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中华乳腺病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (03) : 193 -195. doi: 10.3877/cma.j.issn.1674-0807.2022.03.012

病例报告

淋巴细胞性乳腺炎一例并文献复习
孙珂1, 李嗣杰1, 陈奕蒙1, 毕丽荣1, 范志民1,()   
  1. 1. 130012 长春,吉林大学白求恩第一医院乳腺外科
  • 收稿日期:2019-11-06 出版日期:2022-06-01
  • 通信作者: 范志民

Lymphocytic mastitis: one case report and literature review

Ke Sun1, Sijie Li1, Yimeng Chen1   

  • Received:2019-11-06 Published:2022-06-01
引用本文:

孙珂, 李嗣杰, 陈奕蒙, 毕丽荣, 范志民. 淋巴细胞性乳腺炎一例并文献复习[J]. 中华乳腺病杂志(电子版), 2022, 16(03): 193-195.

Ke Sun, Sijie Li, Yimeng Chen. Lymphocytic mastitis: one case report and literature review[J]. Chinese Journal of Breast Disease(Electronic Edition), 2022, 16(03): 193-195.

淋巴细胞性乳腺炎(lymphocytic mastitis,LM),是一种非常罕见的良性乳腺疾病,又称硬化性淋巴细胞性小叶炎或糖尿病性乳腺病,仅占良性乳腺病变的1%,在1型糖尿病患者中更常见(占13%)[1]。其发病机制不明,可能与自身免疫有关,临床表现与乳腺癌类似,确诊主要依靠组织病理学,文献报道局部切除后容易复发[2]。吉林大学白求恩第一医院收治了1例LM患者,现报道如下。

图1 淋巴细胞性乳腺炎标本的免疫组织化学染色 a图所示CD20阳性B淋巴细胞围绕小叶腺体周边弥漫浸润(EnVision ×200);b图所示CD3阳性T淋巴细胞围绕小叶腺体周边弥漫浸润(EnVision ×200);c图所示CK7阳性的乳腺小叶及小导管腺体减少、萎缩(EnVision ×100);d图所示增生的淋巴组织形成淋巴滤泡(箭头所指处),Bcl-2呈阴性表达(EnVision ×200) 注:CD为白细胞分化抗原;CK为细胞角蛋白
图2 淋巴细胞性乳腺炎的病理表现(HE ×40) 注:乳腺小叶萎缩,小叶、导管及血管周边见大量淋巴细胞及少量浆细胞浸润
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