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中华乳腺病杂志(电子版) ›› 2016, Vol. 10 ›› Issue (03) : 174 -176. doi: 10.3877/cma.j.issn.1674-0807.2016.03.011

综述

12 基因模型对乳腺导管原位癌预后预测的研究进展
唐静1,2, 王先明1,()   
  1. 1.518000 深圳市第二人民医院甲乳外科
    2.515041 汕头大学医学院
  • 收稿日期:2015-04-14 出版日期:2016-06-01
  • 通信作者: 王先明

Advance in 12-gene model for predicting prognosis of breast ductal carcinoma in situ

Jing Tang, Xianming Wang()   

  • Received:2015-04-14 Published:2016-06-01
  • Corresponding author: Xianming Wang
引用本文:

唐静, 王先明. 12 基因模型对乳腺导管原位癌预后预测的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2016, 10(03): 174-176.

Jing Tang, Xianming Wang. Advance in 12-gene model for predicting prognosis of breast ductal carcinoma in situ[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2016, 10(03): 174-176.

DCIS 作为一种异质性病变,受到越来越多的关注,但传统的以病变细胞形态、结构、分级以及是否坏死存在的分型方法不能准确区分DCIS 的亚型,不能对其治疗方式或预后做出较准确的评估与预测,难以满足精准治疗的要求。 目前国内外的研究致力于在基因组学层面对DCIS 进行深入的认识与分型,并建立完善的DCIS 预后预测的基因模型。 笔者简单介绍了与DCIS 相关的基因检测,如乳腺癌高通量基因检测(Mammaprint)、Oncotype DX 21 基因检测、Prosigna 等,着重分析了DCIS 12 基因模型的建立过程、评分方法、对DCIS 预后的风险评估及其对DCIS 精准治疗的意义, 以期为临床工作提供参考。

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