切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2008, Vol. 02 ›› Issue (05) : 41 -46. doi: 10.3877/cma.j.issn.1674-0807.2008.05.010

综述

乳腺癌中骨桥蛋白表达的研究进展
赵菲1, 姜军1   
  1. 1.400038 重庆,第三军医大学附属西南医院乳腺疾病中心
  • 收稿日期:2007-12-10 出版日期:2008-10-01

Advances in the study of osteopontin expression in breast cancer

Fei ZHAO, Jun JIANG   

  • Received:2007-12-10 Published:2008-10-01
引用本文:

赵菲, 姜军. 乳腺癌中骨桥蛋白表达的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2008, 02(05): 41-46.

Fei ZHAO, Jun JIANG. Advances in the study of osteopontin expression in breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2008, 02(05): 41-46.

[1]
Oldberg A, Franzen A, Heinegard D. Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. Proc Natl Acad Sci USA,1986,83:8819 -8823.
[2]
Mazzali M, Kipari T, Ophascharoensuk V, et al. Osteopontin:a molecule for all seasons. Q J M,2002,95:3 -13.
[3]
Christensen B, Nielsen M S, Haselmann K F, et al. Posttranslationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five Oglycosylation sites and their biological implications. Biochem J,2005,390:285 -292.
[4]
Christensen B, Petersen T E, S rensen E S. Post-translational modification and proteolytic processing of urinary osteopontin.Biochem J,2008,411:53 -61.
[5]
Giancotti F G,Ruoslahti E. Integrin signaling. Science,1999,285:1028 -1032.
[6]
Furger K A, Allan A L, Wilson S M, et al. Beta(3) integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin. Mol Cancer Res,2003,1:810 -819.
[7]
Katagiri Y U,Sleeman J,Fujii H,et al. CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis. Cancer Res,1999,59:219 -226.
[8]
Denhardt D T, Noda M. Osteopontin expression and function:role in bone remodeling. J Cell Biochem Suppl,1998,30 -31:92 -102.
[9]
Hamada Y, Yuki K, Okazaki M, et al. Osteopontin-derived peptide SVVYGLR induces angiogenesis in vivo. Dent Mater J,2004,23:650 -655.
[10]
Ashkar S, Weber G F, Panoutsakopoulou V, et al. Eta-1(osteopontin): an early component of type-1 (cell mediated)immunity. Science,2000,287:860 -864.
[11]
Rittling S R, Novick K E. Osteopontin expression in mammary gland development and tumorigenesis. Cell Growth Differ,1997,8:1061 -1069.
[12]
Nemir M, Bhattacharyya D, Li X, et al. Targeted inhibition of osteopontin expression in the mammary gland causes abnormal morphogenesis and lactation deficiency. J Biol Chem,2000,275:969 -976.
[13]
Brown L F, Berse B, Van de Water L, et al. Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces. Mol Biol Cell,1992,3:1169 -1180.
[14]
Senger D R,Perruzzi C A, Papadopoulos A,et al. Purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin. Biochim Biophys Acta,1989,996:43 -48.
[15]
Nagatomo T, Ohga S, Takada H, et al. Microarray analysis of human milk cells: persistent high expression of osteopontin during the lactation period. Clin Exp Immunol, 2004,138:47 -53.
[16]
El Tanani M K, Campbell F C, Kurisetty V, et al. The regulation and role of osteopontin in malignant transformation and cancer. Cytokine Growth Factor Rev,2006,17:463 -474.
[17]
Shevde L A, Samant R S, Paik J C, et al. Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435. Clin Exp Metastasis, 2006,23:123-133.
[18]
Bellahene A,Castronovo C. Increased expression of osteonectin and osteopontin, two bone matrix proteins in human breast cancer. Am J Pathol,1995,146:95 -100.
[19]
Castronovo V, Bellahcene A. Evidence that breast cancer associated microcalcifications are mineralized malignant cells.Int J Oncol,1998,12:305 -308.
[20]
Oyama T, Sano T, Hikino T, et al. Microcalcifications of breast cancer and atypical cystic lobules associated with infiltration of foam cells expressing osteopontin. Virchows Arch,2002,440:267 -273.
[21]
Tse G M, Tan P H, Cheung H S, et al. Intermediate to highly suspicious calcification in breast lesions: a radio-pathologic correlation. Breast Cancer Res Treat,2007,110:1 -7.
[22]
Tuck A B, O'Malley F P, Singhal H, et al. Osteopontin and p53 expression are associated with tumor progression in a case of synchronous, bilateral, invasive mammary carcinomas. Arch Pathol Lab Med,1997,121:578 -584.
[23]
Kreunin P, Urquidi V, Lubman D M, et al. Identification of metastasis-associated proteins in a human tumor metastasis model using the mass-mapping technique. Proteomics,2004,4:2754 -2765.
[24]
Suzuki M, Mose E, Galloy C, et al. Osteopontin gene expression determines spontaneous metastatic performance of orthotopic human breast cancer xenografts. Am J Pathol,2007,171:682 -692.
[25]
Hullinger T G,Taichman R S,Linseman D A,et al. Secretory products from PC-3 and MCF-7 tumor cell lines upregulate osteopontin in MC3T3-E1 cells. J Cell Biochem, 2000,78:607 -616.
[26]
Schneider D, Liaw L, Daniel C, et al. Inhibition of breast cancer cell adhesion and bone metastasis by the extracellular adherence protein of Staphylococcus aureus. Biochem Biophys Res Commun,2007,357:282 -288.
[27]
Tuck A B, Arsenault D M, O'Malley F P. Osteopontin induces increased invasiveness and plasminogen activator expression of human mammary epithelial cells. Oncogene,1999,18:4237-4246.
[28]
Fisher J L, Field C L, Zhou H, et al. Urokinase plasminogen activator system gene expression is increased in human breast carcinoma and its bone metastases-a comparison of normal breast tissue, non-invasive and invasive carcinoma and osseous metastases. Breast Cancer Res Treat,2000,61:1 -12.
[29]
Das R, Mahabeleshwar G H, Kundu G C. Osteopontin stimulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through phosphatidylinositol 3-kinase/Akt signaling pathways in breast cancer cells. J Biol Chem,2003,278:28 593 -28 606.
[30]
Das R, Philip S, Mahabeleshwar G H, et al. Osteopontin: it's role in regulation of cell motility and nuclear factor kappa Bmediated urokinase type plasminogen activator expression.IUBMB Life,2005,57:441 -447.
[31]
Das R, Mahabeleshwar G H, Kundu G C. Osteopontin induces AP-1-mediated secretion of urokinase-type plasminogen activator through c-Src-dependent epidermal growth factor receptor transactivation in breast cancer cells. J Biol Chem,2004,279:11051 -11064.
[32]
Tuck A B, Hota C, Wilson S M, et al. Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathways.Oncogene,2003,22:1198 -1205.
[33]
El Tanani M, Platt Higgins A, Rudland P S, et al. Ets gene PEA3 cooperates with beta-catenin-Lef-1 and c-Jun in regulation of osteopontin transcription. J Biol Chem,2004,279:20 794 -20 806.
[34]
Mi Z, Guo H, Wai P Y, et al. Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. J Biol Chem,2004,279:46 659 -46 667.
[35]
Adwan H, Bauerle T J, Berger M R. Downregulation of osteopontin and bone sialoprotein II is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells. Cancer Gene Ther2004,11:109 -120.
[36]
Costa C, Soares R, Schmitt F. Angiogenesis: now and then.Acta Pathol Microbiol Immunol Scand,2004,112:402 -412.
[37]
Soares R, Reis Filho J, Gartner F, et al. VEGF, TGFα and estrogen receptors: possible crosstalks and interactions. Am J Pathol,2002,160:381 -382.
[38]
Soares R, Guo S, Russo J, et al. Role of the estrogen antagonist ICI 182 780 in vessel assembly and apoptosis of endothelial cells. Ultrastruct Pathol,2003,27:33 -39.
[39]
Soares R, Balogh G, Guo S, et al. Evidence for the notch signaling pathway on the role of estrogen in angiogenesis. Mol Endocrinol,2004,18:2333 -2343.
[40]
Brooks P Cc, Clark R A, Cheresh D A. Requirement of vascular integrin Ctvrl3 for angiogenesis. Science,1994,264:569 -571.
[41]
Brooks P Cc, Montgomery A M, Rosenfeld M, et al. Integrin ανβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell, 1994,79:1157 -1164.
[42]
Liaw L, Lindner V, Schwartz S M, et al. Osteopontin and β3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro. Circ Res,1995,77:665 -672.
[43]
Senger D R, Ledbetter S R, Claffey K P, et al. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the ανβ3 integrin, osteopontin, and thrombin. Am J Pathol,1996,149:293 -305.
[44]
Malyankar U M, Scatena M, Suchland K L, et al.Osteoprotegerin is an ανβ3-induced, NF-κB-dependent survival factor for endothelial cells. J Biol Chem, 2000,275:20 959 -20 962.
[45]
Chakraborty G, Jain S, Kundu G C. Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms. Cancer Res,2008,68:152 -161.
[46]
Aoudjit F, Vuori K. Integrin signaling inhibits paclitaxelinduced apoptosis in breast cancer cells. Oncogene,2001,20:4995 -5004.
[47]
Zhang Z, Vuori K,Reed J C,et al. The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci USA,1995,92:6161-6165.
[48]
Damiano J S, Cress A E, Hazlehurst L A, et al. Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood,1999,93:1658 -1667.
[49]
Graessmann M, Berg B, Fuchs B, et al. Chemotherapy resistance of mouse WAP-SVT/t breast cancer cells is mediated by osteopontin, inhibiting apoptosis downstream of caspase-3.Oncogene,2007,26:2840 -2850.
[50]
Rudland P S, Platt Higgins A, El Tanani M, et al. Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer. Cancer Res,2002,62:3417 -3427.
[51]
Patani N, Jiang W, Mokbel K. Osteopontin C mRNA expression is associated with a poor clinical outcome in human breast cancer. Int J Cancer,2008,122:2646.
[52]
Senger D R, Perruzzi C A, Gracey C F, et al. Secreted phosphoproteins associated with neoplastic transformation:close homology with plasma proteins cleaved during blood coagulation. Cancer Res,1988,48:5770 -5774.
[53]
Brown L F, Papadopoulos Sergiou A, Berse B, et al.Osteopontin expression and distribution in human carcinomas.Am J Pathol,1994,145:610 -623.
[54]
Bautista D S, Saad Z, Chambers A F, et al. Quantification of osteopontin in human plasma with an ELISA: basal levels in pre- and post-menopausal women. Clin Biochem, 1996,29:231 -239.
[55]
Singhal H, Bautista D S, Tonkin K S, et al. Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival. Clin Cancer Res,1997,3:605 -611.
[56]
Bramwell V H, Doig G S, Tuck A B, et al. Serial plasma osteopontin levels have prognostic value in metastatic breast cancer. Clin Cancer Res,2006,12:3337 -3343.
[57]
Plumer A, Duan H, Subramaniam S, et al. Development of fragment-specific osteopontin antibodies and ELISA for quantification in human metastatic breast cancer. BMC Cancer,2008,8:38 -48.
[1] 洪玮, 叶细容, 刘枝红, 杨银凤, 吕志红. 超声影像组学联合临床病理特征预测乳腺癌新辅助化疗完全病理缓解的价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 571-579.
[2] 刘伟, 牛云峰, 安杰. LINC01232 通过miR-516a-5p/BCL9 轴促进三阴性乳腺癌的恶性进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 330-338.
[3] 杨柳, 宋振川, 王新乐. 乳腺癌改良根治术联合背阔肌复位的临床疗效评估[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(05): 269-273.
[4] 唐丹萍, 王萍, 江孟蝶, 杨晓蓉. 自体脂肪移植在乳腺癌术后乳房重建的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(05): 582-585.
[5] 孙建娜, 孔令军, 任崇禧, 穆坤, 王晓蕊. 266例首诊Ⅳ期乳腺癌手术患者预后分析[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(05): 502-505.
[6] 宋佳, 汪波, 孙凯律, 商江峰, 吴旦平, 肇毅. 吲哚菁绿荧光显影联合亚甲蓝染色在乳腺癌前哨淋巴结活检中的应用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(05): 498-501.
[7] 张钊, 骆成玉, 张树琦, 何平, 李旭斌. 不同术式治疗早期乳腺癌的效果及并发症发生率、复发率比较[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(05): 494-497.
[8] 黄程鑫, 陈莉, 刘伊楚, 王水良, 赖晓凤. OPA1 在乳腺癌组织的表达特征及在ER阳性乳腺癌细胞中的生物学功能研究[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 275-284.
[9] 刘琦, 王守凯, 王帅, 苏雨晴, 马壮, 陈海军, 司丕蕾. 乳腺癌肿瘤内微生物组的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 841-845.
[10] 王帅, 张志远, 苏雨晴, 李雯雯, 王守凯, 刘琦, 李文涛. 孟德尔随机化及其在乳腺癌研究中的应用进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 671-676.
[11] 王誉英, 刘世伟, 王睿, 曾娅玲, 涂禧慧, 张蒲蓉. 老年乳腺癌新辅助治疗病理完全缓解的预测因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 641-646.
[12] 崔军威, 蔡华丽, 胡艺冰, 胡慧. 亚甲蓝联合金属定位夹及定位钩针标记在乳腺癌辅助化疗后评估腋窝转移淋巴结的临床应用价值探究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 625-632.
[13] 张梦婷, 穷拉姆, 色珍, 李逸群, 德庆旺姆. 西藏地区藏族乳腺癌新辅助化疗的真实世界研究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(05): 441-446.
[14] 赵阳, 肖迎聪, 巨艳, 党晓智, 蔡林利, 薛文欣, 李洋, 肖瑶, 郭妤绮, 宋宏萍. 基于自动乳腺超声的列线图模型早期预测HER-2阳性乳腺癌新辅助化疗病理完全缓解的临床价值[J/OL]. 中华临床医师杂志(电子版), 2024, 18(04): 355-362.
[15] 黄宏山, 陈成彩. 经淋巴管超声造影在乳腺癌前哨淋巴结诊断中的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(04): 411-414.
阅读次数
全文


摘要