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中华乳腺病杂志(电子版) ›› 2023, Vol. 17 ›› Issue (03) : 167 -171. doi: 10.3877/cma.j.issn.1674-0807.2023.03.007

综述

抗体药物偶联物在人表皮生长因子受体2低表达晚期乳腺癌中的应用
刘晓蒙, 曹孟儒, 蔡莉()   
  1. 150081 哈尔滨医科大学附属肿瘤医院乳腺内科二病区
  • 收稿日期:2022-04-24 出版日期:2023-06-01
  • 通信作者: 蔡莉

Application of antibody-drug conjugates in advanced breast cancer with low expression of human epidermal growth factor receptor 2

Xiaomeng Liu, Mengru Cao, Li Cai()   

  • Received:2022-04-24 Published:2023-06-01
  • Corresponding author: Li Cai
引用本文:

刘晓蒙, 曹孟儒, 蔡莉. 抗体药物偶联物在人表皮生长因子受体2低表达晚期乳腺癌中的应用[J]. 中华乳腺病杂志(电子版), 2023, 17(03): 167-171.

Xiaomeng Liu, Mengru Cao, Li Cai. Application of antibody-drug conjugates in advanced breast cancer with low expression of human epidermal growth factor receptor 2[J]. Chinese Journal of Breast Disease(Electronic Edition), 2023, 17(03): 167-171.

20世纪80年代以来,针对HER-2靶点的治疗显著改善了乳腺癌患者的生存结局,但仅限于免疫组织化学染色HER-2(3+)或(2+)且ISH阳性的患者。新型抗体药物偶联物(ADC)不只对HER-2阳性,甚至对以往归于HER-2阴性的HER-2低表达乳腺癌也有效。HER-2低表达患者约占乳腺癌患者的45%~55%,然而,HER-2低表达乳腺癌的生物学特征和临床特点尚未阐明,其巨大的治疗需求也暂未被满足。本文主要分析了HER-2低表达的定义,探索了HRE-2低表达乳腺癌这一特殊亚型的生物学特征,整理了新型ADC在HER-2低表达乳腺癌中的研究数据,希望可以提供一种新的诊疗思路和潜在的治疗策略。

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