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中华乳腺病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (03) : 187 -189. doi: 10.3877/cma.j.issn.1674-0807.2022.03.010

病例报告

乳头腺瘤一例并文献回顾
刘思雨1, 南丁阿比雅思1, 庞达1,()   
  1. 1. 150000 哈尔滨医科大学附属肿瘤医院乳腺外科
  • 收稿日期:2021-09-21 出版日期:2022-06-01
  • 通信作者: 庞达

Nipple adenoma: one case report and literature review

Siyu Liu1, Abiyasi Nanding1, Da Pang1()   

  • Received:2021-09-21 Published:2022-06-01
  • Corresponding author: Da Pang
引用本文:

刘思雨, 南丁阿比雅思, 庞达. 乳头腺瘤一例并文献回顾[J/OL]. 中华乳腺病杂志(电子版), 2022, 16(03): 187-189.

Siyu Liu, Abiyasi Nanding, Da Pang. Nipple adenoma: one case report and literature review[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2022, 16(03): 187-189.

乳头腺瘤(nipple adenoma)是起源于乳腺输乳管或输乳窦的良性肿瘤,属于导管内乳头状瘤的一种亚型。其发病率不足乳腺良性肿瘤的1%[1],临床表现常为乳头、乳晕区肿块,伴疼痛、血性或浆液性乳头溢液,并可出现类似于乳腺Paget病的皮肤改变[2],如乳头、乳晕区皮肤破溃、结痂等。镜下病理形态多种多样,易与浸润性癌和导管内癌相混淆[3]。组织病理学检查是当前诊断的金标准[2]。哈尔滨医科大学附属肿瘤医院乳腺外科收治了1例18岁乳头腺瘤患者,现将治疗过程报告如下。

图1 左侧乳头腺瘤患者术前乳房外观
图2 左侧乳头腺瘤患者切除左乳头肿块后的乳房外观
图3 左侧乳头腺瘤患者术后病理图(HE ×400) 注:致密的纤维结缔组织内导管呈腺瘤样、乳头状瘤样增生,部分区域上皮细胞增生活跃
图4 左侧乳头腺瘤患者乳头即刻成形术后外观 注:用可吸收线缝合残余左乳头组织
图5 左侧乳头腺瘤患者术后4个月乳头外观 注:左乳头切口愈合后外观满意,血供良好,无缺血、坏死
[1]
邵志敏,沈镇宙,徐兵河. 乳腺肿瘤学[M]. 上海:复旦大学出版社,2013:253.
[2]
Spohn GPRotter SCTozbikian G,et al. Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin:case report,review of the literature,clinical implications,and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin [J]. BMC Dermatol201616(1):4.
[3]
许伟伟,陈世荣,周晓军,等. 乳腺乳头腺瘤4例并文献复习[J]. 临床与实验病理学杂志201935(9):1082-1085.
[4]
Montemarano ADSau PJames WD. Superficial papillary adenomatosis of the nipple: a case report and review of the literature [J]. J Am Acad Dermatol199533(5 Pt 2):871-875.
[5]
Jones DB. Florid papillomatosis of the nipple ducts [J]. Cancer19558(2):315-319.
[6]
Owen JLKrunic AL. Successful treatment of nipple adenoma using mohs micrographic surgery to preserve the nipple-areolar complex [J]. Dermatol Surg202046(1):132-135.
[7]
Shapiro LKarpas CM. Florid papillomatosis of the nipple. First reported case in a male [J]. Am J Clin Pathol196544:155-159.
[8]
Chiorean APintican RMSzep M,et al. Nipple ultrasound: a pictorial essay [J]. Korean J Radiol, 2020, 21(8):955-966.
[9]
丁华野,杨光之. 乳头腺瘤的诊断及鉴别诊断[J]. 临床与实验病理学杂志201026(1):7-9.
[10]
Lyons DWahab RAVijapura C,et al.The nipple-areolar complex: comprehensive imaging review [J]. Clin Radiol, 2021, 76(3):172-184.
[11]
Gray RJPockaj BAKarstaedt PJ.Navigating murky waters: a modern treatment algorithm for nipple discharge [J]. Am J Surg, 2007, 194(6):850-854.
[12]
Tsushimi TEnoki TTakemoto Y,et al. Adenoma of the nipple,focusing on the contrast-enhanced magnetic resonance imaging findings:report of a case [J]. Surg Today, 2011, 41(8):1138-1141.
[13]
Ansari MSTaghizadeh Fazli JEhsani A. Dermoscopy of nipple adenoma [J]. Clin Case Rep20208(12):3254-3256.
[14]
Takashima SFujita YMiyauchi T,et al. Dermoscopic observation in adenoma of the nipple [J]. J dermatol201542(3):341-342.
[15]
Lee CBoughey J. Case report of a synchronous nipple adenoma and breast carcinoma with current multi-modality radiolog ic imaging [J]. Breast J201622(1):105-110.
[16]
Ying SFang HQiao J. Erosive adenomatosis of the nipple: a clinical diagnostic challenge[J]. Clin Cosmet Investig Dermatol202013:587-590.
[17]
孙典典,李靖若,张临风. 乳头部乳头腺瘤一例并文献回顾 [J/CD]. 中华乳腺病杂志(电子版), 2016, 6(10):370-372.
[18]
王晶晶,邰艳红,张慧艳,等. 乳腺乳头腺瘤5例临床病理分析 [J]. 诊断病理学杂志2020, 27(9):609-613.
[19]
Wilsher MJDesai AJPinder SE. Low-grade adenosquamous carcinoma arising in association with a nipple adenoma [J]. Histopathology202076(5):784-787.
[20]
Quintana-Codina MAltemir ASalleras M,et al. Adenoma of the nipple: a mimic of breast malignancy [J]. Dermatol Online J202127(5):14.
[21]
Di Bonito M, Cantile M, Collina F, et al. Adenoma of the nipple:A clinicopathological report of 13 cases [J]. Oncol lett, 2014, 7(6):1839-1842.
[22]
Takazawa YEdamitsu TMaeno K,et al. 5-hydroxymethylcytosine as a putative marker for erosive adenomatosis of the nipple [J]. J Dermatol201643(5):579-580.
[23]
Anja KHélène DPascal VE,et al.Not all cases of mammary paget's disease are cytokeratin-7 positive: a challenging diagnosis! [J]. Int J Surg Pathol, 2021, 29(6):631-634.
[24]
Zeng ZMelamed JSymmans PJ,et al. Benign proliferative nipple duct lesions frequently contain CAM 5.2 and anti-cytokeratin 7 immunoreactive cells in the overlying epidermis [J]. Am J Surg Pathol, 199923(11):1349-1355.
[25]
刘雪青,沈艳玲,杨文圣. 乳腺乳头汗管瘤样肿瘤临床病理分析 [J]. 诊断病理学杂志202027(12):874-876,880.
[26]
Liau JYLee YHTsai JH,et al. Frequent PIK3CA activating mutations in nipple adenomas [J]. Histopathology, 201770(2):195-202.
[27]
Abdulwaasey MTariq MUMinhas K,et al. Invasive breast carcinoma arising in a nipple adenoma after 15 years:report of a rare case and literature review [J]. Cureus202012(6):e8586.
[28]
Barco IVidal MFraile M,et al. Mohs micrographic surgery for treating erosive adenoma of the nipple: a case report and review of the literature [J]. Int J Dermatol, 2017, 56(12):1451-1454.
[29]
Kuflik EG. Erosive adenomatosis of the nipple treated with cryosurgery [J]. J Am Acad Dermatol199838(2 Pt 1):270-271.
[30]
Pasquali PFreites-Martinez AFortuño A. Nipple adenoma: new images and cryosurgery treatment [J]. Breast J, 2016, 22(5):584-585.
[31]
Bae KNShin KKim WI,et al. Cryosurgery as a minimally invasive alternative treatment for a patient with erosive adenomatosis of the nipple [J]. Ann Dermatol202133(2):182-185.
[32]
Zhou XZheng MZou Y,et al. 5-Aminolevulinic acid induced photodynamic therapy(ALA-PDT)for erosive adenomatosis of the nipple: a case report [J]. Photodiagnosis Photodyn Ther202135:102387.
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