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中华乳腺病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (01) : 39 -43. doi: 10.3877/cma.j.issn.1674-0807.2022.01.007

综述

来那替尼在人表皮生长因子受体2阳性乳腺癌治疗中的研究进展
洪培甄1, 魏泸懿2, 苟启桁3, 马骥3,()   
  1. 1. 610000 成都,四川大学华西医院肿瘤内科;610000 成都,四川大学华西医院华西公共卫生学院
    2. 610000 成都,四川大学华西医院华西公共卫生学院
    3. 610000 成都,四川大学华西医院肿瘤内科
  • 收稿日期:2021-05-24 出版日期:2022-02-01
  • 通信作者: 马骥
  • 基金资助:
    四川省重点研发资助项目(2020YFS0273); 四川省卫生健康委员会科研资助项目(20PJ008)

Neratinib for treatment of human epidermal growth factor receptor 2 positive breast cancer

Peizhen Hong1, Luyi Wei2, Qiheng Gou3   

  • Received:2021-05-24 Published:2022-02-01
引用本文:

洪培甄, 魏泸懿, 苟启桁, 马骥. 来那替尼在人表皮生长因子受体2阳性乳腺癌治疗中的研究进展[J]. 中华乳腺病杂志(电子版), 2022, 16(01): 39-43.

Peizhen Hong, Luyi Wei, Qiheng Gou. Neratinib for treatment of human epidermal growth factor receptor 2 positive breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2022, 16(01): 39-43.

HER-2阳性乳腺癌有较高的复发和转移风险。曲妥珠单克隆抗体的问世开启了抗HER-2蛋白的靶向治疗,推动了新型抗HER-2药物的开发。在这些药物中,不可逆酪氨酸激酶抑制剂来那替尼能抑制HER-1、HER-2和HER-4相关的酪氨酸激酶,从而有效抑制肿瘤细胞生长,改善乳腺癌患者预后。笔者就来那替尼在HER-2阳性乳腺癌中辅助治疗、新辅助治疗、晚期患者治疗、中枢神经系统转移治疗、HER-2基因突变者治疗以及常见药物不良反应和解决措施这几个方面进行综述。

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