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Chinese Journal of Breast Disease(Electronic Edition) ›› 2012, Vol. 06 ›› Issue (01): 24-30. doi: 10.3877/cma. j. issn.1674-0807.2012.01.004

• Original Article • Previous Articles     Next Articles

Analysis of prognostic factors for synchronous metastatic breast cancer patients treated by surgery

Yun-sheng QIN1, Zi-yi HUANG1,(), Chu-jian HUANG1, Jun-dong WU1, Qiangzhou XU1   

  1. 1.Department of Thoracic Surgery, Cancer Hospital of Shantou University Medical College, Shantou 515031,China
  • Received:2011-11-22 Online:2012-02-01 Published:2024-12-05
  • Contact: Zi-yi HUANG

Abstract:

Objective

To explore the prognostic factors of synchronous metastatic breast cancer (sMBC) patients who underwent surgical treatment.

Methods

The clinical data of 269 sMBC patients admitted into our hospital from January 2000 to December 2010 was collected and analyzed. They included 40 sMBC patients treated by surgery (the surgery group) and 229 sMBC patients receiving non-operative treatment (the control group). Logrank test was used to compare the overall survival (OS) of the patients between the surgery group and the control group, and COX regression model to analyze the prognostic factors of surgical treatment.

Results

The one-year survival of the surgery group and the control group was 83.8% and 71.6%(P=0.018),3-year survival was 47.1% and 23.5%(P=0.000),5-year survival was 22.1% and 11.4% (P = 0.000). All differences were statistically significant. Univariate analysis showed that estrogen receptor-positive and adjuvant chemotherapy were two important factors in improving the prognosis of surgically treated patients. Multivariate analysis showed that adjuvant chemotherapy is an independent factor affecting surgical outcomes.

Conclusion

Surgical treatment for selected sMBC patients can significantly prolong survival time and improve survival rate. Adjuvant chemotherapy is an important factor affecting results of operation.

Key words: breast neoplasms, surgical procedures,operative, prognosis

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