Abstract:
Objective
To observe the correlation between p-AS160(Thr642) and clinical biological parameters in breast cancer.
Methods
Immunohistochemical method was used to detect p-AS160 (Thr642), estrogen receptor(ER), progesterone receptor (PR),P53 and HER-2 levels in tumor tissues of 81 primary breast caner patients. The association between p-AS160 levels and lymph node metastasis, pTNM stage, ER, PR, P53 and HER-2 was analyzed using Chi-square test. The association between p-AS160 (Thr642) levels and the patient’s age and tumor size was analyzed by the Spearman nonparametric test.
Results
p-AS160(Thr642) was inversely correlated with the patient’s age (r=-0.229,P=0.040)and positively correlated with tumor size (r=0.273,P=0.013) and HER-2 (χ2=7.245,P=0.007).
Conclusion
p-AS160 (Thr642) might be useful as a marker and a potential target molecule for breast cancer.
Key words:
breast neoplasms,
phosphorylation,
AS160,
HER-2
Xiao-hua JIANG, Jun LI, Jian-wen SUN, Kong-hua REN, Ge SHANG, Geer Teni, Bei-nian CUI, Long DAI. Correlation of p-AS160 (Thr642) level and clinical biological parameters in breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2012, 06(03): 298-303.