The National Comprehensive Cancer Network (NCCN) launched the NCCN Clinical Practice Guideline for Breast Cancer (version 1) on March 20, 2018. This guideline reviews the latest research progress and treatment concepts in the field of breast cancer. On the basis of the previous versions, they update the guidelines for the diagnosis and treatment of breast cancer, which can assist physicians in their clinical practices. This paper interpreted the important changes in the latest version, and discussed its practicability and feasibility in China based on clinical practice, including the TNM staging of breast cancer by American Joint Committee on Cancer (AJCC) (the eighth edition), the principles of breast conserving surgery and pathological evaluation, the recent progress of sentinel lymph node biopsy and new strategy for systematic treatment.