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中华乳腺病杂志(电子版) ›› 2026, Vol. 20 ›› Issue (02) : 104 -108. doi: 10.3877/cma.j.issn.1674-0807.2026.02.005

综述

妊娠相关乳腺癌发病机制及诊疗研究进展
李会霞, 王文东, 杜鹏, 邢文豪, 刘悦琦, 密雪芳, 邓萌, 葛新()   
  1. 450052 郑州,郑州大学第一附属医院乳腺外科
  • 收稿日期:2025-04-16 出版日期:2026-04-01
  • 通信作者: 葛新
  • 基金资助:
    河南省自然科学基金青年项目(202300410395)

Pathogenesis, diagnosis and treatment of pregnancy-associated breast cancer

Huixia Li, Wendong Wang, Peng Du   

  • Received:2025-04-16 Published:2026-04-01
引用本文:

李会霞, 王文东, 杜鹏, 邢文豪, 刘悦琦, 密雪芳, 邓萌, 葛新. 妊娠相关乳腺癌发病机制及诊疗研究进展[J/OL]. 中华乳腺病杂志(电子版), 2026, 20(02): 104-108.

Huixia Li, Wendong Wang, Peng Du. Pathogenesis, diagnosis and treatment of pregnancy-associated breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2026, 20(02): 104-108.

妊娠相关乳腺癌(PABC)是指女性在妊娠期或分娩后1年内确诊的乳腺癌,具有起病隐匿、进展较快及预后相对不良等特点。受妊娠及哺乳期乳腺生理性改变和激素水平波动的影响,PABC的早期诊断和规范治疗面临诸多挑战。近年来,随着分子生物学、影像学及多学科诊疗模式的发展,PABC在发病机制及诊疗方面取得一定进展。本文从基因突变与遗传因素、激素分泌异常、乳腺组织重塑、免疫微环境与炎症反应及电离辐射等方面分析PABC的发病机制,并深入阐述其诊断和治疗的最新研究进展,以期为临床实践和进一步研究提供参考。

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