目的

探讨前哨淋巴结活检(SLNB)在乳腺癌手术中的临床应用价值。

方法

采用亚甲蓝作为示踪染料对乳腺癌开展SLNB,并且对术中冰冻检查前哨淋巴结(SLN)阴性的病例分组施行部分腋窝淋巴结清扫术(PALND)及常规全腋窝淋巴结清扫(TALND),观察术后并发症、生存率等指标并比较分析。

结果

SLN 检出率97.6%,假阴性率14.3%;接受PALND 组术后并发症发生率明显低于传统的TALND 组,差异有统计学意义(P ＜0.05),而总生存率间的差异无统计学意义(P ＞0.05)。

结论

腋区SLNB 能准确反映乳腺癌腋窝淋巴转移状态,为临床缩小乳腺癌手术范围和减少术后并发症提供重要参考价值。

Objective

To study the clinical value of sentinel lymph node biopsy (SLNB) in breast cancer operation.

Methods

SLNB with methylene blue stain was performed in 42 breast cancer patients.Sentinel lymph node(SLN) negative patients by intraoperative frozen sections were grouped and treated with partial axillary lymph node dissection (PALND) and total axillary lymph node dissection (TALND).Postoperative complications and survival were studied and compared between the two groups.

Results

SLNs were successfully identified in 41 of 42 (97.6%) patients,and the false negative rate was 14.3%. The PALND group had lower incidence of postoperative complications than TALND group, with statistical difference (P ＜0.05). But there was no statistical difference in total survival rate between the two groups (P ＞0. 05).

Conclusion

SLNB can accurately predict the axillary lymph node status of breast cancer, and decrease the extension of surgery and postoperative complications in patients with breast cancer.