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基因多态性对芳香化酶抑制剂疗效的影响

  • 陈莉 ,
  • 陈雪松
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  • 1. 150081 哈尔滨医科大学附属肿瘤医院乳腺内四科
陈莉,陈雪松.基因多态性对芳香化酶抑制剂疗效的影响[J/CD].中华乳腺病杂志(电子版),2021,15(2):112-116.
通信作者:陈雪松,Email:

收稿日期: 2018-12-06

  网络出版日期: 2021-06-10

Influence of gene polymorphism on efficacy of aromatase inhibitors

  • Li Chen ,
  • Xuesong Chen
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Received date: 2018-12-06

  Online published: 2021-06-10

摘要

芳香化酶抑制剂(AIs)是绝经后激素受体阳性乳腺癌患者的首选内分泌药物。AIs相关基因的单核苷酸多态性(SNP)可能引起个体酶特异性催化活性的改变,从而导致个体间存在差异。相关研究提示,药物代谢酶及其相关基因的SNP是预测乳腺癌患者AIs疗效和不良反应的生物标志物,可指导乳腺癌患者接受更加个体化的内分泌治疗方案。笔者就AIs相关代谢酶、相关转运蛋白及其他相关基因的SNP对药物疗效和不良反应的影响作一介绍。

本文引用格式

陈莉 , 陈雪松 . 基因多态性对芳香化酶抑制剂疗效的影响[J]. 中华乳腺病杂志(电子版), 2021 , 15(02) : 112 -116 . DOI: 10.3877/cma.j.issn.1674-0807.2021.02.009

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