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中华乳腺病杂志(电子版) ›› 2023, Vol. 17 ›› Issue (05) : 305 -308. doi: 10.3877/cma.j.issn.1674-0807.2023.05.009

综述

乳腺癌组织微生物群特征研究进展
吴雪烁, 冯景, 周毅()   
  1. 150001 哈尔滨医科大学附属第一医院乳腺外科
  • 收稿日期:2021-09-19 出版日期:2023-10-01
  • 通信作者: 周毅

Microbiome characteristics of breast cancer tissue

Xueshuo Wu, Jing Feng, Yi Zhou()   

  • Received:2021-09-19 Published:2023-10-01
  • Corresponding author: Yi Zhou
引用本文:

吴雪烁, 冯景, 周毅. 乳腺癌组织微生物群特征研究进展[J/OL]. 中华乳腺病杂志(电子版), 2023, 17(05): 305-308.

Xueshuo Wu, Jing Feng, Yi Zhou. Microbiome characteristics of breast cancer tissue[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2023, 17(05): 305-308.

研究发现乳腺组织中也存在特殊的微生物群,其组成与丰度可能随着乳腺疾病类型和病情进展情况而发生特异性变化。乳腺癌患者微生物群失调作为一个新的风险因素与乳腺癌发展过程密切相关,并且显示出作为预后和预测性生物标志物的巨大潜力。随着微生物研究逐渐深入到单菌功能分析层面,局部组织微生物群在微环境中的组成和代谢变化在肿瘤发生、发展过程中扮演重要角色。本文旨在总结近年研究成果,描述乳房组织定植的独特微生物群,比较乳腺癌组织、正常乳房组织以及非癌性良性病变的微生物群差异,分析这种生态失调在乳腺癌发病过程中的作用,以及对微环境免疫功能和代谢变化的影响。

[1]
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020[J]. CA Cancer J Clin202070(1):7-30.
[2]
Loibl S, Poortmans P, Morrow M, et al. Breast cancer[J]. The Lancet, 2021397(10286):1750-1769.
[3]
Fernández MF, Reina-Pérez I, Astorga JM, et al. Breast cancer and its relationship with the microbiota[J]. Int J Environ Res Public Health201815(8):1747.
[4]
Sepich-Poore GD, Zitvogel L, Straussman R, et al. The microbiome and human cancer[J]. Science2021371(6536): eabc4552.
[5]
Eslami-SZ, Majidzadeh-AK, Halvaei S, et al. Microbiome and breast cancer: new role for an ancient population[J]. Front Oncol202010:120.
[6]
Thomas RM, Jobin C. The microbiome and cancer: is the oncobiome mirage real? [J]. Trends Cancer20151(1):24-35.
[7]
Vasan N, Baselga J, Hyman DM. A view on drug resistance in cancer[J]. Nature575(7782):299-309.
[8]
Wallace BD, Wang H, Lane KT, et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme[J]. Science2010, 330(6005):831-835.
[9]
Jarman R, Ribeiro-Milograna S, Kalle W. Potential of the microbiome as a biomarker for early diagnosis and prognosis of breast cancer[J]. Breast Cancer202023(6): 579-587.
[10]
Banerjee S, Tian T, Wei Z, et al. Distinct microbial signatures associated with different breast cancer types[J]. Front Microbiol20189(1):951.
[11]
Jost TLacroix C, Braegger C, et al. Impact of human milk bacteria and oligosaccharides on neonatal gut microbiota establishment and gut health[J]. Nutr Rev201573(7):426-437.
[12]
Chan AA, Bashir M, Rivas MN, et al. Characterization of the microbiome of nipple aspirate fluid of breast cancer survivors[J]. Sci Rep20166(6):28061.
[13]
Costantini L, Magno S, Albanese D, et al. Characterization of human breast tissue microbiota from core needle biopsies through the analysis of multi hypervariable 16S-rRNA gene regions[J]. Sci Rep20188(1):16893.
[14]
Thompson KJ, Ingle JN, Tang X, et al. A comprehensive analysis of breast cancer microbiota and host gene expression[J]. PLoS ONE201712(11):e0188873.
[15]
Tina J, Chen J, Tanya L, et al. The microbiome of aseptically collected human breast tissue in benign and malignant disease[J]. Sci Rep20166(8): 30751.
[16]
Tzeng A, Sangwan N, Jia M, et al. Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer[J]. Genome Med202113(1): 60.
[17]
Chiba A, Bawaneh A, Velazquez C, et al. Neoadjuvant chemotherapy shifts breast tumor microbiota populations to regulate drug responsiveness and the development of metastasis[J]. Mol Cancer Res202018(1):130-139.
[18]
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation[J]. Cell2011144(5):646-74.
[19]
Alpuim Costa D, Nobre JG, Batista MV, et al. Human microbiota and breast cancer-is there any relevant link? —a literature review and new horizons toward personalised medicine[J]. Front Microbiol202112(2):584332.
[20]
Gatti-Mays ME, Balko JM, Gameiro SR, et al. If we build it they will come: targeting the immune response to breast cancer[J]. NPJ Breast Cancer20195(1):37.
[21]
Ali HR, Provenzano E, Dawson SJ, et al. Association between CD8+ T-cell infiltration and breast cancer survival in 12439 patients[J]. Ann Oncol201425(8):1536-1543.
[22]
Safarzadeh E, Hashemzadeh S, Duijf PHG, et al. Circulating myeloid-derived suppressor cells: an independent prognostic factor in patients with breast cancer[J]. Cell Physiol2019, 234(4): 3515-3525.
[23]
Pinto ML, Rios E, Durães C, et al. The two faces of tumor associated macrophages and their clinical significance in colorectal cancer[J]. Front Immunol2019, 10(1):1875.
[24]
Zhao X, Qu J, Sun Y, et al. Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature[J]. Oncotarget2017, 8(18):30576-30586.
[25]
Parida S, Wu S, Siddharth S, et al. A pro-carcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates notch and β-catenin axes[J]. Cancer Discov202111(5):1138-1157.
[26]
Nejman DLivyatan IFuks G,et al.The human tumor microbiome is composed of tumor type-specific intracellular bacteria[J].Science2020368(6494):973-980.
[27]
Parhi L, Alon-Maimon T, Sol A, et al. Breast cancer colonization by fusobacterium nucleatum accelerates tumor growth and metastatic progression[J]. Nat Commun202011(1): 3259.
[28]
Gur C, Maalouf N, Shhadeh A, et al. Fusobacterium nucleatum supresses anti-tumor immunity by activating CEACAM1[J]. Oncoimmunology, 2019, 8(6):e1581531.
[29]
Gopalakrishnan V, Helmink BA, Spencer CN, et al. The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy[J]. Cancer Cell201833(4):570-580.
[30]
Raza MH, Gul K, Arshad A, et al. Microbiota in cancer development and treatment[J]. Cancer Res Clin Oncol2019145(1):49-63.
[31]
Geier B, Sogin EM, Michellod D, et al. Spatial metabolomics of in situ host-microbe interactions at the micrometre scale[J]. Nat Microbiol20205(3):498-510.
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