,2006,11:795 -800.
[10]	Brewster D H, Stockton D L, Dobbie R, et al. Risk of breast cancer after miscarriage or induced abortion: a Scottish record linkage case-control study. J Epidemiol Community Health,2005,59:283 -287.
[11]	Dite G S, Jenkins M A. Southey M C, et al. Familial risks,early onset breast cancer, and BRCA1 and BRCA2 germline mutations. J Natl Cancer Inst,2003,96:448 -457.
[12]	Spurdle A B, Hopper J L. Dite G S, et al. CYP17 promoter polymorphism and breast cancer in Australian women under age forty years. J Natl Cancer Inst,2000,92:1674 -1681.

因素	对照组	乳腺癌组	P值
年龄
平均年龄/岁	43.87	42.76	＞0.05
小于30岁/例	3	2	＞0.05
30～40岁/例	33	31	＞0.05
40～50岁/例	99	104	＞0.05
50～60岁/例	34	32	＞0.05
60～70岁/例	28	27	＞0.05
大于70岁/例	3	4	＞0.05
体重指数	20.50	24.51	＜0.05
初次月经年龄/岁	13.69	12.54	＜0.05
月经持续天数/d	3.72	2.61	＜0.05
绝经人数/例	93	88	＞0.05
绝经年龄/岁	44.80	52.45	＜0.05
哺乳时间/月	12.18	8.39	＜0.05
怀孕次数/次	2.17	2.44	＞0.05
流产次数/次	0.87	1.13	＜0.05
避孕药使用/例	35	25	＞0.05
乳腺增生/例	77	154	＜0.05
乳腺腺瘤/例	17	35	＜0.05
乳腺囊肿/例	55	59	＞0.05
乳癌家族史/例	5	33	＜0.05

因素	对照组	乳腺癌组	P值
年龄
平均年龄/岁	43.87	42.76	＞0.05
小于30岁/例	3	2	＞0.05
30～40岁/例	33	31	＞0.05
40～50岁/例	99	104	＞0.05
50～60岁/例	34	32	＞0.05
60～70岁/例	28	27	＞0.05
大于70岁/例	3	4	＞0.05
体重指数	20.50	24.51	＜0.05
初次月经年龄/岁	13.69	12.54	＜0.05
月经持续天数/d	3.72	2.61	＜0.05
绝经人数/例	93	88	＞0.05
绝经年龄/岁	44.80	52.45	＜0.05
哺乳时间/月	12.18	8.39	＜0.05
怀孕次数/次	2.17	2.44	＞0.05
流产次数/次	0.87	1.13	＜0.05
避孕药使用/例	35	25	＞0.05
乳腺增生/例	77	154	＜0.05
乳腺腺瘤/例	17	35	＜0.05
乳腺囊肿/例	55	59	＞0.05
乳癌家族史/例	5	33	＜0.05

因素	对照组(200例)	乳腺癌组(200例)	回归系数	P值	优势比(OR值)	OR值95%可信区间
体重指数	20.50	24.51	0.173	0.000	1.189	1.134～1.246
初次月经年龄/岁	13.69	12.54	-0.449	0.000	0.638	0.557～0.731
月经持续天数/d	3.72	2.61	-0.898	0.000	0.407	0.323～0.517
绝经年龄/岁	44.80	52.45	0.166	0.002	1.181	1.061～1.314
哺乳时间/月	12.18	8.39	-0.090	0.000	0.914	0.885～0.945
怀孕次数/次	2.17	2.44	-0.045	0.411	0.956	0.858～1.065
流产次数/次	0.87	1.13	0.193	0.019	1.213	1.033～1.425
避孕药/例	35	25	-0.375	0.174	0.688	0.401～1.180
乳腺增生/例	77	154	1.958	0.000	7.082	4.332～11.576
乳腺腺瘤/例	17	35	0.771	0.011	2.162	1.196～3.910
乳腺囊肿/例	55	59	0.069	0.747	1.072	0.703～1.633
乳癌家族史/例	5	33	1.925	0.000	6.855	2.814～16.701

因素	对照组(200例)	乳腺癌组(200例)	回归系数	P值	优势比(OR值)	OR值95%可信区间
体重指数	20.50	24.51	0.173	0.000	1.189	1.134～1.246
初次月经年龄/岁	13.69	12.54	-0.449	0.000	0.638	0.557～0.731
月经持续天数/d	3.72	2.61	-0.898	0.000	0.407	0.323～0.517
绝经年龄/岁	44.80	52.45	0.166	0.002	1.181	1.061～1.314
哺乳时间/月	12.18	8.39	-0.090	0.000	0.914	0.885～0.945
怀孕次数/次	2.17	2.44	-0.045	0.411	0.956	0.858～1.065
流产次数/次	0.87	1.13	0.193	0.019	1.213	1.033～1.425
避孕药/例	35	25	-0.375	0.174	0.688	0.401～1.180
乳腺增生/例	77	154	1.958	0.000	7.082	4.332～11.576
乳腺腺瘤/例	17	35	0.771	0.011	2.162	1.196～3.910
乳腺囊肿/例	55	59	0.069	0.747	1.072	0.703～1.633
乳癌家族史/例	5	33	1.925	0.000	6.855	2.814～16.701

因素	对照组(200例)	乳腺癌组(200例)	回归系数	P值	优势比(OR值)	OR值95%可信区间
体重指数	20.50	24.51	0.190	0.012	1.209	1.042～1.403
月经持续天数/d	3.72	2.61	-0.928	0.004	0.395	0.210～0.745
绝经年龄/岁	44.80	52.45	0.446	0.001	1.562	1.200～2.033
哺乳时间/月	12.18	8.39	-0.060	0.130	0.941	0.871～1.018
乳腺增生/例	77	154	2.723	0.000	15.226	3.604～64.326
乳腺腺瘤/例	17	35	-1.949	0.062	0.142	0.018～1.106
乳癌家族史/例	5	33	2.376	0.004	10.757	1.612～189.088

Please choose a citation manager

Content to export