切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2024, Vol. 18 ›› Issue (05) : 304 -307. doi: 10.3877/cma.j.issn.1674-0807.2024.05.009

综 述

乳腺导管原位癌的浸润转化机制及临床病理特征
于桐1, 孙姗姗1, 刘扬1,()   
  1. 1.150081 哈尔滨医科大学附属肿瘤医院乳腺整形科
  • 收稿日期:2023-11-13 出版日期:2024-10-01
  • 通信作者: 刘扬

Invasion mechanism and clinicopathological features of ductal carcinoma in situ

Tong Yu, Shanshan Sun, Yang Liu()   

  • Received:2023-11-13 Published:2024-10-01
  • Corresponding author: Yang Liu
引用本文:

于桐, 孙姗姗, 刘扬. 乳腺导管原位癌的浸润转化机制及临床病理特征[J]. 中华乳腺病杂志(电子版), 2024, 18(05): 304-307.

Tong Yu, Shanshan Sun, Yang Liu. Invasion mechanism and clinicopathological features of ductal carcinoma in situ[J]. Chinese Journal of Breast Disease(Electronic Edition), 2024, 18(05): 304-307.

乳腺导管原位癌(DCIS) 是一种局限在乳腺导管内的非浸润性乳腺癌,被认为是浸润性导管癌(IDC) 的潜在前体。 近年来,研究发现部分DCIS 病例在未经治疗的情况下会发展成IDC。 此外,IDC 与DCIS 的共存(IDC-DCIS) 在临床上也比较常见,而这2 种病变的共存可能影响患者的临床特征及预后。 IDC 是一种已经突破乳腺导管基底膜并侵入周围组织的乳腺癌,是最常见的乳腺癌类型。与单纯IDC 相比,IDC-DCIS 患者可能在肿瘤分级、生物学特性、治疗响应和远期转移风险等方面表现出差异。 为了深入理解DCIS 如何发展为IDC,以及IDC-DCIS 患者的临床特征和预后影响,笔者对现有文献进行综述,以期更好地理解DCIS 到IDC 的进展机制,为临床治疗提供指导,并帮助预测患者的预后。

[1]
Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2021[J].CA Cancer J Clin, 2021, 71(1):7-33.
[2]
Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263.
[3]
Pang JM, Gorringe KL, Fox SB. Ductal carcinoma in situ - update on risk assessment and management[J]. Histopathology, 2016, 68(1):96-109.
[4]
Lagios MD,Silverstein MJ. Ductal carcinoma in situ:recent history and areas of controversy[J]. Breast J, 2015, 21(1):21-26.
[5]
Ryser MD, Weaver DL, Zhao F, et al. Cancer outcomes in DCIS patients without locoregional treatment[J]. J Natl Cancer Inst, 2019,111(9):952-960.
[6]
Casasent AK, Edgerton M, Navin NE. Genome evolution in ductal carcinoma in situ:invasion of the clones[J]. J Pathol,2017,241(2):208-218.
[7]
Casasent AK, Schalck A, Gao R, et al. Multiclonal invasion in breast tumors identified by topographic single cell sequencing[J]. Cell,2018,172(1-2):205-217.e12.
[8]
Petridis C, Brook MN, Shah V, et al. Genetic predisposition to ductal carcinoma in situ of the breast[J]. Breast Cancer Res,2016,18(1):22.
[9]
Wong H, Lau S, Yau T, et al. Presence of an in situ component is associated with reduced biological aggressiveness of size-matched invasive breast cancer[J]. Br J Cancer, 2010, 102(9):1391-1396.
[10]
Ruszczyk M, Zirpoli G, Kumar S, et al. Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case-control and case-case analyses[J]. Cancer Causes Control, 2016, 27(2):183-198.
[11]
Doebar SC, Sieuwerts AM, de Weerd V, et al. Gene expression differences between ductal carcinoma in situ with and without progression to invasive breast cancer[J]. Am J Pathol,2017,187(7):1648-1655.
[12]
Liu Y,Pandey PR,Sharma S,et al. ID2 and GJB2 promote early-stage breast cancer progression by regulating cancer stemness[J]. Breast Cancer Res Treat, 2019, 175(1):77-90.
[13]
Song G,He L,Yang X,et al. Identification of aberrant gene expression during breast ductal carcinoma in situ progression to invasive ductal carcinoma[J]. J Int Med Res, 2020, 48(1):300060518815364.
[14]
Lin CY, Vennam S, Purington N, et al. Genomic landscape of ductal carcinoma in situ and association with progression[J]. Breast Cancer Res Treat, 2019, 178(2):307-316.
[15]
Johnson KC, Koestler DC, Fleischer T, et al. DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer[J]. Clin Epigenetics, 2015, 7(1):75.
[16]
DeVaux RS, Herschkowitz JI. Beyond DNA: the role of epigenetics in the premalignant progression of breast cancer[J]. J Mammary Gland Biol Neoplasia, 2018, 23(4):223-235.
[17]
Hannafon BN, Ding WQ. miRNAs as biomarkers for predicting the progression of ductal carcinoma in situ [J]. Am J Pathol, 2018,188(3):542-549.
[18]
Bu L, Baba H, Yoshida N, et al. Biological heterogeneity and versatility ofcancer-associatedfibroblastsinthetumor microenvironment[J]. Oncogene, 2019, 38(25):4887-4901.
[19]
Dawoud MM, Jones DT, Chelala C, et al. Expression profile of myoepithelial cells in DCIS: do they change from protective angels to wicked witches? [J]. Appl Immunohistochem Mol Morphol, 2022,30(6):397-409.
[20]
Yeong J, Thike AA, Tan PH, et al. Identifying progression predictors of breast ductal carcinoma in situ[J]. J Clin Pathol, 2017, 70(2):102-108.
[21]
Chen XY, Yeong J, Thike AA, et al. Prognostic role of immune infiltrates in breast ductal carcinoma in situ[J]. Breast Cancer Res Treat, 2019, 177(1):17-27.
[22]
Kim M, Chung YR, Kim HJ, et al. Immune microenvironment in ductal carcinoma in situ: a comparison with invasive carcinoma of the breast[J]. Breast Cancer Res, 2020, 22(1):32.
[23]
Gil Del Alcazar CR, Aleˇckovic′ M, Polyak K. Immune escape during breast tumor progression[J]. Cancer Immunol Res, 2020, 8(4):422-427.
[24]
Niwińska A,Olszewski WP. The role of stromal immune microenvironment in the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer[J]. Breast Cancer Res, 2021, 23(1):118.
[25]
Yu LN,Liu Z,Tian Y,et al. FAP-a and GOLPH3 are hallmarks of DCIS progression to invasive breast cancer[J]. Front Oncol, 2019, 9:1424.
[26]
Elsarraj HS, Hong Y, Limback D, et al. BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression[J]. NPJ Breast Cancer, 2020, 6:12.
[27]
Kim M, Choi HY, Woo JW, et al. Role of CXCL10 in the progression of in situ to invasive carcinoma of the breast[J]. Sci Rep, 2021,11(1):18007.
[28]
Lopez Gordo S, Blanch Falp J, Lopez-Gordo E, et al. Influence of ductal carcinoma in situ on the outcome of invasive breast cancer. A prospective cohort study[J]. Int J Surg, 2019, 63:98-106.
[29]
Goh CW, Wu J, Ding S, et al. Invasive ductal carcinoma with coexisting ductal carcinoma in situ (IDC/DCIS) versus pure invasive ductal carcinoma ( IDC): a comparison of clinicopathological characteristics, molecular subtypes, and clinical outcomes [J]. J Cancer Res Clin Oncol, 2019, 145(7):1877-1886.
[30]
Kole AJ, Park HS, Johnson SB, et al. Overall survival is improved when DCIS accompanies invasive breast cancer[J]. Sci Rep, 2019,9(1):9934.
[31]
Chen H, Bai F, Wang M, et al. The prognostic significance of coexistence ductal carcinoma in situ in invasive ductal breast cancer: a large population-based study and a matched case-control analysis[J].Ann Transl Med, 2019, 7(18):484.
[32]
Dieterich M, Hartwig F,Stubert J,et al. Accompanying DCIS in breast cancer patients with invasive ductal carcinoma is predictive of improved local recurrence-free survival[J]. Breast, 2014, 23(4):346-351.
[33]
Wong H, Lau S, Leung R, et al. Coexisting ductal carcinoma in situ independently predicts lower tumor aggressiveness in node-positive luminal breast cancer[J]. Med Oncol, 2012, 29(3):1536-1542.
[34]
Guan X, Xu G, Shi A, et al. Comparison of clinicopathological characteristics and prognosis among patients with pure invasive ductal carcinoma, invasive ductal carcinoma coexisted with invasive micropapillary carcinoma, and invasive ductal carcinoma coexisted with ductal carcinoma in situ: a retrospective cohort study[J]. Medicine(Baltimore), 2020, 99(50):e23487.
[35]
Carabias-Meseguer P, Zapardiel I, Cusidó-Gimferrer M, et al.Influence of the in situ component in 389 infiltrating ductal breast carcinomas[J]. Breast Cancer, 2013, 20(3):213-217.
[36]
Zeng Y, Gao W,Chen X,et al. Comprehensive analysis of the 21-gene recurrence score in invasive ductal breast carcinoma with or without ductal carcinoma in situ component[J]. Br J Cancer, 2021, 124(5):975-981.
[1] 李洋, 蔡金玉, 党晓智, 常婉英, 巨艳, 高毅, 宋宏萍. 基于深度学习的乳腺超声应变弹性图像生成模型的应用研究[J]. 中华医学超声杂志(电子版), 2024, 21(06): 563-570.
[2] 屈翔宇, 张懿刚, 李浩令, 邱天, 谈燚. USP24及其共表达肿瘤代谢基因在肝细胞癌中的诊断和预后预测作用[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 659-662.
[3] 顾雯, 凌守鑫, 唐海利, 甘雪梅. 两种不同手术入路在甲状腺乳头状癌患者开放性根治性术中的应用比较[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 687-690.
[4] 付成旺, 杨大刚, 王榕, 李福堂. 营养与炎症指标在可切除胰腺癌中的研究进展[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 704-708.
[5] 梁孟杰, 朱欢欢, 王行舟, 江航, 艾世超, 孙锋, 宋鹏, 王萌, 刘颂, 夏雪峰, 杜峻峰, 傅双, 陆晓峰, 沈晓菲, 管文贤. 联合免疫治疗的胃癌转化治疗患者预后及术后并发症分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 619-623.
[6] 张志兆, 王睿, 郜苹苹, 王成方, 王成, 齐晓伟. DNMT3B与乳腺癌预后的关系及其生物学机制[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 624-629.
[7] 王玲艳, 高春晖, 冯雪园, 崔鑫淼, 刘欢, 赵文明, 张金库. 循环肿瘤细胞在乳腺癌新辅助及术后辅助治疗中的应用[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 630-633.
[8] 赵林娟, 吕婕, 王文胜, 马德茂, 侯涛. 超声引导下染色剂标记切缘的梭柱型和圆柱型保乳区段切除术的效果研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(06): 634-637.
[9] 孙建娜, 孔令军, 任崇禧, 穆坤, 王晓蕊. 266例首诊Ⅳ期乳腺癌手术患者预后分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(05): 502-505.
[10] 袁庆港, 刘理想, 张亮, 周世振, 高波, 丁超, 管文贤. 尿素-肌酐比值(UCR)可预测结直肠癌患者术后的长期预后[J]. 中华普外科手术学杂志(电子版), 2024, 18(05): 506-509.
[11] 黄福, 王黔, 金相任, 唐云川. VEGFR2、miR-27a-5p在胃癌组织中的表达与临床病理参数及预后的关系研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(05): 558-561.
[12] 李素娟, 王文玲, 董洪敏, 李小凯, 黄思成, 王刚. 多原发与单原发大肠腺癌的预后分析[J]. 中华消化病与影像杂志(电子版), 2024, 14(05): 407-412.
[13] 郭曌蓉, 王歆光, 刘毅强, 何英剑, 王立泽, 杨飏, 汪星, 曹威, 谷重山, 范铁, 李金锋, 范照青. 不同亚型乳腺叶状肿瘤的临床病理特征及预后危险因素分析[J]. 中华临床医师杂志(电子版), 2024, 18(06): 524-532.
[14] 徐靖亭, 孔璐. PARP抑制剂治疗卵巢癌的耐药机制及应对策略[J]. 中华临床医师杂志(电子版), 2024, 18(06): 584-588.
[15] 闫战涛, 王辉, 周梓迪, 史勇强, 陈铜兵. 胃淋巴上皮瘤样癌三级淋巴结构特征及其与预后的相关性[J]. 中华临床医师杂志(电子版), 2024, 18(05): 455-461.
阅读次数
全文


摘要