Abstract:

Objective

To compare long term therapeutic effect of preoperative chemotherapy through internal mammary artery versus system chemotherapy on patients suffering from local advanced breast cancer.

Methods

Eighty-five cases of local advanced breast cancer with same stage were randomly divided into a therapy group （ n =41） and a control group （ n =44）.The patients were given preoperative local chemotherapy through internal mammary artery in the therapy group and system chemotherapy via peripheral veins in the control group.After operation radiotherapy and intravenous chemotherapy were performed.All patients were followed up for 5 years.Local recurrence， bone metastasis， hepatic metastasis， thoracic metastasis and the survival of 1， 3 and 5 years in the two groups were statistically analyzed.

Results

The local recurrence， bone metastasis， hepatic metastasis， thoracic metastasis occurred in 11， 6， 7 and 2 cases respectively in the therapy group， and in 11， 5， 10 and 10 cases respectively in the control group.The survival rates of 1， 3 and 5 years were 100% ， 90.2% and 80.5% respectively in the therapy group， and 95.5% ，77.3% and 59.1% respectively in the control group.

Conclusions

The preoperative chemotherapy via internal mammary artery can decrease thoracic metastasis and raise 5 year survival rate for local advanced

breast cancer.

Key words: Breast neoplasm, Internal mammary artery, Preoperative chemotherapy