切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2025, Vol. 19 ›› Issue (05) : 257 -266. doi: 10.3877/cma.j.issn.1674-0807.2025.05.001

专家论坛

CDK4/6抑制剂在激素受体阳性晚期乳腺癌一线治疗中的挑战及进展后策略
赵诗迪1,2,3, 杨姣1,2,3, 周妍1,2,3, 范园1,2,3, 杨谨1,2,3,()   
  1. 1 710061 西安,西安交通大学第一附属医院肿瘤内科
    2 710061 西安,西安交通大学第一附属医院Ⅰ期临床试验病房
    3 710061 西安,西安交通大学第一附属医院精准医学中心
  • 收稿日期:2025-08-05 出版日期:2025-10-01
  • 通信作者: 杨谨
  • 基金资助:
    北京科创医学发展基金会(KC2023-JX-0082-10)

Challenges and post-progression strategies for CDK4/6 inhibitors in first-line treatment of hormonal receptor positive advanced breast cancer

Shidi Zhao1,2,3, Jiao Yang1,2,3, Yan Zhou1,2,3, Yuan Fan1,2,3, Jin Yang1,2,3,()   

  1. 1 Department of Medical Oncology,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China
    2 Phase I Clinical Trial Ward,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China
    3 Precision Medicine Center,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China
  • Received:2025-08-05 Published:2025-10-01
  • Corresponding author: Jin Yang
引用本文:

赵诗迪, 杨姣, 周妍, 范园, 杨谨. CDK4/6抑制剂在激素受体阳性晚期乳腺癌一线治疗中的挑战及进展后策略[J/OL]. 中华乳腺病杂志(电子版), 2025, 19(05): 257-266.

Shidi Zhao, Jiao Yang, Yan Zhou, Yuan Fan, Jin Yang. Challenges and post-progression strategies for CDK4/6 inhibitors in first-line treatment of hormonal receptor positive advanced breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2025, 19(05): 257-266.

近年来,细胞周期蛋白依赖性激酶4/6(CDK4/6)抑制剂的出现为激素受体阳性(HR+)乳腺癌的治疗带来了重大变革。目前,CDK4/6抑制剂联合内分泌治疗已成为HR+/ HER-2阴性(HER-2-)晚期乳腺癌的标准一线治疗,显著延长了患者的无进展生存期。但是,在一线治疗期间,CDK4/6抑制剂的应用时机、联合伴侣和适用人群及液体活检的应用存在诸多挑战。CDK4/6抑制剂治疗后进展和耐药性的出现也成为临床难题。判断内分泌治疗的敏感性和疾病的进展模式决定患者后续的治疗。对于内分泌治疗依赖的患者,优先进行基因检测(ESR1、PAM通路、BRCA突变)选择靶向抑制剂联合内分泌治疗,或CDK4/6抑制剂跨线治疗;若不适宜进行内分泌治疗,可优选新型抗体药物偶联物(ADC)及化疗。随着更多口服选择性雌激素受体下调剂、PI3K抑制剂及更多靶点的研发,精准化个体治疗将成为趋势。

In recent years,the emergence of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors has revolutionized the treatment of hormone receptor-positive (HR+) breast cancer. Currently,CDK4/6 inhibitors combined with endocrine therapy (ET) have become the standard first-line treatment for HR+/HER-2- advanced breast cancer,significantly extending progression-free survival (PFS). However,during first-line treatment,there are some challenges regarding the timing of CDK4/6 inhibitors administration,combination drugs,eligible patient populations,and the application of liquid biopsy. The progression of disease and emergence of drug resistance following CDK4/6 inhibitor treatment have become clinical challenges. Assessing the sensitivity to endocrine therapy and the pattern of disease progression is crucial for determining subsequent treatment strategies for patients. For patients still dependent on endocrine therapy,priority should be given to genetic testing (ESR1,PAM pathway,BRCA mutation) to select targeted inhibitors combined with ET,or cross-line CDK4/6 inhibitors. For those unsuitable for ET,novel antibody-drug conjugates and chemotherapy are preferred options. With the development of more oral selective estrogen receptor down regulators,PI3K inhibitors and additional targets,precision-based individualized treatment will become the future trend.

图1 HR+/HER-2-乳腺癌晚期一线及进展后治疗现状 注:TFI为无治疗间期;CDK4/6i为CDK4/6抑制剂,AI为芳香化酶抑制剂;FUL为氟维司群;PIK3i为PIK3抑制剂;AKTi为AKT抑制剂;mTORi为mTOR抑制剂;PARPi为聚腺苷二磷酸核糖聚合酶抑制剂;ET为内分泌治疗;HDACi为组蛋白去乙酰化酶抑制剂;T-Dxd为德曲妥珠单克隆抗体;SG为戈沙妥珠单克隆抗体;HER-2为人类表皮生长因子受体2;ESR1为雌激素受体1;PD为疾病进展;HR为激素受体
表1 PI3K/AKT/mTOR通路抑制剂在激素受体阳性的转移性乳腺癌中的应用
药物 研究名称 研究人群 研究方案 中位PFS(月) 中位OS(月)
以PI3K为靶点
Alpelisib SOLAR-12324 AI治疗失败的绝经后HR+/ HER-2-晚期乳腺癌 FUL+Alpelisib vs FUL+安慰剂 11.0 vs 5.7(HR=0.65,95%CI: 0.50~0.85,P=0.000 65) 39.3 vs 31.4(HR=0.86,95%CI: 0.64~1.15,P=0.15)
BYLieve26 CDK4/ 6抑制剂经治伴有PIK3CA突变的HR+/HER-2-晚期乳腺癌 FUL+Alpelisib 8.0(95%CI: 5.6~8.6) 27.3(95%CI: 21.3~32.7)
Inavolisib INAVO12050 有PIK3CA突变的初治HR+/HER-2-晚期乳腺癌 哌柏西利+FUL+ Inavolisib vs 哌柏西利+FUL+安慰剂 17.2 vs 7.3(HR=0.42,95%CI: 0.32~0.55) 34.0 vs 27.0 (HR=0.67,95%CI: 0.48~0.94,P=0.019)
RLY-2608 ReDiscover51 既往接受过治疗的伴有PIK3CA突变的HR+/HER-2-晚期乳腺癌 RLY-2608+FUL 9.2(95%CI: 5.8~18.4)a; 11.4(95%CI: 7.2~NR)b
以AKT为靶点
Capivasertib CAPItello-29130 AI治疗失败的绝经后HR+/ HER-2-晚期乳腺癌 FUL+Capivasertib vs FUL+安慰剂 7.2 vs 3.6(HR=0.60,95%CI: 0.51~0.71,P<0.001)
FAKTION52 AI治疗失败的绝经后HR+/ HER-2-晚期乳腺癌 FUL+Capivasertib vs FUL+安慰剂 10.3 vs 4.8(HR=0.58,P=0.004) 29.3 vs 23.4(HR=0.66,P=0.035)
Ipatasertib FINER32 一线CDK4/6抑制剂+AI治疗进展后的ER+/HER-2-转移性乳腺癌患者 FUL+Ipatasertib vs FUL+安慰剂 5.32 vs 1.94(HR=0.61,P=0.000 7)
以mTOR为靶点
依维莫司 BOLERO-253-54 AI治疗后疾病进展的患者 依西美坦+依维莫司 vs依西美坦+安慰剂 7.8 vs 3.2(HR=0.45,95%CI:0.38~0.54,P<0.000 1) 31.0 vs 26.6(HR=0.89,95%CI: 0.73~1.10,P=0.142 6)
PrE010233 AI治疗后疾病进展的患者 FUL+依维莫司 vs FUL+安慰剂 10.3 vs 5.1(HR=0.61,95%CI: 0.40~0.92,P=0.02) 31.4 vs 28.3(HR=1.31,95%CI:0.72~2.38,P=0.37)
以PI3K及mTOR为靶点
Gedatolisib VIKTORIA-155 接受CDK4/6抑制剂和AI治疗后进展的HR+/HER-2-/PIK3CA野生型局部晚期或转移性乳腺癌患者 Gedatolisib联合FUL(±哌柏西利) vs FUL单药 三联方案 vs双联方案 vs FUL单药: 9.3 vs 7.4 vs 2.0
[1]
Rugo HSFinn RSDiéras V, et al. Palbociclib plus letrozole as first-line therapy in estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with extended follow-up [J]. Breast Cancer Res Treat2019174(3): 719-729.
[2]
Finn RSMartin MRugo HS, et al. Palbociclib and letrozole in advanced breast cancer [J]. N Engl J Med2016375(20): 1925-1936.
[3]
Goetz MPToi MHuober J, et al. Abemaciclib plus a nonsteroidal aromatase inhibitor as initial therapy for HR+, HER2- advanced breast cancer: Final overall survival results of MONARCH 3 [J]. Ann Oncol202435(8): 718-727.
[4]
Hortobagyi GNStemmer SMBurris HA, et al. Overall survival with ribociclib plus letrozole in advanced breast cancer [J]. N Engl J Med2022386(10): 942-950.
[5]
Xu BZhang PZhang QY. Dalpiciclib versus placebo in combination with letrozole or anastrozole as first-line treatment for women with HR+/HER2- advanced breast cancer: Prespecified final analysis of progression-free survival of the phase 3 DAWNA-2 trial [J]. Clin Cancer Res202531(12 Suppl): PS2-01.
[6]
Lu YSMahidin EAzim H, et al. Final results of right choice: ribociclib plus endocrine therapy versus combination chemotherapy in premenopausal women with clinically aggressive hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer [J]. J Clin Oncol202442(23): 2812-2821.
[7]
De La Haba Rodriguez JCortés JDi Cosimo S, et al. Randomized phase II study of abemaciclib plus endocrine therapy (et) with or without a short course of induction paclitaxel in patients (pts) with previously untreated HR-positive/HER2-negative advanced breast cancer (HR+/HER2- ABC) with aggressive disease criteria [J]. Ann Oncol202435: S1215-S1216.
[8]
Loibl SThill MRey J, et al. Primary results of the randomised phase III trial comparing first-line et plus palbociclib vs standard mono-chemotherapy in women with high risk HER2-/HR+ metastatic breast cancer and indication for chemotherapy - PADMA study [J]. Clin Cancer Res202531(12 Suppl): LB1-03.
[9]
Tolaney SMSahebjam SLe Rhun E, et al. A phase II study of abemaciclib in patients with brain metastases secondary to hormone receptor-positive breast cancer [J]. Clin Cancer Res202026(20): 5310-5319.
[10]
Cottu PRing AAbdel-Razeq H, et al. Ribociclib plus letrozole in subgroups of special clinical interest with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: subgroup analysis of the phase IIIb compleement-1 trial [J]. Breast202262:75-83.
[11]
Zhao SZhang HYang N, et al. A narrative review about CDK4/6 inhibitors in the setting of drug resistance: updates on biomarkers and therapeutic strategies in breast cancer [J]. Transl Cancer Res202312(6): 1617-1634.
[12]
Cardoso FPaluch-Shimon SSenkus E, et al. 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) [J]. Ann Oncol202031(12): 1623-1649.
[13]
Li ZHu MPang F, et al. A comprehensive analysis of dysregulation in the PTEN/PI3K/AKT pathway in breast cancer among the Chinese population [J]. Clin Cancer Res202531(12 Suppl): P3-10-13.
[14]
Cai ZWang JLi Y, et al. Overexpressed cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors [J]. Sci China Life Sci202366(1): 94-109.
[15]
Bidard FCHardy-Bessard ACDalenc F, et al. Switch to fulvestrant and Palbociclib versus no switch in advanced breast cancer with rising ESR1 mutation during aromatase inhibitor and palbociclib therapy (PADA-1): a randomised, open-label, multicentre, phase 3 trial [J]. Lancet Oncol202223(11): 1367-1377.
[16]
Sonke GSVan Ommen-Nijhof AWortelboer N, et al. Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer [J]. Nature2024636(8042): 474-480.
[17]
Jongbloed EMWortelboer NDe Weerd V, et al. Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer: circulating tumor DNA analysis of a randomized phase 3 trial[EB/OL]. [2025-07-20].
[18]
Yang JZhao BLing X, et al. Palbociclib plus endocrine therapy in hormone receptor-positive and HER2 negative metastatic breast cancer: a multicenter real-world study in the northwest of china [J]. BMC Cancer202323(1): 103.
[19]
Bidard FCKaklamani VGNeven P, et al. Elacestrant (oral selective estrogen receptor degrader) versus standard endocrine therapy for estrogen receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: results from the randomized phase Ⅲ EMERALD trial [J]. J Clin Oncol202240(28): 3246-3256.
[20]
Bardia ACortés JBidard FC, et al. Elacestrant in ER+, HER2- metastatic breast cancer with esr1-mutated tumors: subgroup analyses from the phase Ⅲ emerald trial by prior duration of endocrine therapy plus CDK4/6 inhibitor and in clinical subgroups [J]. Clin Cancer Res202430(19): 4299-4309.
[21]
Jhaveri KLNeven PCasalnuovo ML, et al. Imlunestrant with or without abemaciclib in advanced breast cancer [J]. N Engl J Med2025392(12): 1189-1202.
[22]
Jhaveri KLLim EJeselsohn R, et al. Imlunestrant, an oral selective estrogen receptor degrader, as monotherapy and in combination with targeted therapy in estrogen receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: phase Ia/Ib EMBER study [J]. J Clin Oncol202442(35): 4173-4186.
[23]
André FCiruelos ERubovszky G, et al. Alpelisib for PI3KCA-mutated, hormone receptor-positive advanced breast cancer [J]. N Engl J Med2019380(20): 1929-1940.
[24]
André FCiruelos EMJuric D, et al. Alpelisib plus fulvestrant for PI3KCA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: final overall survival results from solar-1 [J]. Ann Oncol202132(2): 208-217.
[25]
Narayan PProwell TMGao JJ, et al. Fda approval summary: alpelisib plus fulvestrant for patients with HR-positive, HER2-negative, PIK3CA-mutated, advanced or metastatic breast cancer [J]. Clin Cancer Res202127(7): 1842-1849.
[26]
Rugo HSLerebours FCiruelos E, et al. Alpelisib plus fulvestrant in PI3KCA-mutated, hormone receptor-positive advanced breast cancer after a CDK4/6 inhibitor (bylieve): one cohort of a phase 2, multicentre, open-label, non-comparative study [J]. Lancet Oncol202425(12): e629-e638.
[27]
Turner NCIm SASaura C, et al. Inavolisib-based therapy in PI3KCA-mutated advanced breast cancer [J]. N Engl J Med2024391(17): 1584-1596.
[28]
Turner NCIm SASaura C, et al. Inavo120: phase Ⅲ trial final overall survival (OS) analysis of first-line inavolisib (INAVO)/placebo (PBO) + palbociclib (PALBO) + fulvestrant (FULV) in patients (pts) with PI3KCA-mutated, hormone receptor-positive (HR+), HER2-negative (HER2–), endocrine-resistant advanced breast cancer (aBC) [J]. J Clin Oncol202543(16 Suppl): 1003.
[29]
Loi SMartin HOliveira M, et al. Abstract p4-07-23: Preliminary safety in the inavolisib + fulvestrant + ribociclib/abemaciclib arms of morpheus-pan breast cancer: a phase 1b/2 study of efficacy & safety of multiple treatment combinations in patients with metastatic/locally advanced breast cancer [J]. Clin Cancer Res202531(12 Suppl): P4-07-23-P04-07-23.
[30]
Turner NCOliveira MHowell SJ, et al. Capivasertib in hormone receptor-positive advanced breast cancer [J]. N Engl J Med2023388(22): 2058-2070.
[31]
Teysir JLloyd MRAlkassis S, et al. After a CDK4/6 inhibitor: state of the art in hormone receptor–positive metastatic breast cancer [J]. Am Soc Clin Oncol Educ Book202545(3): e473372.
[32]
Chia SKLRedfern ADAyoub JPM, et al. A double-blind placebo controlled randomized phase iii trial of fulvestrant and ipatasertib as treatment for advanced HER2-negative and estrogen receptor positive (ER+) breast cancer following progression on first line CDK4/6 inhibitor and aromatase inhibitor: the CCTG/BCT MA. 40/FINER study (NCT04650581) [J]. J Clin Oncol202543(17 Suppl): LBA1005-LBA1005.
[33]
Kornblum NZhao FManola J, et al. Randomized phase II trial of fulvestrant plus everolimus or placebo in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer resistant to aromatase inhibitor therapy: results of PrE0102 [J]. J Clin Oncol201836(16): 1556-1563.
[34]
Baselga JCampone MPiccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer [J]. N Engl J Med2012366(6): 520-529.
[35]
Vasseur ACabel LHego C, et al. Fulvestrant and everolimus efficacy after CDK4/6 inhibitor: a prospective study with circulating tumor DNA analysis [J]. Oncogene202443(16): 1214-1222.
[36]
Princic NAizer ATang DH, et al. Predictors of systemic therapy sequences following a CDK 4/6 inhibitor-based regimen in post-menopausal women with hormone receptor positive, HEGFR-2 negative metastatic breast cancer [J]. Curr Med Res Opin201935(1): 73-80.
[37]
Tolaney SMToi MNeven P, et al. Clinical significance of PI3KCA and ESR1 mutations in circulating tumor DNA: analysis from the Monarch 2 study of abemaciclib plus fulvestrant [J]. Clin Cancer Res202228(8): 1500-1506.
[38]
Dempsey NBhatt PLewis C, et al. Co-occurrence of ESR1 and PIK3CA mutations in HR+/HER2- metastatic breast cancer: incidence and outcomes with targeted therapy [J]. J Clin Oncol202442(16 Suppl): e13097.
[39]
Turner NRugo HSCiruelos EM, et al. Impact of ESR1 mutations on endocrine therapy (ET) plus alpelisib benefit in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), PIK3CA-mutated, advanced breast cancer (ABC) who progressed on or after prior cyclin-dependent kinase inhibitor (CDK4/6i) therapy in the BYLieve trial [J]. Cancer Res202282(4 Suppl): PD15-01-PD15-01.
[40]
Triantafyllidou OVlachos ISApostolou P, et al. Epidemiological and clinicopathological characteristics of BRCA-positive and BRCA-negative breast cancer patients in greece [J]. J BUON201520(4): 978-984.
[41]
Armstrong NRyder SForbes C, et al. A systematic review of the international prevalence of BRCA mutation in breast cancer [J]. Clin Epidemiol201911: 543-561.
[42]
Alter BPBest AF. Frequency of heterozygous germline pathogenic variants in genes for fanconi anemia in patients with non-BRCA1/BRCA2 breast cancer: a meta-analysis [J]. Breast Cancer Res Treat2020182(2): 465-476.
[43]
Casadei SNorquist BMWalsh T, et al. Contribution of inherited mutations in the BRCA2-interacting protein palb2 to familial breast cancer [J]. Cancer Res201171(6): 2222-2229.
[44]
Robson METung NConte P, et al. Olympiad final overall survival and tolerability results: olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer [J]. Ann Oncol201930(4): 558-566.
[45]
Litton JKHurvitz SAMina LA, et al. Talazoparib versus chemotherapy in patients with germline BRCA1/2-mutated HER2-negative advanced breast cancer: final overall survival results from the embraca trial [J]. Ann Oncol202031(11): 1526-1535.
[46]
Robson MIm SASenkus E, et al. Olaparib for metastatic breast cancer in patients with a germline BRCA mutation [J]. N Engl J Med2017377(6): 523-533.
[47]
Litton JKRugo HSEttl J, et al. Talazoparib in patients with advanced breast cancer and a germline BRCA mutation [J]. N Engl J Med2018379(8): 753-763.
[48]
Rugo HSRumble RBMacrae E, et al. Endocrine therapy for hormone receptor-positive metastatic breast cancer: American Society of Clinical Oncology guideline [J]. J Clin Oncol201634(25): 3069-3103.
[49]
Cardoso FPaluch-Shimon SSchumacher-Wulf E, et al. 6th and 7th International consensus guidelines for the management of advanced breast cancer (ABC guidelines 6 and 7) [J]. Breast202476:103756.
[50]
Turner NCIm SASaura C, et al. INAVO120: Phase III trial final overall survival (OS) analysis of first-line inavolisib (INAVO)/placebo (PBO) + palbociclib (PALBO) + fulvestrant (FULV) in patients (pts) with PIK3CA-mutated, hormone receptor-positive (HR+), HER2-negative (HER2–), endocrine-resistant advanced breast cancer (aBC). [J]. J Clin Oncol202543(16 Suppl): 1003.
[51]
Sammons SLManich CSItaliano A, et al. Updated efficacy of mutant-selective PI3Kα inhibitor rly-2608 in combination with fulvestrant in patients with PI3KCA-mutant HR+HER2- advanced breast cancer: Rediscover trial [J]. J Clin Oncol202543(16 Suppl): 1086-1086.
[52]
Jones RHCasbard ACarucci M, et al. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial [J]. Lancet Oncol202021(3): 345-357.
[53]
Piccart MHortobagyi GNCampone M, et al. Everolimus plus exemestane for hormone-receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: overall survival results from BOLERO-2 [J]. Ann Oncol201425(12): 2357-2362.
[54]
Yardley DANoguchi SPritchard KI, et al. Everolimus plus exemestane in postmenopausal patients with HR(+) breast cancer: BOLERO-2 final progression-free survival analysis [J]. Adv Ther201330(10): 870-884.
[55]
Layman RMHan HSRugo HS, et al. Overall survival in patients with hormone receptor-positive, HER2-negative advanced breast cancer treated in a phase 1b trial evaluating gedatolisib in combination with palbociclib and endocrine therapy [J]. Lancet Oncol202526(7): e332-e333.
[56]
Kalinsky KAccordino MKChiuzan C, et al. Randomized phase II trial of endocrine therapy with or without ribociclib after progression on cyclin-dependent kinase 4/6 inhibition in hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer: maintain trial [J]. J Clin Oncol202341(24): 4004-4013.
[57]
Kalinsky KBianchini GHamilton EP, et al. Abemaciclib plus fulvestrant vs fulvestrant alone for HR+, HER2- advanced breast cancer following progression on a prior CDK4/6 inhibitor plus endocrine therapy: Primary outcome of the phase 3 postmonarch trial [J]. J Clin Oncol202442(17 Suppl): LBA1001.
[58]
Mayer ELRen YWagle N, et al. Pace: a randomized phase II study of fulvestrant, palbociclib, and avelumab after progression on cyclin-dependent kinase 4/6 inhibitor and aromatase inhibitor for hormone receptor-positive/human epidermal growth factor receptor-negative metastatic breast cancer [J]. J Clin Oncol202442(17): 2050-2060.
[59]
Llombart-Cussac AHarper-Wynne CPerelló A, et al. Second-line endocrine therapy with or without palbociclib rechallenge in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: PALMIRA trial [J]. J Clin Oncol202543(18): 2084-2093.
[60]
Robert NJDiéras VGlaspy J, et al. Ribbon-1: Randomized, double-blind, placebo-controlled, phase iii trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2–negative, locally recurrent or metastatic breast cancer [J]. J Clin Oncol201129(10): 1252-1260.
[61]
O'shaughnessy JPiccart-Gebhart MJSchwartzberg LS, et al. Contessa: A multinational, multicenter, randomized, phase 3 registration study of tesetaxel in patients (pts) with HER2-, hormone receptor + (HR+) locally advanced or metastatic breast cancer (mBC) [J]. J Clin Oncol201836(15 Suppl): TPS1106.
[62]
O'shaughnessy JMcintyre KWilks S, et al. Efficacy and safety of weekly paclitaxel with or without oral alisertib in patients with metastatic breast cancer: A randomized clinical trial [J]. JAMA Network Open20214(4): e214103.
[63]
Curigliano GCiruelos EKalinsky K, et al. Short-term risk of recurrence in patients (pts) with HR+/HER2− early breast cancer (eBC) treated with endocrine therapy (et) in randomized clinical trials (rcts): A meta-analysis [J]. J Clin Oncol202442(16 Suppl): 541.
[64]
Modi SPark HMurthy RK, et al. Antitumor activity and safety of trastuzumab deruxtecan in patients with HER2-low–expressing advanced breast cancer: results from a phase Ib study [J]. J Clin Oncol202038(17): 1887-1896.
[65]
Modi SJacot WYamashita T, et al. Trastuzumab deruxtecan in previously treated HER2-low advanced breast cancer [J]. N Engl J Med2022387(1): 9-20.
[66]
Bardia AHu XDent R, et al. Trastuzumab deruxtecan after endocrine therapy in metastatic breast cancer [J]. N Engl J Med2024391(22): 2110-2122.
[67]
Liao SWang BZeng R, et al. Recent advances in trophoblast cell-surface antigen 2 targeted therapy for solid tumors [J]. Drug Dev Res202182(8): 1096-1110.
[68]
Ambrogi FFornili MBoracchi P, et al. Trop-2 is a determinant of breast cancer survival [J]. PLoS ONE20149(5): e96993.
[69]
Rugo HSBardia AMarmé F, et al. Sacituzumab govitecan in hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer [J]. J Clin Oncol202240(29): 3365-3376.
[70]
Rugo HSBardia AMarmé F, et al. Overall survival with sacituzumab govitecan in hormone receptor-positive and human epidermal growth factor receptor 2-negative metastatic breast cancer (tropics-02): a randomised, open-label, multicentre, phase 3 trial [J]. Lancet2023402(10411): 1423-1433.
[71]
Xu BWang SYan M, et al. Sacituzumab govitecan in HR(+)HER2(-) metastatic breast cancer: the randomized phase 3 ever-132-002 trial [J]. Nat Med202430(12): 3709-3716.
[72]
Rugo HCortés JCurigliano G, et al. Ascent-07: a phase 3, randomized, open-label study of sacituzumab govitecan versus treatment of physician's choice in patients with HR+/HER2– inoperable, locally advanced, or metastatic breast cancer post-endocrine therapy [J]. Cancer Res202484(9 Suppl): PO1-05-09-PO01-05-09.
[73]
Nakada TMasuda TNaito H, et al. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads [J]. Bioorg Med Chem Lett201626(6): 1542-1545.
[74]
Bardia AJhaveri KIm SA, et al. Datopotamab deruxtecan versus chemotherapy in previously treated inoperable/metastatic hormone receptor-positive human epidermal growth factor receptor 2-negative breast cancer: primary results from TROPION-breast01 [J]. J Clin Oncol202543(3): 285-296.
[75]
Royce M, Shah M, Zhang L, et al. FDA Approval Summary: Datopotamab deruxtecan-dlnk for treatment of patients with unresectable or metastatic, HR-positive, HER2-negative breast cancer [J]. Clin Cancer Res, 2025, 31(21):4405-4411.
[76]
Li YLi WGong C, et al. A multicenter analysis of treatment patterns and clinical outcomes of subsequent therapies after progression on palbociclib in HR+/HER2- metastatic breast cancer [J]. Ther Adv Med Oncol202113: 17588359211022890.
[77]
Mougalian SSFeinberg BAWang E, et al. Observational study of clinical outcomes of eribulin mesylate in metastatic breast cancer after cyclin-dependent kinase 4/6 inhibitor therapy [J]. Future Oncol201915(34): 3935-3944.
[78]
Xu BSun TZhang Q, et al. Efficacy of utidelone plus capecitabine versus capecitabine for heavily pretreated, anthracycline- and taxane-refractory metastatic breast cancer: final analysis of overall survival in a phase Ⅲ randomised controlled trial [J]. Ann Oncol202132(2): 218-228.
[1] 孙圣梅, 习一清, 安宁. 人表皮生长因子受体2阳性型乳腺癌新辅助治疗响应的基因预测模型[J/OL]. 中华普通外科学文献(电子版), 2025, 19(05): 332-339.
[2] 阮希伦, 单臻, 范远键, 林颖, 王深明, 龙健婷, 徐向东. 一项妊娠相关性乳腺癌病理学特征、治疗方案及预后信息的回顾性研究[J/OL]. 中华普通外科学文献(电子版), 2025, 19(05): 340-344.
[3] 严孟欣, 朱星瑀, 陈翔. 真空辅助微创切除术治疗乳腺良性分叶状肿瘤的安全性评估:基于倾向性评分匹配[J/OL]. 中华普通外科学文献(电子版), 2025, 19(04): 269-273.
[4] 王达, 朱建敏. 血小板/淋巴细胞计数比值对乳腺癌新辅助化疗疗效的预测效能[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(06): 650-653.
[5] 马超, 王传嘉, 张武坊. 经腋窝入路单孔腔镜保乳术与传统开放手术治疗早期乳腺癌的对比研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(06): 674-677.
[6] 孟庆杰, 印玉龙, 韩晓刚, 张浩萌, 江思源, 刘向华, 吕勇刚, 刘曌宇. 保留皮肤乳房切除+乳腺重建术治疗早期乳腺癌的近期随访研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(06): 646-649.
[7] 刘小娜, 史博慧, 马晓霞, 陈瑶, 郝娜. 乳腺癌不同手术方式对术后并发症及康复影响的对比观察[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(05): 551-554.
[8] 郭雯, 任谊, 魏庆忠. 改良VSD装置在乳腺癌改良根治术后腋窝引流中的临床应用价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(05): 555-558.
[9] 张克俭, 赵建红, 尚培中, 张克勤, 张少斌, 王铁山. 乳腺癌肺转移术后化疗并发骨髓增生异常和Sweet综合征一例报道[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(04): 471-472.
[10] 廖志成, 朱黎, 曾志宇. 广东省医学会泌尿外科疑难病例多学科会诊(第27期)——晚期肾癌[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(05): 669-676.
[11] 薛国强, 赵立明, 刘学军, 任玉林, 晏发隆, 杨晨, 杨嘉祺, 王永翔, 康印东. 甘草酸对尿源性脓毒症相关急性肾损伤的作用机制研究[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(04): 498-507.
[12] 张辉, 林金铭, 郭高伟, 李鑫基, 张伟, 黄沛东, 郑长征, 陈晓生, 卢勇. 广东省医学会泌尿外科疑难病例多学科会诊(第17期)——右肾巨大肿瘤并腔静脉癌栓和髂血管血栓[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(04): 532-538.
[13] 刘丽辉, 白玉新, 张进, 冯巍, 黄琰琰, 邹梦斯, 刘彩红. 血清生物标志物联合检测对支气管哮喘患儿生物靶向治疗效果的预测意义[J/OL]. 中华肺部疾病杂志(电子版), 2025, 18(05): 796-801.
[14] 胡铭语, 李敬东, 肖雨竹, 黄杰. 初始不可切除肝癌患者转化治疗序贯手术的临床疗效分析[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(05): 754-760.
[15] 李鑫睿, 江明珠, 时萍, 牟洪宾. 线粒体稳态在慢性肾脏病发病机制中的作用研究进展[J/OL]. 中华肾病研究电子杂志, 2025, 14(05): 276-287.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?