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中华乳腺病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (06) : 386 -389. doi: 10.3877/cma.j.issn.1674-0807.2020.06.012

所属专题: 文献

综述

终末分化诱导非编码RNA在乳腺癌中的作用及研究进展
陆蝶1, 狄世豪1, 张智弘1,()   
  1. 1. 210029 南京医科大学第一附属医院病理科
  • 收稿日期:2020-02-28 出版日期:2020-12-01
  • 通信作者: 张智弘

Role of terminal differentiation-induced non-coding RNA in breast cancer

Die Lu1, Shihao Di1, Zhihong Zhang1()   

  • Received:2020-02-28 Published:2020-12-01
  • Corresponding author: Zhihong Zhang
引用本文:

陆蝶, 狄世豪, 张智弘. 终末分化诱导非编码RNA在乳腺癌中的作用及研究进展[J]. 中华乳腺病杂志(电子版), 2020, 14(06): 386-389.

Die Lu, Shihao Di, Zhihong Zhang. Role of terminal differentiation-induced non-coding RNA in breast cancer[J]. Chinese Journal of Breast Disease(Electronic Edition), 2020, 14(06): 386-389.

长链非编码RNA广泛参与生物体的病理、生理过程,其中,终末分化诱导非编码RNA(TINCR)可通过多种机制参与上皮细胞分化,在乳腺癌细胞中常异常表达。TINCR可作为癌基因,影响乳腺癌的发生、发展,并有可能成为乳腺癌诊断和预后评估的标志物以及潜在的治疗靶点。笔者针对TINCR在乳腺癌中的作用机制及研究进展进行综述。

图1 lncRNA作为ceRNA调节miRNA影响肿瘤发生、发展示意图
图2 TINCR调控癌细胞周期示意图
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