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中华乳腺病杂志(电子版) ›› 2016, Vol. 10 ›› Issue (06) : 362 -365. doi: 10.3877/cma.j.issn.1674-0807.2016.06.008

综述

HER-2 基因突变在乳腺癌中的研究现状
赵玮1, 边莉1, 江泽飞1,()   
  1. 1.100071 北京,军事医学科学院附属医院乳腺肿瘤内科
  • 收稿日期:2016-03-04 出版日期:2016-12-01
  • 通信作者: 江泽飞
  • 基金资助:
    国家自然科学基金资助项目(81472477)

HER-2 gene mutation in breast cancer research

Wei Zhao, Li Bian, Zefei Jiang()   

  • Received:2016-03-04 Published:2016-12-01
  • Corresponding author: Zefei Jiang
引用本文:

赵玮, 边莉, 江泽飞. HER-2 基因突变在乳腺癌中的研究现状[J/OL]. 中华乳腺病杂志(电子版), 2016, 10(06): 362-365.

Wei Zhao, Li Bian, Zefei Jiang. HER-2 gene mutation in breast cancer research[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2016, 10(06): 362-365.

乳腺癌目前是中国女性发病率第1 位的恶性肿瘤,严重威胁着患者的健康。 HER-2 阳性乳腺癌约占侵袭性乳腺癌的20%~30%,与肿瘤的高侵袭性、高复发风险、进展快速及不良预后相关。大量针对HER-2 靶点药物的研发及临床应用,改变了这部分患者的预后,但抗HER-2 靶向药物的耐药极大限制了该类药物的应用。 随着精准医学测序技术的发展,越来越多的HER-2 基因突变被报道,HER-2 基因的突变现象可能会对疾病的发生、发展及治疗产生影响,可能是抗HER-2 药物耐药的一个重要原因,笔者总结了HER-2 基因突变在乳腺癌中的主要研究成果,包括HER-2 基因的基本结构和功能、HER-2 基因突变检测方法、HER-2 基因突变与靶向药物耐药等。

表1 乳腺癌患者HER-2 突变情况
图1 HER-2 基因突变示意图 注:图中标注的是基因位点
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