Effect of preoperative regional intra-arterial infusion chemo-therapy on MVD and LMVD in advanced breast cancer

doi:10.3877/cma.j.issn.1674-0807.2007.03.008

Abstract

Abstract:

Objective

To investigate the different effect between preoperative regional intra-arterial infusion chemotherapy and preoperative intra-venous infusion chemotherapy on microvessel density（MVD）and lymphatic microvessel density（LMVD）in advanced breast cancer.

Methods

Seventy-six breast cancer patients were divided into 2 groups：the preoperative regional intra-arterial infusion chemotherapy group（PIAC group，35 cases），and the preoperative intra-venous infusion chemotherapy group（PIVC group，41 cases）；and another 25 breast cancer patients without preoperative chemotherapy were as the control group.Using SP immunostaining method，MVD and LMVD of the samples of breast cancer in the 3 groups were detected with CD34 and VEGFR3.

Results

MVD was 36.05±13.64 in the PIAC group，49.92±12.90 in the PIVC group and 11.30±5.32 in the control group；there was a significant diffe rence in comparison of the 3 groups（P﹤0.01）.MLVD was 6.62±3.70 in the PIAC group，9.96±4.57 in the PIVC group and 11.30±5.32 in the control group，it was remarkably decreased in the PIAC group compared with the control group，there was a significant difference between the two groups（P﹤0.01），the difference between the PIAC group and the PIVC group was statistically significant（P﹤0.05）while the difference between the PIVC group and the control group was not statistically significant（P﹥0.05）.

Conclusion

PIAC can more effectively reduce MVD and MLVD than PIVC，thus restraining the growth of cancer cells and reducing cancer metastasis.

Key words: Breast neoplasms, Intra-arterial infusion chemotherapy, Microvessel density, Microlyphtic vessel density

Xiao-jun MA, Yong-dong PU, Jian-miao HE, Xiu-kun ZHAO. Effect of preoperative regional intra-arterial infusion chemo-therapy on MVD and LMVD in advanced breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2007, 01(03): 24-27.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhrxbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0807.2007.03.008

https://zhrxbzz.cma-cmc.com.cn/EN/Y2007/V01/I03/24

Figures/Tables 4

References 8

［1］	Kitagawa K，yamakado K，Nakatsuka A，et al.Properative transcatheter arterial infusion chemotherapy for locally advanced breast cancer（stage Ⅲb）for down-staging and increase of resectability.Eur J Radiol，2002，43：31-36.
［2］	徐工学，李志霞，陈佛来，等.术前区域性动脉灌注化疗对大肠癌细胞凋亡之相关基因的影响.中华外科杂志，2001，39：436-439.
［3］	Fiorentini G，tsetis D，Bernardeschi P，et al.First-line intra-arterial chemotherapy（IAC）with epirubicin and mitoxantrone in locally advanced breast cancer.Anticancer Res，2003，23：4339.
［4］	甘长清，苏新良，杨光伦，等.经尺动脉介入化疗治疗局部晚期乳腺癌27例临床分析.重庆医学，2005，34：407-408.
［5］	何建苗，蒲永东，曹志宇，等.晚期乳腺癌术前局部灌注化疗的疗效观察.中国普通外科杂志，2003，12：329-331.
［6］	Witte D，Thomoas A，Ali N，et al.Expression of the vascular endothelial growth factor receptor-3（VEGFR-3）and its ligand VEGF-C in human colorectal adenocarcinoma.Anticancer Res，2002，22：1463-1466.
［7］	Shushanov S，Bronetein M，Adelaide J，et al.VEGF-C and VEGFR-3 expression in human thyriod pathyrologies.Int J Cancer，2000，86：47-52.
［8］	陈珊，金伟，闵平，等.血管内皮生长因子家族及其受体与肿瘤血管生成研究进展.生命科学，2004，16：19-23.

临床因素	静脉化疗组	动脉化疗组	P值
病理类型			0.487 0
浸润性导管癌（例）	17	20
腺癌（例）	8	6
乳头状癌（例）	5	4
单纯癌（例）	6	2
硬癌（例）	4	2
湿疹样癌（例）	1	1
TNM分期			0.466 8
Ⅲ期（例）	33	26
Ⅳ期（例）	8	9
年龄/岁	57.4±8.7	54.9±10.8	0.346 3
化疗后肿瘤平均直径/cm	3.3±1.4	3.4±1.3	0.768 9
术后淋巴结转移数	4.2±3.3	4.9±6.1	0.627 8

临床因素	静脉化疗组	动脉化疗组	P值
病理类型			0.487 0
浸润性导管癌（例）	17	20
腺癌（例）	8	6
乳头状癌（例）	5	4
单纯癌（例）	6	2
硬癌（例）	4	2
湿疹样癌（例）	1	1
TNM分期			0.466 8
Ⅲ期（例）	33	26
Ⅳ期（例）	8	9
年龄/岁	57.4±8.7	54.9±10.8	0.346 3
化疗后肿瘤平均直径/cm	3.3±1.4	3.4±1.3	0.768 9
术后淋巴结转移数	4.2±3.3	4.9±6.1	0.627 8

组别	完全缓解（例）	部分缓解（例）	稳定（例）
动脉灌注化疗组^a	12	21	2
全身静脉化疗组	6	32	3

组别	完全缓解（例）	部分缓解（例）	稳定（例）
动脉灌注化疗组^a	12	21	2
全身静脉化疗组	6	32	3

并发症	动脉灌注化疗组（例）	全身静脉化疗组（例）	P值
消化道症状	5	8	0.075 7
脱发	4	12	0.000 9
骨髓抑制	3	9	0.039 5
其他	5	3	0.278 9

Please choose a citation manager

Content to export