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中华乳腺病杂志(电子版) ›› 2010, Vol. 04 ›› Issue (05) : 544 -553. doi: 10.3877/cma.j.issn.1674-0807.2010.05.006

乳腺疾病病理学及基础研究专题

P21-activated kinase 1 and breast cancer
Jun-Xiang Zhang1, Da-Qiang Li1, Rakesh Kumar1,()   
  1. 1.Department of Biochemistry and Molecular Biology,The George Washington University Medical Center,Washington,DC 20037,USA
  • 出版日期:2010-10-01
  • 通信作者: Rakesh Kumar
  • Published:2010-10-01
引用本文:

Jun-Xiang Zhang, Da-Qiang Li, Rakesh Kumar. P21-activated kinase 1 and breast cancer[J/OL]. 中华乳腺病杂志(电子版), 2010, 04(05): 544-553.

Figure 1 Summary of the functional roles of PAK1 in breast cancer
[1]
Manser E,Leung T,Salihuddin H,et al.A brain serine/threonine protein kinase activated by Cdc42 and Rac1.Nature,1994,367:40-46.
[2]
Dummler B,Ohshiro K,Kumar R,et al.Pak protein kinases and their role in cancer.Cancer Metastasis Rev,2009,28:51-63.
[3]
Balasenthil S,Sahin AA,Barnes CJ,et al.p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells.J Biol Chem,2004,279:1422-1428.
[4]
Kok M,Zwart W,Holm C,et al.PKA-induced phosphorylation of ERalpha at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer.Breast Cancer Res Treat,2010.DOI:10.1007/s10549-010-0798-y.(2010-05-09)[2010-05-10].http://www.springerlink.com/content/r00841u172h86821/fulltext.pdf.
[5]
Reddy SD,Ohshiro K,Rayala SK,et al.MicroRNA-7,a homeobox D10 target,inhibits p21-activated kinase 1 and regulates its functions.Cancer Res,2008,68:8195-8200.
[6]
Wang RA,Vadlamudi RK,Bagheri Yarmand R,et al.Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands.J Cell Biol,2003,161:583-592.
[7]
Wang RA,Mazumdar A,Vadlamudi RK,et al.P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium.Embo J,2002,21:5437-5447.
[8]
Wang RA,Zhang H,Balasenthil S,et al.PAK1 hyperactivation is sufficient for mammary gland tumor formation.Oncogene,2006,25:2931-2936.
[9]
Mazumdar A,Kumar R.Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells.FEBS Lett,2003,535:6-10.
[10]
Salh B,Marotta A,Wagey R,et al.Dysregulation of phosphatidylinositol 3-kinase and downstream effectors in human breast cancer.Int J Cancer,2002,98:148-154.
[11]
Vadlamudi RK,Bagheri Yarmand R,Yang Z,et al.Dynein light chain 1,a p21-activated kinase 1-interacting substrate,promotes cancerous phenotypes.Cancer Cell,2004,5:575-585.
[12]
Balasenthil S,Barnes CJ,Rayala SK,et al.Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells.FEBS Lett,2004,567:243-247.
[13]
Joyce D,Bouzahzah B,Fu M,et al.Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway.J Biol Chem,1999,274:25 245-25 249.
[14]
Manavathi B,Rayala SK,Kumar R.Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1.J Biol Chem,2007,282:19 820-19 830.
[15]
Adam L,Vadlamudi R,Kondapaka SB,et al.Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase.J Biol Chem,1998,273:28 238-28 246.
[16]
Vadlamudi RK,Adam L,Wang RA,et al.Regulatable expression of p21-activated kinase-1 promotes anchorageindependent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells.J Biol Chem,2000,275:36 238-36 244.
[17]
Yang Z,Rayala S,Nguyen D,et al.Pak1 phosphorylation of snail,a master regulator of epithelial-to-mesenchyme transition,modulates snail's subcellular localization and functions.Cancer Res,2005,65:3179-3184.
[18]
Li Q,Mullins SR,Sloane BF,et al.p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer.Neoplasia,2008,10:314-329.
[19]
Nola S,Sebbagh M,Marchetto S,et al.Scrib regulates PAK activity during the cell migration process.Hum Mol Genet,2008,17:3552-3565.
[20]
Bagheri Yarmand R,Vadlamudi RK,Wang RA,et al.Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis.J Biol Chem,2000,275:39 451-39 457.
[21]
Kiosses WB,Hood J,Yang S,et al.A dominant-negative p65 PAK peptide inhibits angiogenesis.Circ Res,2002,90:697-702.
[22]
Deroanne C,Vouret Craviari V,Wang B,et al.Ephrin A1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway.J Cell Sci,2003,116:1367-1376.
[23]
Hood JD,Frausto R,Kiosses WB,et al.Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis.J Cell Biol,2003,162:933-943.
[24]
Conway RE,Petrovic N,Li Z,et al.Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction.Mol Cell Biol,2006,26:5310-5324.
[25]
Buzdar AU.Endocrine therapy in the treatment of metastatic breast cancer.Semin Oncol,2001,28:291-304.
[26]
Rayala SK,Molli PR,Kumar R.Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity.Cancer Res,2006,66:5985-5988.
[27]
Holm C,Rayala S,Jirström K,et al.Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients.J Natl Cancer Inst,2006,98:671-680.
[28]
Rayala SK,Talukder AH,Balasenthil S,et al.P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation.Cancer Res,2006,66:1694-1701.
[29]
Zwijsen RM,Buckle RS,Hijmans EM,et al.Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.Genes Dev,1998,12:3488-3498.
[30]
Bostner J,Ahnström Waltersson M,Fornander T,et al.Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer.Oncogene,2007,26:6997-7005.
[31]
Bostner J,Skoog L,Fornander T,et al.Estrogen receptor-alpha phosphorylation at serine 305,nuclear p21-activated kinase 1 expression,and response to tamoxifen in postmenopausal breast cancer.Clin Cancer Res,2010,16:1624-1633.
[32]
Akinmade D,Talukder AH,Zhang Y,et al.Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells.Br J Cancer,2008,98:1132-1140.
[33]
Hirokawa Y,Arnold M,Nakajima H,et al.Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance.Cancer Biol Ther,2005,4:956-960.
[34]
He H,Hirokawa Y,Gazit A,et al.The Tyr-kinase inhibitor AG879,that blocks the ETK-PAK1 interaction,suppresses the RAS-induced PAK1 activation and malignant transformation.Cancer Biol Ther,2004,3:96-101.
[35]
Nheu T,He H,Hirokawa Y,et al.PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition.Cell Cycle,2004,3:71-74.
[36]
Hirokawa Y,Levitzki A,Lessene G,et al.Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003,anti-PAK1 drugs(Tyr-kinase inhibitors).Cancer Lett,2007,245:242-251.
[37]
Deacon SW,Beeser A,Fukui JA,et al.An isoform-selective,small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.Chem Biol,2008,15:322-331.
[38]
Viaud J,Peterson JR.An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.Mol Cancer Ther,2009,8:2559-2565.
[39]
Murray BW,Guo C,Piraino J,et al.Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.Proc Natl Acad Sci USA,2010,107:9446-9451.
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