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中华乳腺病杂志(电子版) ›› 2025, Vol. 19 ›› Issue (04) : 193 -197. doi: 10.3877/cma.j.issn.1674-0807.2025.04.001

指南与共识

乳腺癌新辅助免疫治疗专家共识(2025年版)
《乳腺癌新辅助免疫治疗专家共识》专家组   
  • 收稿日期:2025-05-07 出版日期:2025-08-01
  • 基金资助:
    国家自然科学基金资助项目(82373281)

Expert consensus on neoadjuvant immunotherapy for breast cancer (2025 edition)

Expert group for expert consensus on neoadjuvant immunotherapy for breast cancer   

  • Received:2025-05-07 Published:2025-08-01
引用本文:

《乳腺癌新辅助免疫治疗专家共识》专家组. 乳腺癌新辅助免疫治疗专家共识(2025年版)[J/OL]. 中华乳腺病杂志(电子版), 2025, 19(04): 193-197.

Expert group for expert consensus on neoadjuvant immunotherapy for breast cancer. Expert consensus on neoadjuvant immunotherapy for breast cancer (2025 edition)[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2025, 19(04): 193-197.

随着免疫检查点抑制剂在乳腺癌新辅助治疗中的应用,乳腺癌辅助免疫治疗展现出重要潜力。本共识由多学科专家组基于现有循证医学证据和临床实践,深入讨论乳腺癌辅助免疫治疗策略并形成共识意见。共识提出免疫治疗前置可提高乳腺癌病理完全缓解率并具有远期生存获益潜力,三阴性乳腺癌及激素受体阳性/HER-2阴性乳腺癌是接受新辅助免疫治疗的优选人群,对药物配伍及后续治疗方案给出相应对策;另外,专家组认可肿瘤浸润淋巴细胞表达能较好地提示新辅助免疫治疗疗效,新辅助免疫治疗联合靶向治疗对三阴性乳腺癌和 HER-2阳性乳腺癌显示出初步前景,但需进一步验证。

With the significant potential of immune checkpoint inhibitors in neoadjuvant treatment for breast cancer,a multidisciplinary expert group was formed to develop this consensus based on the existing evidence-based medical evidences and clinical practice through in-depth discussions. The consensus suggests that pre-positioning of immunotherapy can increase the pathological complete response rate of breast cancer and has the potential for long-term survival benefits. Triple negative breast cancer and hormonal receptor-positive/HER-2-negative breast cancer are the preferred groups for neoadjuvant immunotherapy. Corresponding strategies for drug combinations and subsequent treatment plans are provided. Meanwhile,the expert group confirms that the expression of tumor infiltrating lymphocytes can indicate the efficacy of neoadjuvant immunotherapy. The combination of neoadjuvant immunotherapy and targeted therapy is promising in the treatment of triple negative breast cancer and HER-2 positive breast cancer,but further verification is needed.

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