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中华乳腺病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (05) : 302 -305. doi: 10.3877/cma.j.issn.1674-0807.2018.05.009

所属专题: 文献

综述

乳腺癌眼部转移的诊治现状
陈畅1, 黄欣1, 茅枫1, 周易冬1, 林燕1, 孙强1,()   
  1. 1. 100730 中国医学科学院北京协和医学院 北京协和医院乳腺外科
  • 收稿日期:2017-04-14 出版日期:2018-10-01
  • 通信作者: 孙强

Diagnosis and treatment of eye metastasis in breast cancer patients

Chang Chen1, Xin Huang1, Feng Mao1   

  • Received:2017-04-14 Published:2018-10-01
引用本文:

陈畅, 黄欣, 茅枫, 周易冬, 林燕, 孙强. 乳腺癌眼部转移的诊治现状[J]. 中华乳腺病杂志(电子版), 2018, 12(05): 302-305.

Chang Chen, Xin Huang, Feng Mao. Diagnosis and treatment of eye metastasis in breast cancer patients[J]. Chinese Journal of Breast Disease(Electronic Edition), 2018, 12(05): 302-305.

随着临床诊疗新技术的发展,越来越多的乳腺癌患者能获得长期生存,乳腺癌眼部转移的病例也增多。当乳腺癌患者发生眼部转移时,容易出现视物模糊、视力下降等症状,从而影响患者的生活质量。目前,对于乳腺癌患者眼部转移的诊断,多以乳腺癌病史结合临床表现和眼部检查(眼底镜、眼部超声、眼底自发荧光检查、眼底血管荧光造影等)为主。治疗方面尚存在争议,一般认为在乳腺癌全身化疗、内分泌治疗以及靶向治疗的基础上,加用局部治疗,如眼部体外放射治疗、质子放射治疗、经瞳孔温热疗法、光动力学疗法、玻璃体内注射贝伐珠单克隆抗体等。笔者从乳腺癌眼部转移的流行病学、临床表现、诊断及治疗等方面进行综述,供临床参考。

[1]
Ban KA,Godellas CV. Godellas. Epidemiology of breast cancer[J]. Surg Oncol Clin N Am, 2014, 23(3): 409-422.
[2]
Nelson CC,Hertzberg BS,Klintworth GK. A histopathologic study of 716 unselected eyes in patients with cancer at the time of death[J]. Am J Ophthalmol, 1983, 95(6): 788-793.
[3]
Kreusel KM,Wiegel T,Stange M, et al. Intraocular metastases of metastatic breast carcinoma in the woman. Incidence, risk factors and therapy[J]. Ophthalmologe, 2000, 97(5): 342-346.
[4]
Marigo FA,Finger PT. Anterior segment tumors: current concepts and innovations[J]. Surv Ophthalmol, 2003, 48(6): 569-593.
[5]
Eliassi-Rad B,Albert DM,Green WR. Frequency of ocular metastases in patients dying of cancer in eye bank populations[J]. Br J Ophthalmol, 1996, 80(2): 125-128.
[6]
Shields CL,Shields JA,Gross NE, et al. Survey of 520 eyes with uveal metastases[J]. Ophthalmology, 1997, 104(8): 1265-1276.
[7]
Georgalas I,Paraskevopoulos T,Koutsandrea C, et al. Ophthalmic metastasis of breast cancer and ocular side effects from breast cancer treatment and management: mini review[J]. Biomed Res Int, 2015, 2015: 574086.
[8]
Eckardt AM,Rana M,Essig H, et al. Orbital metastases as first sign of metastatic spread in breast cancer: case report and review of the literature[J]. Head Neck Oncol, 2011, 3: 37.
[9]
Cohen VM. Ocular metastases[J]. Eye (Lond), 2013, 27: 137-141.
[10]
Wickremasinghe S,Dansingani KK,Tranos P, et al. Ocular presentations of breast cancer[J]. Acta Ophthalmol Scand, 2007, 85(2): 133-142.
[11]
Kreusel KM,Bechrakis NE,Krause L, et al. Incidence and clinical characteristics of symptomatic choroidal metastasis from breast cancer[J]. Acta Ophthalmol Scand, 2007, 85(3): 298-302.
[12]
Olfa G,Riadh H,Sameh T, et al. Breast cancer discovered from choroidal metastasis: Apropos of a case and review of the literature[J]. Can J Ophthalmol, 2009, 44(6): e67.
[13]
Demirci H,Shields CL,Chao AN, et al. Uveal metastasis from breast cancer in 264 patients[J]. Am J Ophthalmol, 2003, 136(2): 264-271.
[14]
Amichetti M,Caffo O,Minatel E, et al. Ocular metastases from breast carcinoma: A multicentric retrospective study[J]. Oncol Rep, 2000, 7(4): 761-765.
[15]
Kuhn M,Shah S,Natasha T, et al. A mouse model of breast cancer metastasis to the choroid of the eye[J]. Clin Exp Metastasis, 2005, 22(8): 685-690.
[16]
Kanthan GL,Jayamohan J,Yip D, et al. Management of metastatic carcinoma of the uveal tract: an evidence-based analysis[J]. Clin Exp Ophthalmol, 2007, 35(6): 553-565.
[17]
Freedman MI,Folk JC. Metastatic tumors to the eye and orbit. Patient survival and clinical characteristics [J]. Arch Ophthalmol, 1987, 105(9): 1215-1219.
[18]
Woog JJ,Chess J,Albert DM, et al. Metastatic carcinoma of the iris simulating iridocyclitis[J]. Br J Ophthalmol, 1984, 68(3): 167-173.
[19]
Shields JA,Shields CL,Singh AD. Metastatic neoplasms in the optic disc: the 1999 Bjerrum Lecture: part 2[J]. Arch Ophthalmol, 2000, 118(2): 217-224.
[20]
Shields CL,Shields JA. Retinal and Choroidal Manifestations of Selected Systemic Diseases[M]. New York: Springer, 2013: 267-282.
[21]
Shields CL,McMahon JF,Atalay HT, et al. Retinal metastasis from systemic cancer in 8 cases[J]. JAMA Ophthalmol, 2014, 132(11): 1303-1308.
[22]
Skalicky SE,Hirst LW,Conway RM. Metastatic breast carcinoma presenting as a conjunctival lesion[J]. Clin Exp Ophthalmol, 2007, 35(8): 767-769.
[23]
Tamai H,Ishida K,Murakami K, et al. Compression neuropathy caused by cancer metastasis to the optic nerve canal[J]. BMC Res Notes, 2013, 6: 546.
[24]
Natesh S,Chin KJ,Finger PT. Choroidal metastases fundus autofluorescence imaging: correlation to clinical, OCT, and fluorescein angiographic findings[J]. Ophthalmic Surg Lasers Imaging, 2010, 41(4): 406-412.
[25]
Ishida T,Ohno-Matsui K,Kaneko Y, et al. Autofluorescence of metastatic choroidal tumor[J]. Int Ophthalmol, 2009, 29(4): 309-313.
[26]
Mewis L,Young SE. Breast carcinoma metastatic to the choroid. Analysis of 67 patients [J]. Ophthalmology, 1982, 89(2): 147-151.
[27]
Eide N,Walaas L. Fine-needle aspiration biopsy and other biopsies in suspected intraocular malignant disease: a review[J]. Acta Ophthalmol, 2009, 87(6): 588-601.
[28]
Yarovoy AA,Bulgakova ES,Shatskikh AV, et al. CORE needle biopsy of orbital tumors[J]. Graefes Arch Clin Exp Ophthalmol, 2013, 251(8): 2057-2061.
[29]
Manquez ME,Shields CL,Karatza EC, et al. Regression of choroidal metastases from breast carcinoma using aromatase inhibitors[J]. Br J Ophthalmol, 2005, 89(6): 776-777.
[30]
Zako M,Takeyama M,Naito E, et al. Choroidal and optic disc metastases from breast cancer and their response to combination pharmacotherapy with tamoxifen, cyclophosphamide hydrate, letrozole, and bevacizumab[J]. J Ocul Pharmacol Ther, 2012, 28(1): 89-93.
[31]
Lim JI,Petrovich Z. Radioactive plaque therapy for metastatic choroidal carcinoma[J]. Ophthalmology, 2000, 107(10): 1927-1931.
[32]
Wiegel T,Bottke D,Kreuseletal KM. External beam radio-herapy of choroidal metastases—final results of a prospective study of the German Cancer Society (ARO 95-08) [J]. Radiother Oncol, 2002, 64(1): 13-18.
[33]
Tsina EK,Lane AM,Zacks DN, et al. Treatment of metastatic tumors of the choroid with proton beam irradiation[J]. Ophthalmology, 2005, 112(2): 337-343.
[34]
Levinger S,Merin S,Seigal R, et al. Laser therapyinthe management of choroidal breast tumor metastases[J]. Ophthalmic Surg Lasers, 2001, 32(4): 294-299.
[35]
Kaliki S,Shields CL,Al-Dahmash SA, et al. Photodynamic therapy for choroidal metastasis in 8 cases[J]. Ophthalmology, 2012, 119(6): 1218-1222.
[36]
Ghodasra DH,Demirci H. Photodynamic therapy for choroidal metastasis[J]. Am J Ophthalmol, 2016, 161: 104-109.
[37]
Fenicia V,Abdolrahimzadeh S,Mannino G, et al. Intravitreal bevacizumab in the successful management of choroidal metastases secondary to lung and breast cancer unresponsive to systemic therapy: a case series[J]. Eye (Lond), 2014, 28(7): 888-891.
[38]
Augustine H,Munro M,Adatia F, et al. Treatment of ocular metastasis with anti-VEGF: a literature review and case report[J]. Can J Ophthalmol, 2014, 49(5): 458-463.
[39]
Maudgil A,Sears KS,Rundle PA, et al. Failure of intravitreal bevacizumab in the treatment of choroidal metastasis[J]. Eye (Lond), 2015, 29(5): 707-711.
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