目的

探讨Qontraxt超声造影定量分析软件在乳腺肿瘤诊断中的临床应用价值。

方法

对73例患者78枚乳腺病灶进行常规超声和超声造影检查，采用Qontraxt软件分析造影参数成像图及时间强度曲线特征，并与病理检查结果对照。

结果

病理检查结果显示78枚乳腺病灶中恶性病灶47枚，良性病灶31枚。恶性病灶造影参数彩图示造影剂峰值强度高低不等，达峰时间长短不一。而良性病灶造影参数彩图颜色单一，病灶每个区达峰时间较一致。时间强度曲线示恶性肿瘤组峰值强度明显大于良性肿瘤组（P＜0.05），平均达峰值时间两组无统计学意义（P＞0.05）。常规超声对乳腺癌诊断的敏感性、特异性和准确率分别为70.2%、80.6%、74.4%。超声造影的敏感性、特异性和准确率分别为87.2%、90.3%、88.5%。联合常规超声及超声造影的敏感性、特异性和准确率分别为91.5%、93.5%和92.3%。

结论

超声造影定量分析的造影参数成像图及时间强度曲线分析有助于乳腺肿瘤的诊断。

Objective

To investigate the clinical efficacy of Qontraxt software in contrast-enhanced ultrasound quantitative analysis in the diagnosis of breast tumors.

Methods

Ultrasonography and contrast-enhanced ultrasound（CEUS）were performed in 73 patients with 78 breast tumors.Qontraxt software was used to analyze the parametric imaging color maps of CEUS and the hemodynamic parameters of time intensity curve；each was individually identified using histopathologic diagnosis.

Results

The final histopathologic diagnoses showed malignant in 47 lesions and benign in 31 lesions.The study showed that varied parametric imaging color maps for peak intensity and time to peak were mostly suggestive of malignancy，while the quite uniform peak intensity and time to peak of color maps were the characteristic of benign tumors.The study also revealed malignant lesions presented higher maximum intensity signal than benign ones（P＜0.05）on the time intensity curve.The diagnostic sensitivity，specificity and accuracy of ultrasonography for breast carcinomas was 70.2%，80.6% and 74.4%，respectively.The diagnostic sensitivity，specificity and accuracy of CEUS was 87.2%，90.3% and 88.5%，respectively.The diagnostic sensitivity，specificity and accuracy of the combination of ultrasonography and CEUSwas 91.5%，93.5% and 92.3%，respectively.

Conclusions

Contrast-enhanced ultrasound of parametric imaging color maps and time intensity curve are helpful in diagnosing breast tumors.