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中华乳腺病杂志(电子版) ›› 2019, Vol. 13 ›› Issue (04) : 242 -244. doi: 10.3877/cma.j.issn.1674-0807.2019.04.010

所属专题: 文献

综述

脂肪组织工程:软组织再生的新策略
谭秋雯1, 吕青1,()   
  1. 1. 610041 成都,四川大学华西医院乳腺外科
  • 收稿日期:2017-04-20 出版日期:2019-08-01
  • 通信作者: 吕青
  • 基金资助:
    中国博士后面上项目(2018M633372); 四川省重点研发项目(2018SZ0052)

Adipose tissue engineering: a new strategy for soft tissue regeneration

Qiuwen Tan1, Qing Lu1()   

  • Received:2017-04-20 Published:2019-08-01
  • Corresponding author: Qing Lu
引用本文:

谭秋雯, 吕青. 脂肪组织工程:软组织再生的新策略[J]. 中华乳腺病杂志(电子版), 2019, 13(04): 242-244.

Qiuwen Tan, Qing Lu. Adipose tissue engineering: a new strategy for soft tissue regeneration[J]. Chinese Journal of Breast Disease(Electronic Edition), 2019, 13(04): 242-244.

软组织缺损是整形外科和乳腺外科常见的问题之一。脂肪组织工程通过种子细胞、生物材料及细胞外微环境构建工程化脂肪组织,是软组织缺损修复有发展潜能的方向之一。选择合适的种子细胞、构建适宜的诱导微环境以及使用组织工程室技术构建带血管蒂组织工程化脂肪是目前常用策略。以干细胞及诱导微环境为核心要素的脂肪组织工程近年来取得了较大的进展,各类生物材料的设计、研发及转化研究将促进脂肪组织工程技术的临床转化。笔者就目前组织工程构建策略的研究进展进行综述。

[1]
National Cancer Institute. Cancer Stat facts: female breast cancer[EB/OL]. [2019-06-27].

URL    
[2]
Jagsi R, Jiang J, Momoh AO, et al. Trends and variation in use of breast reconstruction in patients with breast cancer undergoing mastectomy in the United States [J]. J Clin Oncol, 2014, 32(9): 919-926.
[3]
Yang RL, Newman AS, Lin IC, et al. Trends in immediate breast reconstruction across insurance groups after enactment of breast cancer legislation[J]. Cancer, 2013, 119(13): 2462-2468.
[4]
Kølle SF, Fischer-Nielsen A, Mathiasen AB, et al. Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial[J]. Lancet, 2013,382(9898): 1113-1120.
[5]
Im GI. Bone marrow-derived stem/stromal cells and adipose tissue-derived stem/stromal cells: Their comparative efficacies and synergistic effects[J]. J Biomed Mater Res A, 2017, 105(9):2640-2648.
[6]
Seldin L, Le Guelte A, Macara IG. Epithelial plasticity in the mammary gland[J]. Curr Opin Cell Biol, 2017, 49:59-63.
[7]
Lee E, Piranlioglu R, Wicha MS, et al. Plasticity and potency of mammary stem cell subsets during mammary gland development[J]. Int J Mol Sci, 2019, 20(9):E2357.
[8]
Tan QW, Zhang Y, Luo JC, et al. Hydrogel derived from decellularized porcine adipose tissue as a promising biomaterial for soft tissue augmentation[J]. J Biomed Mater Res A, 2017, 105(6):1756-1764.
[9]
Han TT, Toutounji S, Amsden BG, et al. Adipose-derived stromal cells mediate in vivo adipogenesis, angiogenesis and inflammation in decellularized adipose tissue bioscaffoldss[J]. Biomaterials, 2015, 72:125-137.
[10]
Ridge SM, Sullivan FJ, Glynn SA. Mesenchymal stem cells: key players in cancer progression[J]. Mol Cancer, 2017, 16(1):31.
[11]
Kamat P, Schweizer R, Kaenel P, et al. Human adipose-derived mesenchymal stromal cells may promote breast cancer progression and metastatic spread [J]. Plast Reconstr Surg, 2015, 136(1):76-84.
[12]
Lin W, Huang L, Li Y, et al. Mesenchymal stem cells and cancer: clinical challenges and opportunities[J]. Biomed Res Int, 2019, 2019:2 820 853.
[13]
Zhang C, Yang SJ, Wen Q, et al. Human-derived normal mesenchymal stem/stromal cells in anticancer therapies [J]. J Cancer, 2017, 8(1):85-96.
[14]
Chandler EM, Seo BR, Califano JP, et al. Implanted adipose progenitor cells as physicochemical regulators of breast cancer[J]. Proc Natl Acad Sci U S A, 2012, 109(25): 9786-9791.
[15]
Zhao M, Sachs PC, Wang X, et al. Mesenchymal stem cells in mammary adipose tissue stimulate progression of breast cancer resembling the basal-type[J]. Cancer Biol Ther, 2012, 13(13):782-792.
[16]
Liu X, Hu J, Li Y, et al. Mesenchymal stem cells expressing interleukin-18 inhibit breast cancer in a mouse model[J]. Oncol Lett, 2018,15(5):6265-6274.
[17]
Crapo PM, Gilbert TW, Badylak SF. An overview of tissue and whole organ decellularization processes[J]. Biomaterials, 2011, 32(12): 3233-3243.
[18]
Badylak SF, Taylor D, Uygun K. Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds[J]. Ann Rev Biomed Eng, 2011, 13: 27-53.
[19]
Keane TJ, Deward A, Londono R, et al. Tissue-specific effects of esophageal extracellular matrix[J]. Tissue Eng Part A, 2011, 21(17/18):2293-2300.
[20]
Cortiella J, Niles J, Cantu A, et al. Influence of acellular natural lung matrix on murine embryonic stem cell differentiation and tissue formation[J]. Tissue Eng Part A, 2010, 16(8):2565-2580.
[21]
Flynn LE. The use of decellularized adipose tissue to provide an inductive microenvironment for the adipogenic differentiation of human adipose-derived stem cells[J]. Biomaterials, 2010. 31(17): 4715-4724.
[22]
Poon CJ, Pereira E Cotta MV, Sinha S, et al. Preparation of an adipogenic hydrogel from subcutaneous adipose tissue[J]. Acta Biomater, 2013, 9(3):5609-5620.
[23]
Turner AE, Yu C, Bianco J, et al. The performance of decellularized adipose tissue microcarriers as an inductive substrate for human adipose-derived stem cells[J]. Biomaterials, 2012, 33(18):4490.
[24]
Choi JS, Yang HJ, Kim BS, et al. Fabrication of porous extracellular matrix scaffolds from human adipose tissue[J]. Tissue Eng Part C, 2010, 16(3):387-396.
[25]
Lu Y, Jia C, Bi B, et al. Injectable SVF-loaded porcine extracellular matrix powders for adipose tissue engineering[J]. Rsc Adv, 2016, 6(58):53034-53042.
[26]
Lu Z, Yuan Y, Gao J, et al. Adipose tissue extract promotes adipose tissue regeneration in an adipose tissue engineering chamber model[J]. Cell Tissue Res, 2016, 364(2):289-298.
[27]
Votteler M, Kluger PJ, Walles H, et al. Stem cell microenvironments--unveiling the secret of how stem cell fate is defined [J]. Macromol Biosci, 2010, 10(11):1302-1315.
[28]
Eyckmans J, Boudou T, Yu X, et al. A hitchhiker’s guide to mechanobiology[J]. Dev Cell, 2011, 21(1):35-47.
[29]
Smith Q, Gerecht S. Extracellular matrix regulation of stem cell fate[J]. Curr Stem Cell Rep, 2018, 4(1):13-21.
[30]
Jean C, Gravelle P, Fournie JJ, et al. Influence of stress on extracellular matrix and integrin biology[J]. Oncogene, 2011, 30(24):2697-2706.
[31]
Gobaa S, Hoehnel S, Roccio M, et al. Artificial niche microarrays for probing single stem cell fate in high throughput[J]. Nat Methods, 2011, 8(11):949-955.
[32]
Young DA, Choi YS, Engler AJ, et al. Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue[J]. Biomaterials, 2013, 34(34):8581-8588.
[33]
Chandler EM, Berglund CM, Lee JS, et al. Stiffness of photocrosslinked RGD-alginate gels regulates adipose progenitor cell behavior[J]. Biotechnol Bioeng, 2011, 108(7):1683-1692.
[34]
Rophael JA, Craft RO, Palmer JA, et al. Angiogenic growth factor synergism in a murine tissue engineering model of angiogenesis and adipogenesis[J]. Am J Pathol, 2007, 171(6):2048-2057.
[35]
Jia G, Martinez-Lemus LA, Sowers JR. Interaction of adipogenesis and angiogenesis in dietary-induced obesity[J]. Diabetes, 2015, 64(7):2326-2328.
[36]
Li J, Qiao X, Yu M, et al. Secretory factors from rat adipose tissue explants promote adipogenesis and angiogenesis[J]. Artif Organs, 2014, 38(2):E33-45.
[37]
Zhang Q, Hubenak J, Iyyanki T, et al. Engineering vascularized soft tissue flaps in an animal model using human adipose-derived stem cells and VEGF+PLGA/PEG microspheres on a collagen-chitosan scaffold with a flow-through vascular pedicle[J]. Biomaterials, 2015, 73:198-213.
[38]
Chang KH, Liao HT, Chen JP. Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: in vitro and in vivo studies [J]. Acta Biomater, 2013, 9(11):9012-9026.
[39]
Zhang K, Song L, Wang J, et al. Strategy for constructing vascularized adipose units in poly(l-glutamic acid) hydrogel porous scaffold through inducing in-situ formation of ASCs spheroids[J]. Acta Biomater, 2017, 51:246-257.
[40]
Jeong SH, Han SK, Kim WK. Soft tissue augmentation using in vitro differentiated adipocytes: a clinical pilot study[J]. Dermatol Surg, 2011, 37(6): 760-767.
[41]
Xiao X, Zhou S, Wan J, et al. Pre-shaped large-volume engineered vascularized pedicled adipose flaps in a rabbit model: a two stage tissue engineering chamber-based procedure[J]. J Biomater Tiss Eng, 2017, 7(4):261-268.
[42]
Zhan W, Tan SS, Lu F. Adipose-derived stem cell delivery for adipose tissue engineering: current status and potential applications in a tissue engineering chamber model[J]. Stem Cell Rev, 2016, 12(4): 484-491.
[43]
Wan J, Dong Z, Lei C, et al. Generating an engineered adipose tissue flap using an external suspension device[J]. Plast Reconstr Surg, 2016, 138(1):109-120.
[44]
Findlay MW, Dolderer JH, Trost N, et al. Tissue-engineered breast reconstruction: bridging the gap toward large-volume tissue engineering in humans[J]. Plast Reconstr Surg, 2011, 128(6):1206-1215.
[45]
Walton RL, Beahm EK, Wu L. De novo adipose formation in a vascularized engineered construct [J]. Microsurgery, 2004, 24(5):378-384.
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